[1]杨小徽 张荣臻 俞 渊 王清坚.中医综合序贯疗法治疗转移性肝癌的 临床应用研究[J].大众科技,2019,21(01):23-25.
　Clinical Application of Comprehensive Sequential Therapy of TCM in the Treatment of Hepatic Metastatic Carcinoma[J].Popular Science & Technology,2019,21(01):23-25.
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中医综合序贯疗法治疗转移性肝癌的 临床应用研究()
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《大众科技》[ISSN:1008-1151/CN:45-1235/N]

卷:
21
期数:
2019年01
页码:
23-25
栏目:
医药与卫生
出版日期:
2019-01-20

文章信息/Info

Title:
Clinical Application of Comprehensive Sequential Therapy of TCM in the Treatment of Hepatic Metastatic Carcinoma
作者:
杨小徽1 张荣臻2 俞 渊2 王清坚2
（1.广西国际壮医医院，广西 南宁 530001；2.广西中医药大学第一附属医院，广西 南宁 530022）
关键词:
转移性肝癌; 中医; 综合序贯疗法; 应用
Keywords:
hepatic metastasis carcinoma (HMC);  TCM;  comprehensive sequential therapy;  application
文献标志码:
A
摘要:
目的：探讨中医综合序贯疗法对转移性肝癌（hepatic metastasis carcinoma，HMC）的临床疗效，为治疗转移性肝癌提供临床依据。方法：将符合纳入标准的80 例患者随机分成治疗组和对照组，各组均为40 例，治疗组为中医综合序贯疗法组，即在全程中医辨证论治的诊疗过程中，根据患者具体病情，序贯给予手术、化疗、消融、生物疗法，疗程6 个月；对照组则为非中医治疗组，根据病情所需，配合手术、化疗、消融、生物治疗，疗程6 个月。观察患者治疗前后的近期疗效、生存率、生活质量等指标。结果：治疗组与对照组患者治疗后血清AFP 水平均明显下降，两组间比较治疗组优于对照组（P＞0.05），差异无统计学意义；两组疾病控制率（DCR）分别为90 %、77.5 %（P＜0.05），差异有统计学意义；生存情况：治疗组和对照组的1 年生存率分别为85 %、70%；1 年后生存质量统计：两组治疗后的生活质量均有所改善，两组的生活质量变化提高率：41.2%、35.7%，稳定率：52.9 %、50%（P＜0.05），差异有统计学意义，表明治疗组患者的生活质量得到明显改善。结论：应用中医综合序贯疗法治疗转移性肝癌，可改善患者症状及生活质量，同时还能协同增效，提高疾病控制率，保护肝功能，延长患者生存期限，不失为治疗转移性肝癌的有效方法之一。
Abstract:
Objective: To explore the clinical effect of comprehensive sequential therapy of traditional Chinese medicine (TCM) on hepatic metastasis carcinoma (HMC), and to provide clinical basis for the treatment of metastatic HMC. Methods: 80 patients who met the inclusion criteria were randomly divided into the treatment group and the control group, 40 cases in each group. The treatment group was the comprehensive sequential therapy group of TCM, that is, in the whole process of diagnosis and treatment was based on syndrome differentiation of TCM, and according to the specific conditions of patients, combined with sequential surgery, chemotherapy, ablation and biotherapy, the course of the treatment was 6 months. The control group is a non-TCM treatment group, only according to the need of the disease, combined with surgery, chemotherapy, ablation and biotherapy, the course was 6 months. The short-term curative effect, survival rate and quality of life were observed before and after treatment. Results: the serum AFP levels in the treatment group and the control group were significantly lower than those in the control group (P＞0.05), and there was no significant difference between the treatment group and the control group (P＞0.05). The disease control rates of the two groups were 90% and 77.5%, respectively (P＜0.05), the survival rate was 85% in the treatment group and 70% in the control group. Quality of life statistics after one year: the life quality in the both groups was improved after treatment, the improvement rate of life quality of the two groups were 41.2%, 35.7%, respectively, the stability rate of them were 52.9% and 50%, respectively. The difference was statistically significant (P＜0.05), which indicated that the quality of life of the patients in the treatment group was improved obviously. Conclusion: The application of in the treatment of metastatic HMC can improve the symptoms and life quality of the patients, and improve the disease control rate with synergies, protect the liver function and prolong the life span of the patients. Therefore, the comprehensive sequential therapy is one of the effective methods for the treatment of metastatic HMC .

参考文献/References:

【参考文献】 [1] 谭刚,朱晓锋.健脾补肝消癥法联合卡培他滨治疗转移性肝癌的临床观察[J].实用中西医结合临床,2013,13(7):41-42. [2] 王凤山,刘永锋.转移性肝癌的治疗[J].世界华人消化杂志, 2008,16(2):115-119. [3] 袁航,任统伟,杨银成.转移性肝癌综合介入治疗效果观察[J].航空航天医学杂志,2017,28(6):705-707. [4] 陈军可.中医药防治肿瘤转移的思路与方法[J].陕西中医, 2005,26(12):1341-1342. [5] 刘寨东,齐元富,李秀荣.转移性肝癌的中西医治疗现状[J].山东中医药大学学报,2011,35(4):382-384. [6] 姜海英,张燕妮,许娟,等.注射用薏苡仁提取物联合 TACE术治疗转移性肝癌的临床疗效分析[J].现代肿瘤医学,2012, 20(8):1662-1665. [7] Lu Y,Li C S,Dong Q.Chinese herb related molecules of cancer-cell-apoptosis:a minireview of progress between Kanglaite injection and related genes[J].Journal of Experimental & Clinical Cancer Research,2008,27(1):31. [8] 唐由君,刘寨东,许云.田柴合剂治疗22 例转移性肝癌的临床研究[J].中国中西医结合影像学杂志,2004,2(2):122-123. [9] 欧阳华强,黄雯霞,刘鲁明,等.消瘕方联合介入治疗乳腺癌肝转移 42 例疗效观察[J].新中医,2006,38(11):46-47.

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备注/Memo

备注/Memo:
【收稿日期】2018-11-09 【基金项目】2005 年广西壮族自治区卫生与计划生育委员会自筹课题（z2005074）。 【作者简介】杨小徽，广西国际壮医医院脾胃肝病科住院医师，研究方向为肝脏疾病的中医药防治。 【通信作者】王清坚（1972－），男，广西中医药大学第一附属医院主任医师，研究方向为肝脏疾病的临床治疗。
更新日期/Last Update: 2019-02-21