[1]周志鸿 韦燕飞 王 青 韩丝银 彭 岳 咸玉雪 彭金清 原鲜玲.蜂王浆抗糖尿病的研究进展[J].大众科技,2022,24(09):102-106.
　Research Progress in the Treatment of Diabetes with Royal Jelly[J].Popular Science & Technology,2022,24(09):102-106.
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蜂王浆抗糖尿病的研究进展()
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《大众科技》[ISSN:1008-1151/CN:45-1235/N]

卷:
24
期数:
2022年09
页码:
102-106
栏目:
医药与卫生
出版日期:
2022-09-20

文章信息/Info

Title:
Research Progress in the Treatment of Diabetes with Royal Jelly
作者:
周志鸿1 韦燕飞2 王 青3 韩丝银2 彭 岳2 咸玉雪2 彭金清2 原鲜玲3　
（1.广西中医药大学赛恩斯新医药学院，广西 南宁 530222； 2.广西中医药大学基础医学院，广西 南宁 530222； 3.广西中医药大学教学实验实训中心基础医学实验中心，广西 南宁 530222）
关键词:
蜂王浆; 糖尿病; 胰岛素; 血糖
Keywords:
royal jelly diabetes insulin blood sugar
文献标志码:
A
摘要:
糖尿病（Diabetes Mellitus，DM）是一种复杂的代谢紊乱性疾病，临床特征表现为高血糖和多种并发症。糖尿病的发病率高、致残率高、死亡率高。蜂王浆（Royal Jelly，RJ）为一种高营养天然产物，其药理作用丰富，能够减轻胰岛素抵抗、发挥胰岛素样作用、抑制α-葡萄糖苷酶活性、抑制水甘油通道蛋白9（AQP9）表达、并且诱导单磷酸腺苷活化蛋白激酶（AMPK）、降低胰岛β细胞的损伤率，同时修复已被损坏的胰岛β细胞，从而改善糖尿病病人高血糖症，对治疗糖尿病起一定作用。同时，蜂王浆对于糖尿病并发症的治疗方面也有着很大潜能。通过文献检索，文章对蜂王浆治疗糖尿病作用及其机制进行综述，期望为蜂王浆在糖尿病治疗方面的应用提供一定的科学参考。
Abstract:
Diabetes mellitus (DM) is a complex metabolic disorder, characterized by hyperglycemia and a variety of complications. Diabetes has a high incidence rate, high disability and high mortality. Royal jelly (RJ) is a highly nutritious natural product with complex pharmacological effects. It can reduce insulin resistance, play an insulin-like effect, inhibit α-glucosidase activity, inhibit aquaglycerol channel protein 9 (AQP9) expression, and induce monophosphate adenosine activation protein kinase (AMPK), reduce the damage rate of islet β cells, while repairing the damaged islet β cells, thereby improving hyperglycemia in diabetic patients, playing a certain role in the treatment of diabetes. At the same time, royal jelly also has great potential for the treatment of diabetic complications. Through literature search, this paper summarizes the effect and mechanism of royal jelly in the treatment of diabetes, hoping to provide some scientific references for the application of royal jelly in the treatment of diabetes.

参考文献/References:

[1] 顾今，杨开，叶帮伟，等. 食(药)用菌抗糖尿病研究进展[J]. 中国食用菌，2010，29(1): 7-10. [2] 诸夔妞，寿旗扬，田雨闪，等. 绞股蓝治疗糖尿病的效应成分群及作用机制研究进展[J]. 中草药，2020，51(8): 2248-2257. [3] 陶桂香，徐洋. 1型糖尿病发病机制及治疗研究[J]. 中国免疫学杂志，2015，31(10): 1297-1303. [4] 刘亚平，邢素芳. 中西药联合治疗糖尿病[J]. 光明中医，2015，30(3): 629-630. [5] 刘一冰，陈恒，徐浩，等. 蜂王浆对雌性未孕大鼠乳腺组织的影响[J]. 中国实验动物学报，2021，29(2): 160-167. [6] 武凤君，高天舒. 蜂产品对糖尿病患者血糖的影响[J]. 辽宁中医药大学学报，2011，13(3): 150-151. [7] Pasupuleti V R, Sammugam L, Ramesh N, et al. Honey, propolis, and royal jelly: A comprehensive review of their biological actions and health benefits[J]. Oxidative Medicine and Cellular Longevity, 2017, 2017: 1259510. [8] 陈露，吴珍红，缪晓青. 蜂王浆的研究现状[J]. 中国蜂业，2012，63(Z1): 52-54. [9] 陈亚玲，张晶. 蜂王浆的研究进展[J]. 食品研究与开发，2015，36(2): 148-152. [10] Kunugi H, Mohammed Ali A. Royal jelly and its components promote healthy aging and longevity: From animal models to humans[J]. International Journal of Molecular Sciences, 2019, 20(19): 4662. [11] B?an A, Moga M A, Dima L, et al. Royal jelly-a traditional and natural remedy for postmenopausal symptoms and aging-related pathologies[J]. Molecules, 2020, 25(14): 3291. [12] Fratini F, Cilia G, Mancini S, et al. Royal jelly: An ancient remedy with remarkable antibacterial properties[J]. Microbiological Research, 2016, 192: 130-141. [13] Kocot J, Kie?zykowska M, Luchowska-Kocot D, et al. Antioxidant potential of propolis, bee pollen, and royal jelly: Possible medical application[J]. Oxidative Medicine and Cellular Longevity, 2018, 2018: 7074209. [14] 王琦，刘玉玲，王志. 蜂王浆药用价值研究进展[J]. 蜜蜂杂志，2020，40(11): 6-10. [15] Ahmad S, Campos M G, Fratini F, et al. New insights into the biological and pharmaceutical properties of royal jelly[J]. International Journal of Molecular Sciences, 2020, 21(2): 382. [16] Mobasseri M, Ghiyasvand S, Ostadrahimi A, et al. Effect of fresh royal jelly ingestion on glycemic response in patients with type 2 diabetes[J]. Iran Red Crescent Med J, 2015, 17(9): e20074. [17] Khoshpey B, Djazayeri S, Amiri F, et al. Effect of royal jelly intake on serum glucose, apolipoprotein A-I (ApoA-I), apolipoprotein B (ApoB) and ApoB/ApoA-I ratios in patients with type 2 diabetes: A randomized, double-blind clinical trial study[J]. Canadian Journal of Diabetes, 2016, 40(4): 324-328. [18] 史伯伦. 奶粉与蜂王浆冻干粉[J]. 蜜蜂杂志，2009，29(4): 15. [19] 倪辉，吉挺，薛白云. 服用蜂王浆冻干粉结合饮食控制对Ⅱ型糖尿病疗效的观察[J]. 蜜蜂杂志，2003(1): 3-5. [20] 聂绪强，张丹丹，张涵. 炎症、胰岛素抵抗与糖尿病的中药治疗[J]. 中国药学杂志，2017，52(1): 1-7. [21] Kramer K J, Tager H S, Childs C N, et al. Insulin-like hypoglycemic and immunological activities in honeybee royal jelly[J]. Journal of Insect Physiology, 1977, 23(2): 293-295. [22] Salazar-Olivo LA, Paz-González V. Screening of biological activities present in honeybee (Apis mellifera) royal jelly[J]. Toxicol In Vitro, 2005, 19(5): 645-651. [23] Pourmoradian S, Mahdavi R, Mobasseri M, et al. Effects of royal jelly supplementation on glycemic control and oxidative stress factors in type 2 diabetic female: a randomized clinical trial[J]. Chinese Journal of Integrative Medicine, 2014, 20(5): 347-352. [24] Ghanbari E, Nejati V, Khazaei M. Improvement in serum biochemical alterations and oxidative stress of liver and pancreas following use of royal jelly in streptozotocin-induced diabetic rats[J]. Cell Journal, 2016, 18(3): 362-370. [25] Nomura M, Maruo N, Zamami Y, et al. Effect of long-term treatment with royal jelly on insulin resistance in Otsuka Long-Evans Tokushima Fatty (OLETF) rats][J]. Journal of Pharmacological Sciences, 2007, 127(11): 1877-1882. [26] Shidfar F, Jazayeri S, Mousavi S N, et al. Does supplementation with royal jelly improve oxidative stress and insulinresistance in type 2 diabetic patients[J]. Iranian Journal of Public Health, 2015, 44(6): 797-803. [27] Metwally I S E L, Kosba A A. Royal jelly supplementation reduces skeletal muscle lipotoxicity and insulin resistance in aged obese rats[J]. Pathophysiology, 2018, 25(4): 307-315. [28] 汪宁，朱荃，周义维，等. 蜂王浆冻干粉对离体肝脏葡萄糖消耗的影响[J]. 中国老年学杂志，2006(10): 1393-1395. [29] 张燕，李琳琳，木合布力·阿布力孜，等. 新疆昆仑雪菊5种提取物对α-葡萄糖苷酶活性的影响[J]. 中国实验方剂学杂志，2011，17(7): 166-169. [30] 季涛，宿树兰，郭盛，等. 基于α-葡萄糖苷酶抑制活性评价桑叶多组分药效相互作用研究[J]. 中国中药杂志，2016，41(11): 1999-2006. [31] 王远，郑雯，袁田青，等. 辣木叶总黄酮微波辅助提取工艺优化及其抑制α-葡萄糖苷酶活性研究[J]. 核农学报，2018，32(1): 84-94. [32] 朱作艺，张玉，王君虹，等. 蜂王浆蛋白肽的制备及其降血糖和抗氧化活性研究[J]. 食品工业科技，2020，41(17): 45-50，57. [33] 励建荣，齐旦旦，张蕾. 蜂王浆水溶性蛋白质及其水解多肽对自由基的清除能力和对胰脂肪酶和α-葡萄糖苷酶的抑制活性[J]. 中国食品学报，2012，12(9): 8-15. [34] 陈金成，张吟. AMPK与肝脏糖异生研究进展[J]. 中国现代应用药学，2017，34(7): 1062-1067. [35] Watadani R, Kotoh J, Sasaki D, et al. 10-Hydroxy-2-decenoic acid, a natural product, improves hyperglycemia and insulin resistance in obese/diabetic KK-Ay mice, but does not prevent obesity[J]. Journal of Veterinary Medical Science, 2017, 79(9): 1596-1602. [36] Takikawa M, Kumagai A, Hirata H, et al. 10-Hydroxy-2-decenoic acid, a unique medium-chain fatty acid, activates 5-AMP-activated protein kinase in L6 myotubes and mice[J]. Molecular Nutrition and Food Research, 2013, 57(10): 1794-1802. [37] Yoshida M, Hayashi K, Watadani R, et al. Royal jelly improves hyperglycemia in obese/diabetic KK-Ay mice[J]. Journal of Veterinary Medical Science, 2017, 79(2): 299-307. [38] 李原，侯娇娇，任旭霞，等. 水通道蛋白9在2型糖尿病大鼠肝脏中的表达变化[J]. 第三军医大学学报，2018，40(1): 31-36. [39] Hou J, Li Y, Ren X, et al. Similar aquaporin9 and MAPK expression profiles in the liver of types 1 and 2 diabetes mellitus[J]. Hormone and Metabolic Research, 2018, 50(5): 414-421. [40] Kuriyama H, Shimomura I, Kishida K, et al. Coordinated regulation of fat-specific and liver-specific glycerol channels, aquaporin adipose and aquaporin 9[J]. Diabetes, 2002, 51(10): 2915-2921. [41] Rojek A M, Skowronski M T, Füchtbauer E M, et al. Defective glycerol metabolism in aquaporin 9 (AQP9) knockout mice[J]. Proceedings of the National Academy of Sciences of the United States of America, 2007, 104(9): 3609-3614. [42] Usui S, Soda M, Iguchi K, et al. Down-regulation of aquaporin 9 gene transcription by 10-hydroxy-2-decenoic acid: A major fatty acid in royal jelly[J]. Food Science and Nutrition, 2019, 7(11): 3819-3826. [43] 王春亮，齐鹏，陈爱荣. 桑叶多糖治疗糖尿病机制的研究进展[J]. 中国临床药理学杂志，2019，35(1): 91-95. [44] 汪宁，朱荃，周义维，等. 蜂王浆冻干粉对HepG2细胞葡萄糖消耗作用及对糖尿病小鼠降糖作用的实验研究[J]. 食品科学，2006(9): 233-235. [45] 吴珍红，刘文娟，缪晓青，等. 蜂王浆复方降血糖作用的初步研究[J]. 中国蜂业，2006(12): 8-10. [46] 方小玲. 老年2型糖尿病心脑血管并发症与脂质代谢的相关性分析[J]. 湖南师范大学学报(医学版)，2010，7(3): 53-54，57. [47] 潘永明，游蒙蒙，胡福良. 蜂王浆通过增加NO的产生起到降低血压和血管舒张作用[C]. 2019中国蜂业博览会暨全国蜂产品市场信息交流会论文集，2019. [48] 裘项旭，胡美君，叶响荣. 糖尿病并发眼病相关危险因素分析[J]. 实用预防医学，2015，22(2): 211-213. [49] Imada T, Nakamura S, Kitamura N, et al. Oral administration of royal jelly restores tear secretion capacity in rat blink-suppressed dry eye model by modulating lacrimal gland function[J]. PLoS One, 2014, 9(9): e106338. [50] 吴标良，唐乾利，冯烈，等. 烧伤皮肤再生医疗技术治疗糖尿病足部溃疡疗效的系统评价[J]. 中国全科医学，2014，17(32): 3851-3854. [51] Siavash M, Shokri S, Haghighi S, et al. The efficacy of topical Royal Jelly on diabetic foot ulcers healing: A case series[J]. Journal of Research in Medical Sciences, 2011, 16(7): 904-909. [52] 阚默，王继凤，明思彤，等. 蜂王浆药理作用研究进展[J]. 特产研究，2020，59(6): 55-59.

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备注/Memo

备注/Memo:
【收稿日期】2022-06-28 【基金项目】2019广西中医药大学校级课题自然科学面上项目（2019MS002）。 【作者简介】周志鸿（1999－），男，广东高州人，广西中医药大学赛恩斯新医药学院学生，研究方向为中药药效及作用机理。 【通信作者】原鲜玲（1978－），女，广西武宣人，广西中医药大学教学实验实训中心基础医学实验中心高级实验师，研究方向为民族医药防治肝病。
更新日期/Last Update: 2022-10-14