[1]王梓塨 邱 华 朱玟霜 李 旺 蒙荫杰 王倩倩.细胞外囊泡在肝纤维化进展中的作用机制及临床意义[J].大众科技,2022,24(12):61-65.
　Mechanism and Clinical Significance of Extracellular Vesicles in the Progression of Hepatic Fibrosis[J].Popular Science & Technology,2022,24(12):61-65.
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细胞外囊泡在肝纤维化进展中的作用机制及 临床意义()
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《大众科技》[ISSN:1008-1151/CN:45-1235/N]

卷:
24
期数:
2022年12
页码:
61-65
栏目:
医药与卫生
出版日期:
2022-12-20

文章信息/Info

Title:
Mechanism and Clinical Significance of Extracellular Vesicles in the Progression of Hepatic Fibrosis
作者:
王梓塨1 邱 华2 朱玟霜1 李 旺1 蒙荫杰1 王倩倩1　
（1.广西中医药大学，广西 南宁 530001； 2.广西医科大学附属肿瘤医院，广西 南宁 530021）
关键词:
细胞外囊泡; 外泌体; 肝纤维化; 肝星状细胞; 生物标志物
Keywords:
extracellular vesicles exosomes hepatic fibrosis hepatic stellate cells biomarkers
文献标志码:
A
摘要:
细胞外囊泡是多种细胞释放的双层膜结构的囊泡统称，囊括了外泌体、微囊泡、凋亡小体及肿瘤小泡，介导着细胞间物质交换及信号交流。肝纤维化是各种慢性肝病向肝硬化发展过程中的关键步骤和影响慢性肝病预后的重要环节，其中以肝星状细胞的活化为该环节的核心。文章具体综述了细胞外囊泡在不同层面参与肝纤维化的调控，主要是能通过传递核酸、蛋白质等参与调控肝星状细胞活化与迁移。
Abstract:
Extracellular vesicle is a general term for vesicles with double membrane structure released by various cells, including exosomes, microbubbles, apoptotic bodies and tumor vesicles, which mediate the material exchange and signal exchange between cells. Hepatic fibrosis is a key step in the development of various chronic liver diseases to cirrhosis and an important link affecting the prognosis of chronic liver diseases. The activation of hepatic stellate cells is the core of this link. More and more studies have shown that extracellular vesicles are involved in the regulation of liver fibrosis at different levels, mainly through the transfer of nucleic acids, proteins, etc. to participate in the regulation of hepatic stellate cell activation and migration.

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　Research Progress in the Regulation of Liver Fibrosis by Exosomes[J].Popular Science & Technology,2022,24(12):68.

备注/Memo

备注/Memo:
【收稿日期】2022-05-25 【基金项目】国家自然科学基金项目（No.81860889）；广西自然科学基金资助项目（2020GXNSFAA297113）。 【作者简介】王梓塨（1996－），男，广西中医药大学在读硕士研究生，研究方向为中医药（壮医药）防治慢性肝病的基础与临床研究。
更新日期/Last Update: 2023-03-21