[1]郭德炜 韦熔煌 陈泉亨 刘春强.基于JAK/STAT信号通路探讨中医药在溃疡性结肠炎中的应用[J].大众科技,2023,25(10):81-85.
 Discussion on the Application of Traditional Chinese Medicine in Ulcerative Colitis Based on JAK/STAT Signaling Pathway[J].Popular Science & Technology,2023,25(10):81-85.
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基于JAK/STAT信号通路探讨中医药在溃疡性结肠炎中的应用()
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《大众科技》[ISSN:1008-1151/CN:45-1235/N]

卷:
25
期数:
2023年10
页码:
81-85
栏目:
医药与卫生
出版日期:
2023-10-20

文章信息/Info

Title:
Discussion on the Application of Traditional Chinese Medicine in Ulcerative Colitis Based on JAK/STAT Signaling Pathway
作者:
郭德炜1 韦熔煌1 陈泉亨1 刘春强2 
(1.广西中医药大学,广西 南宁 530001;2.来宾市人民医院,广西 来宾 546199)
关键词:
JAK/STAT信号通路中医药溃疡性结肠炎
Keywords:
JAK/STAT signaling pathway traditional Chinese medicine ulcerative colitis
文献标志码:
A
摘要:
溃疡性结肠炎(UC)是以结肠粘膜慢性炎症为主要特征的肠道疾病,病程长、反复发作、难以治愈,且具有癌变风险。UC的发病机制主要与遗传易感性、上皮屏障缺陷、免疫反应失调和环境因素等密切相关。JAK/STAT信号通路作为大众熟知的炎症通路,可通过细胞信号的传导调节免疫、减轻粘膜屏障损伤、调控炎症参与UC的发病。中医药在UC的治疗中具有个体化、多靶点、疗效持久、低复发率等优势。研究表明中医药可通过对JAK/STAT信号通路进行干预,发挥其抗炎、抗细胞凋亡、减轻肠黏膜损伤的作用而达到治疗目的。因此,文章基于JAK/STAT信号通路探讨中医药在UC中的应用,以期为UC的防治及药物研究提供参考。
Abstract:
Ulcerative colitis (UC) is an intestinal disease mainly characterized by chronic inflammation of the colonic mucosa, with a long, recurrent, intractable course and a high risk of carcinogenesis. The pathogenesis of UC is mainly associated with genetic predisposition, epithelial barrier defects, dysregulated immune responses, and environmental factors. As a well-known inflammatory pathway, the JAK/STAT signaling pathway can regulate immunity, alleviate mucosal barrier damage, and reduce inflammation to participate in the pathogenesis of UC through the transmission of cellular signals. Traditional Chinese medicine (TCM) has many advantages in the treatment of UC, such as individualization, multi-target, long-lasting efficacy, and low recurrence rate. Studies have shown that traditional Chinese medicine (TCM) can achieve therapeutic purposes by intervening on the JAK/STAT signaling pathway to exert its effects of anti-inflammation, anti-apoptosis, and alleviating intestinal mucosal injury. Therefore, this article explores the use of traditional Chinese medicine (TCM) in UC based on the JAK/STAT signaling pathway, with a view to providing a reference for the prevention and treatment of UC and drug research.

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备注/Memo

备注/Memo:
【收稿日期】2023-04-18【作者简介】郭德炜(1992-),男,广东梅州人,广西中医药大学在读硕士研究生,研究方向为肛肠疾病的中医治疗研究。【通信作者】刘春强(1976-),男,黑龙江依安人,来宾市人民医院主任医师,硕士研究生导师,博士,研究方向为肛肠疾病的中医治疗研究。
更新日期/Last Update: 2023-11-01