[1]卢岳虹 潘 玲 谭玉萍 冯 原 陆彩云 冯玉清 苏齐鉴 罗珍贞.支气管肺泡灌洗液(1,3)-β-D-葡聚糖检测 对慢性呼吸系统疾病合并真菌感染诊断的 临床价值[J].大众科技,2019,21(02):73-75,81.
 Diagnostic Value of (1, 3)-β-D-Glucan of Bronchoalveolar Lavage Fluid in Chronic Respiratory Diseases with Fungal Infection[J].Popular Science & Technology,2019,21(02):73-75,81.
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支气管肺泡灌洗液(1,3)-β-D-葡聚糖检测 对慢性呼吸系统疾病合并真菌感染诊断的 临床价值()
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《大众科技》[ISSN:1008-1151/CN:45-1235/N]

卷:
21
期数:
2019年02
页码:
73-75,81
栏目:
医药与卫生
出版日期:
2019-02-20

文章信息/Info

Title:
Diagnostic Value of (1, 3)-β-D-Glucan of Bronchoalveolar Lavage Fluid in Chronic Respiratory Diseases with Fungal Infection
作者:
卢岳虹1 潘 玲2 谭玉萍2 冯 原2 陆彩云2 冯玉清2 苏齐鉴2 罗珍贞2
(1. 广西中医药大学,广西 南宁 530001;2.广西中医药大学附属瑞康医院,广西 南宁 530011)
关键词:
支气管肺泡灌洗液(13)-β-D-葡聚糖真菌感染早期诊断
Keywords:
Bronchoalveolar lavage fluid (1 3)-β-D-glucan fungal infection early diagnosis
文献标志码:
A
摘要:
目的:探讨支气管肺泡灌洗液(1, 3) -β-D-葡聚糖(BG)检测对慢性呼吸系统疾病合并真菌感染的诊断价值。方法:选取2013 年5 月至2016 年12 月在广西中医药大学附属瑞康医院呼吸科与重症医学科二区住院的90 例慢性呼吸系统疾病患者作为研究对象,根据具体病情,这些患者被分为真菌感染组、普通感染组、非感染组,每组30 例,分别采集患者的血浆和肺泡灌洗液标本进行葡聚糖检测试验,比较三组患者血浆和肺泡灌洗液BG 浓度及对真菌感染预测效果。结果:三组患者血浆及肺泡灌洗液BG 浓度比较,真菌感染组>普通感染组>无感染组,差异有统计学意义(P<0.05)。血浆G 试验浓度为66.07pg/mL时的约登指数值最大为0.584,敏感性为66.7%,特异性为91.7%;肺泡灌洗液G 试验浓度为78.3pg/mL 时的约登指数值最大为0.733,敏感性为80%,特异性为93.3%。结论:肺泡灌洗液G 试验较血浆G 试验对早期真菌感染的诊断更有临床价值,值得临床推广应用。
Abstract:
Objective: To explore the diagnostic value of detecting (1, 3) -β-D-glucan of bronchoalveolar lavage for chronic respiratory disease with fungal infection. Methods: From May 2013 to December 2016, 90 cases of patients with chronic respiratory diseases admitted to the department of respiratory and critical care medicine, Ruikang Hospital Affiliated to Guangxi University of Chinese Medicine were selected as research objects. According to the specific conditions, these patients were divided into fungal infection group, general infection group and non-infection group, with 30 cases in each group. The plasma and alveolar lavage fluid samples of the patients were collected for BG detection, and the concentration of BG in the plasma and alveolar lavage fluid and the predictive effect on fungal infection in the three groups were compared. Results: The BG concentration of the plasma and alveolar lavage of the three groups, fungi group > general infection group > non-infection group, the difference was statistically significant (P<0.05). When the BG concentration of plasma was 66.07pg/mL, the maximum value of Jordan index was 0.584 and sensitivity was 66.7%, specificity was 91.7%; when the BG concentration of alveolar lavage fluid was78.3pg/mL, the maximum value of Jordan index was 78.3pg/mL and sensitivity was 80%, specificity was 93.3%. Conclusion: Compared with the plasma G test, the alveolar lavage G test has more clinical value in the diagnosis of early fungal infection, which is worthy of clinical application.

参考文献/References:

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备注/Memo

备注/Memo:
【收稿日期】2018-12-05 【基金项目】广西卫生厅课题(Z2013226)。 【作者简介】卢岳虹(1994-),广西中医药大学在读研究生,研究方向为中西结合防治呼吸系统疾病。 【通信作者】潘玲(1997-),广西中医药大学附属瑞康医院副主任医师,研究方向为中西结合防治呼吸系统疾病。
更新日期/Last Update: 2019-04-19