[1]罗琨炽 李钊文 谭婷心 刘玉清.动态加压速热灭菌对中药粉及最终成品有效成分影响[J].大众科技,2022,24(05):45-48.
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动态加压速热灭菌对中药粉及最终成品 有效成分影响()
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《大众科技》[ISSN:1008-1151/CN:45-1235/N]

卷:
24
期数:
2022年05
页码:
45-48
栏目:
出版日期:
2022-05-20

文章信息/Info

Title:
Effect of Dynamic Pressure Rapid Thermal Sterilization on Effective Components of Traditional Chinese Medicine Powder and Final Product
作者:
罗琨炽 李钊文 谭婷心 刘玉清
（广西梧州制药（集团）股份有限公司，广西 梧州 543000）
关键词:
动态加压; 速热灭菌; 中药粉; 有效成分
Keywords:
dynamic pressure rapid thermal sterilization traditional chinese medicine powder active ingredient
文献标志码:
A
摘要:
目的：试验确定动态加压速热灭菌对中药粉及最终产品的最优工艺条件并对其有效成分进行对比。方法：对3种常见灭菌方式进行对比，将有效成分、微生物限度值为指标，评价优化的动态加压速热灭菌工艺，以及湿热灭菌法及干热灭菌法对当归、黄芪、三七三种中药粉灭菌前后品质的影响。结果：动态加压速热灭菌工艺条件为170℃、灭菌时间为6 s，灭菌率达100%。3种不同灭菌方式的微生物限度值对比为，动态加压速热灭菌法＞湿热灭菌法＞干热灭菌法；结论：动态加压速热灭菌工艺能保证黄芪、三七等原生粉微生物限度符合要求，并且效果较常规灭菌方法优，有望替代中药粉的常规灭菌技术。
Abstract:
Objective: To determine the optimal process conditions of dynamic pressure rapid thermal sterilization for traditional Chinese medicine powder and final products, and compare its effective components. Methods: Three common sterilization methods were compared, and the effective components and microbial limit values were used as indicators to evaluate the optimized dynamic pressure rapid heat sterilization process, as well as the effects of damp heat sterilization and dry heat sterilization on the quality of Angelica sinensis, Astragalus membranaceus and Panax notoginseng before and after sterilization. Results: The process condition of dynamic pressure rapid heat sterilization was 170 ℃, the sterilization time was 6 s, and the sterilization rate was 100%. The microbial limit values of three different sterilization methods were compared as follows: dynamic pressure rapid heat sterilization > damp heat sterilization > dry heat sterilization. Conclusion: The dynamic pressure rapid thermal sterilization process can ensure that the microbial limit of Astragalus membranaceus, Panax notoginseng and other raw powders meet the requirements, and the effect is better than the conventional sterilization method. It is expected to replace the conventional sterilization technology of traditional Chinese medicine powder.

参考文献/References:

[1]　陈少平. 常用中药灭菌技术比较及其新技术介绍[J]. 中国民族民间医药，2013，22(6): 104. [2]　迟玉明. 中药原粉灭菌新技术研发及产业化应用研究[J]. 创新世界周刊，2021(1): 86-93. [3]　冯少俊，伍振峰，王雅琪，等. 中药灭菌工艺研究现状及问题分析[J]. 中草药，2015，48(18): 2667-2673. [4]　陈晓平，王建中. 不同灭菌方法对三七粉质量的影响[J].现代应用药学，1996(5): 22-24. [5]　王影，张德柱. 高压蒸汽灭菌法对三七细粉中3种成分含量的影响[J]. 中国药业，2014，23(7): 4-5. [6]　孙昱. 中药灭菌方法探讨[J]. 中国临床药理学杂志，2018(19): 2380-2382.

备注/Memo

备注/Memo:
【收稿日期】2022-02-08 【作者简介】罗琨炽（1985－），男，广西梧州制药（集团）股份有限公司工程师，从事药品技术研究工作。
更新日期/Last Update: 2022-07-18