[1]郑博文 郑 洋 郭新华 梁馨云 吴日舟 任秋怡 赵铁建.外泌体调控肝纤维化的研究进展[J].大众科技,2022,24(11):68-71.
　Research Progress in the Regulation of Liver Fibrosis by Exosomes[J].Popular Science & Technology,2022,24(11):68-71.
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外泌体调控肝纤维化的研究进展()
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《大众科技》[ISSN:1008-1151/CN:45-1235/N]

卷:
24
期数:
2022年11
页码:
68-71
栏目:
医药与卫生
出版日期:
2022-11-20

文章信息/Info

Title:
Research Progress in the Regulation of Liver Fibrosis by Exosomes
作者:
郑博文1 郑 洋2 郭新华1 梁馨云1 吴日舟1 任秋怡1 赵铁建1　
（1.广西中医药大学基础医学院，广西 南宁 5430000； 2.广西中医药大学赛恩斯新医药学院，广西 南宁 530222）
关键词:
外泌体; 肝纤维化; miRNA
Keywords:
exosomes liver fibrosis miRNA
文献标志码:
A
摘要:
外泌体是一种微小的细胞外膜囊泡，含有RNA、蛋白质、microRNA和DNA的片段。近年来研究表明外泌体具有功能活性并可进行细胞间信息的传递，且其在调控肝纤维化进程中的作用引起了广泛关注。且已有研究证明通过高表达脂肪间充质干细胞得到的外泌体可以有效缓解肝脏纤维化进程。文章对外泌体在肝纤维化调控中的作用进行综述，以期为肝纤维化的后续临床诊断和治疗提供一个新的方向。
Abstract:
Exosomes are tiny extracellular membrane vesicles that contain fragments of RNA, proteins, micrornas and DNA. In recent years, studies have shown that exosomes have functional activity and can transmit information between cells, and their role in regulating the process of liver fibrosis has attracted extensive attention. In addition, previous studies have shown that exosomes obtained by high expression of adipose-derived mesenchymal stem cells can effectively alleviate the process of liver fibrosis. This article reviews the role of exosomes in the regulation of liver fibrosis, in order to provide a new direction for the subsequent clinical diagnosis and treatment of liver fibrosis.

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备注/Memo

备注/Memo:
【收稿日期】2022-08-12 【基金项目】国家自然科学基金项目（81960751、81960761、81660705）；广西中青年教师科研基础能力提升项目（2020KY59009）；广西壮瑶药重点实验室（GXZYZZ2020-07）；广西自然科学基金青年项目（2020GXNSFBA297094）；广西中医药大学青年项目（2020QN006）。 【作者简介】郑博文（2002－），广西中医药大学基础医学院学生，研究方向为民族药防治慢性肝病。 【通信作者】赵铁建（1957－），广西中医药大学基础医学院教授，硕士，研究方向为民族药防治慢性肝病。
更新日期/Last Update: 2023-03-09