[1]邓 欢 邓司竹 陈 秋.晚期糖基化终产物受体与肥胖的关系[J].大众科技,2022,24(09):93-97.
 Relationship between Advanced Glycation End Products Receptor and Obesity[J].Popular Science & Technology,2022,24(09):93-97.
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晚期糖基化终产物受体与肥胖的关系()
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《大众科技》[ISSN:1008-1151/CN:45-1235/N]

卷:
24
期数:
2022年09
页码:
93-97
栏目:
医药与卫生
出版日期:
2022-09-20

文章信息/Info

Title:
Relationship between Advanced Glycation End Products Receptor and Obesity
作者:
邓 欢1 邓司竹1 陈 秋2 
(1.成都中医药大学,四川 成都 610072; 2.成都中医药大学附属医院,四川 成都 610075)
关键词:
肥胖晚期糖基化终末产物氧化应激荟萃分析
Keywords:
obesity advanced glycation end products oxidative stress meta-analysis
文献标志码:
A
摘要:
目的:论述肥胖的发生发展与糖基化终末产物产生的氧化应激途径密切相关;通过荟萃分析评估肥胖与AGES-RAGE反应轴的相关性。方法:通过检索各大数据库,共搜索到1424篇文章,最终9篇符合纳入标准,使用RevMan软件进行荟萃分析。结果:肥胖患者的血清糖基化终末产物受体低于正常体重人群(MD[95%CI]=-247.65[-319.63,-175.67],Z=6.74,P<0.00001)。结论:肥胖患者的糖基化终末产物受体低于正常体重人群,肥胖与血清糖基化终末产物受体呈负相关。
Abstract:
Objective: To discuss that the occurrence and development of obesity is closely related to the oxidative stress pathway of advanced glycation end products. The correlation between obesity and ages-rage response axis was evaluated by Meta-analysis. Methods: A total of 1424 articles were searched by searching the major databases, and finally 9 articles met the inclusion criteria. A meta-analysis was conducted using Revman software. Results: the serum receptor for advanced glycation end products in obese patients was lower than that in normal weight people (MD [95% CI] = -247.65 [-319.63, -175.67], z =6.74, P < 0.00001). Conclusion: The receptor of advanced glycation end products in obese patients is lower than that in normal weight people, and obesity is negatively correlated with serum receptor of advanced glycation end products.

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备注/Memo

备注/Memo:
【收稿日期】2022-06-20 【基金项目】国家重大疑难疾病中西医临床协作项目(CYW2019079)。 【作者简介】邓欢(1996-),女,成都中医药大学在读硕士研究生,研究方向为内分泌。
更新日期/Last Update: 2022-10-14