[1]沙文虎 温小红.桂枝芍药知母汤联合西药对类风湿性关节炎患者血清炎症因子及肢体功能的影响[J].大众科技,2023,25(5):80-83.
　Effect of Guizhi Shaoyao Zhimu Decoction Combined with Western Medicine on Serum Inflammatory Factors and Limb Function in Patients with Rheumatoid Arthritis[J].Popular Science & Technology,2023,25(5):80-83.
点击复制

桂枝芍药知母汤联合西药对类风湿性关节炎患者血清炎症因子及肢体功能的影响()
分享到：

《大众科技》[ISSN:1008-1151/CN:45-1235/N]

卷:
25
期数:
2023年5
页码:
80-83
栏目:
医药与卫生
出版日期:
2023-05-20

文章信息/Info

Title:
Effect of Guizhi Shaoyao Zhimu Decoction Combined with Western Medicine on Serum Inflammatory Factors and Limb Function in Patients with Rheumatoid Arthritis
作者:
沙文虎 温小红
（康乐县人民医院，甘肃 临夏回族自治州 731500）
关键词:
桂枝芍药知母汤; 西药; 类风湿性关节炎; 血清炎症因子; 肢体功能
Keywords:
Guizhi Shaoyao Zhimu decoction;  western medicine;  rheumatoid arthritis;  serum inflammatory factor;  limb function
文献标志码:
A
摘要:
目的：探讨桂枝芍药知母汤联合西药对类风湿性关节炎患者血清炎症因子及肢体功能的影响。方法：以自2021年6月至2022年6月于康乐县人民医院诊治的50例类风湿性关节炎患者为研究对象，采用随机数字表法分为对照组和研究组，各25例，对照组给予西药治疗，研究组在对照组治疗基础上给予桂枝芍药知母汤治疗。对比治疗前后两组中医证候积分、炎症因子、类风湿因子（RF）、红细胞沉降率（ESR）及肢体功能，统计两组临床疗效。结果：治疗前，两组关节肿胀疼痛，痛处固定，屈伸受限，遇寒加重，晨僵屈伸不利，肌肉麻木酸痛，IL-1β、TNF-α、IL-17、RF、ESR、上肢FMAS评分、下肢FMAS评分比较（P＞0.05）；治疗后，两组关节肿胀疼痛，痛处固定，屈伸受限，遇寒加重，晨僵屈伸不利，肌肉麻木酸痛，IL-1β、TNF-α、IL-17、RF、ESR、上肢FMAS评分、下肢FMAS评分均较治疗前改善，与对照组相比，研究组关节肿胀疼痛，痛处固定，屈伸受限，遇寒加重，晨僵屈伸不利，肌肉麻木酸痛，IL-1β、TNF-α、IL-17、RF、ESR、上肢FMAS评分、下肢FMAS评分改善更明显，疗效优于对照组（P＜0.05）。结论：桂枝芍药知母汤联合西药可有效降低类风湿性关节炎患者血清炎症因子，恢复肢体功能，疗效显著，促使患者康复，值得临床推广应用。
Abstract:
Objective: This study aims to explore the effect of Guizhi Shaoyao Zhimu decoction combined with western medicine on serum inflammatory factors and limb function in patients with rheumatoid arthritis. Methods: A total of 50 patients with rheumatoid arthritis who were diagnosed and treated at Kangle County People’s Hospital from June 2021 to June 2022 were selected as the research objects. They were divided into control group and study group by random number table method, with 25 cases each. The control group was treated with western medicine, while the study group was treated with Guizhi Shaoyao Zhimu decoction on the basis of the control group. The TCM syndrome score, inflammatory factors, rheumatoid factor (RF), erythrocyte sedimentation rate (ESR) and limb function of the two groups were compared before and after treatment, and the clinical efficacy of the two groups was counted. Results: Before treatment, the joint swelling and pain, pain fixation, flexion and extension limitation, cold exacerbation, morning stiffness and extension disadvantage, muscle numbness and pain, IL-1β, TNF-α, IL-17, RF, ESR, FMAS score of upper limb and FMAS score of lower limb were compared between the two groups (P>0.05). After treatment, joint swelling and pain, fixed pain, limited flexion and extension, aggravated by cold, morning stiffness and adverse flexion and extension, muscle numbness and pain, IL-1β, TNF-α, IL-17, RF, ESR, FMAS score of upper limb and FMAS score of lower limb were improved in the two groups. Compared with the control group, , the study group had joint swelling and pain, fixed pain points, limited flexion and extension, aggravated by cold, morning stiffness, poor flexion and extension, muscle numbness and soreness, IL-1β、TNF-α、IL-17, RF, ESR, upper limb FMAS score, and lower limb FMAS score was more significant, and the efficacy was better than that of the control group (P<0.05). Conclusion: Guizhi Shaoyao Zhimu decoction combined with western medicine can effectively reduce serum inflammatory factors in patients with rheumatoid arthritis, restore limb function,the effect is significant, and promote the rehabilitation of patients, which is worthy of clinical application.

参考文献/References:

[1]　GIANNINI D, ANTONUCCI M, PETRELLI F, et al. One yearin review 2020: Pathogenesis of rheumatoid arthritis[J]. Clinical and Experimental Rheumatology, 2020, 38(3): 387-397.[2]　LIN Y J, ANZAGHE M, SCHULKE S. Update on the pathomechanism, diagnosis, and treatment options for rheumatoid arthritis[J]. Cells, 2020, 9(4): 880.[3]　张志娇，肖勇洪，朱爽，等. 桂枝芍药知母汤治疗类风湿关节炎研究进展[J]. 国际中医中药杂志，2022，44(6): 704-707.[4]　曹春浩，曾丽，荣晓凤. 大黄素治疗类风湿关节炎的作用机制：基于网络药理学方法[J]. 南方医科大学学报，2022，42(6): 913-921.[5]　中华医学会风湿病学分会. 2018中国类风湿关节炎诊疗指南[J]. 中华内科杂志，2018，57(4): 242-251.[6]　国家食品药品监督管理局. 中药新药临床研究指导原则: 试行[S]. 北京: 中国中医药科技出版社，2002.[7]　陈瑞全，吴建贤，沈显山. 中文版Fugl-Meyer运动功能评定量表的最小临床意义变化值的研究[J]. 安徽医科大学学报，2015(4): 519-521，522.[8]　杨斯翔. 子午流注理论应用于类风湿性关节炎治疗研究进展[J]. 实用中医药杂志，2022，38(6): 1064-1067.[9]　乔利锋，袁普卫，陈松，等. 桂枝芍药知母汤在骨伤科的临床应用进展[J]. 现代中西医结合杂志，2021，30(16): 1814-1818.[10] 徐佳新，许浚，曹勇，等. 中药白芍现代研究进展及其质量标志物的预测分析[J]. 中国中药杂志，2021，46(21): 5486-5495.[11] 向璐，张巧艳，赵琦明，等. 黄芪-当归化学成分、药理作用及临床应用的研究进展[J]. 中草药，2022，53(7): 2196-2213.[12] 王浩，郭凌阁，尚兴朴，等. 基于防风外观性状和内在指标性成分划分防风药材商品规格等级研究[J]. 中草药，2020，51(20): 5320-5327.[13] 王雨来，汪洋，纪保超，等. 血清炎症指标及关节液分析在类风湿关节炎假体周围感染诊断中的应用[J]. 中华骨科杂志，2021，41(14): 957-965.[14] 赵芳，宋秀娟，蔺耐荣，等. 通痹定痛汤热敷治疗类风湿性关节炎疗效观察[J]. 山西中医，2022，38(6): 56-57.[15] 徐佳新，许浚，曹勇，等. 中药白芍现代研究进展及其质量标志物的预测分析[J]. 中国中药杂志，2021，46(21): 5486-5495.[16] 王丹，吴喜民，张东东，等. 中药桂枝化学成分研究[J].中国中药杂志，2020，45(1): 124-132.

相似文献/References:

[1]许冰燕.慢性胃炎的西药治疗临床研究现状及进展[J].大众科技,2021,23(4):82.
　Clinical Research Status and Progress of Western Medicine Treatment of Chronic Gastritis[J].Popular Science & Technology,2021,23(5):82.

备注/Memo

备注/Memo:
【收稿日期】2022-09-22【作者简介】沙文虎（1983－），男，甘肃康乐人，康乐县人民医院主治医师，研究方向为中西医结合治疗类风湿性关节炎。【通信作者】温小红（1974－），女，甘肃康乐人，康乐县人民医院中医主治医师，从事中医方面的研究工作。
更新日期/Last Update: 2023-07-17