[1]岑思婷.兔耳痤疮动物模型研究进展[J].大众科技,2023,25(4):61-65.
　Research Progress in Animal Models of Rabbit Ear Acne[J].Popular Science & Technology,2023,25(4):61-65.
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兔耳痤疮动物模型研究进展()
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《大众科技》[ISSN:1008-1151/CN:45-1235/N]

卷:
25
期数:
2023年4
页码:
61-65
栏目:
轻工与化工
出版日期:
2023-04-20

文章信息/Info

Title:
Research Progress in Animal Models of Rabbit Ear Acne
作者:
岑思婷
（广西中医药大学研究生院，广西 南宁 530200）
关键词:
痤疮; 兔耳; 动物模型
Keywords:
acne;  rabbit ear;  animal model
文献标志码:
A
摘要:
在全球范围内，痤疮总体患病率非常高，而且涵盖各个年龄段，好发于面部，严重影响外在美观，主要与毛囊皮脂增加、雄激素分泌过多、毛囊漏斗部的异常角化、细菌增殖和继发的炎症反应有关，研究发现遗传因素和免疫机制也影响着痤疮的发生发展。中医中药治疗痤疮方法多样，效果明显，鲜有不良反应发生。选择合适的痤疮模型对阐明中医中药治疗痤疮的优势与特色具有重要意义。兔耳痤疮动物模型具有操作简单、可靠性高、重复性好等特点，成为最常用的动物痤疮模型。依据造模的原理将兔耳痤疮模型归纳为微生物感染、化学物质刺激、雄激素以及基因影响等。文章旨在通过对近几年国内外的家兔痤疮模型的建模方法以及对应的模型评价指标进行简要归纳，有利于探究痤疮病因病机、抗痤中药等相关研究中选择适合的兔耳痤疮模型，同时也为构建更加规范化的痤疮动物模型提供参考。
Abstract:
Globally, the overall prevalence of acne is very high, and covers all age groups. It tends to occur on the face, seriously affecting the appearance of the skin. It is mainly related to increased sebum in the hair follicles, excessive androgen secretion, abnormal keratinization of the infundibulum of the hair follicles, bacterial proliferation, and secondary inflammatory reactions. Research has found that genetic factors and immune mechanisms also affect the occurrence and development of acne. There are various methods for treating acne with traditional Chinese medicine, with obvious effects and few adverse reactions. Choosing an appropriate acne model is of great significance in clarifying the advantages and characteristics of traditional Chinese medicine in treating acne. The rabbit ear acne animal model has become the most commonly used animal acne model due to its simple operation, high reliability, and good repeatability. According to the principle of modeling, the rabbit ear acne model was summarized as microbial infection, chemical stimulation, androgen, and gene effects. The purpose of this article is to briefly summarize the modeling methods and corresponding model evaluation indicators of rabbit acne models both at home and abroad in recent years, which is conducive to exploring the etiology and pathogenesis of acne, selecting suitable rabbit ear acne models in related research such as anti acne traditional Chinese medicine, and providing reference for constructing more standardized animal models of acne.

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备注/Memo

备注/Memo:
【收稿日期】2022-09-28【作者简介】岑思婷，广西中医药大学研究生院在读硕士研究生，从事内分泌疾病防治研究。
更新日期/Last Update: 2023-06-16