[1]罗丽琼 王庆高.YKL-40在代谢性疾病和心血管疾病中的研究进展[J].大众科技,2022,24(03):86-90.
 Research Progress of YKL-40 in Metabolic Diseases and Cardiovascular Diseases[J].Popular Science & Technology,2022,24(03):86-90.
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YKL-40在代谢性疾病和心血管疾病中的 研究进展()
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《大众科技》[ISSN:1008-1151/CN:45-1235/N]

卷:
24
期数:
2022年03
页码:
86-90
栏目:
医药与卫生
出版日期:
2022-03-20

文章信息/Info

Title:
Research Progress of YKL-40 in Metabolic Diseases and Cardiovascular Diseases
作者:
罗丽琼1 王庆高2 
(1.广西中医药大学研究生院,广西 南宁 530001; 2.广西中医药大学第一附属医院,广西 南宁 530023)
关键词:
YKL-40代谢性疾病心血管疾病综述
Keywords:
YKL-40 metabolic diseases cardiovascular disease review
文献标志码:
A
摘要:
YKL-40是一种新发现的炎症性糖蛋白,近年来研究发现其不仅与炎性疾病有关,在代谢性疾病及心血管疾病中也均有高表达,并与全因死亡率及不良心血管结局密切相关。因此,YKL-40有望成为一种新的生物学标记物来预测代谢性疾病及心血管疾病的发生、发展及预后。文章就YKL-40与代谢性疾病及心血管疾病的近年研究结果进行总结,以期为代谢性疾病及心血管疾病的治疗提供参考。
Abstract:
YKL-40 is a newly discovered inflammatory glycoprotein. In recent years, it has been found that it is not only related to inflammatory diseases, but also highly expressed in metabolic diseases and cardiovascular diseases, and is closely related to all-cause mortality and adverse cardiovascular outcomes. Therefore, YKL-40 is expected to become a new biomarker to predict the occurrence, development and prognosis of metabolic diseases and cardiovascular diseases. This paper summarizes the recent research results of YKL-40, metabolic diseases and cardiovascular diseases, in order to provide reference for the treatment of metabolic diseases and cardiovascular diseases

参考文献/References:

[1] 中国心血管健康与疾病报告编写组. 中国心血管健康与疾病报告2020概要[J]. 中国循环杂志,2021,36(6): 521-545. [2] 周茜洋,唐春香,张龙江,等. 残余炎性心血管风险的研究进展[J]. 医学研究生学报,2020,33(7): 760-764. [3] Mazur M, Zielińska A, Grzybowski M M, et al. Chitinases and Chitinase-like proteins as therapeutic targets in inflammatory diseases, with a special focus on inflammatory bowel diseases[J]. International Journal of Molecular Sciences, 2021, 22(13): 6966. [4] Liu X, Zhang J, Zhu K Y. Chitin in arthropods: biosynthesis, mModification, and metabolism[J]. Advances in Experimental Medicine and Biology, 2019, 1142: 169-207. [5] 邢玉,郭靖涛,盖鲁粤. 人软骨糖蛋白-39与冠心病关系的研究进展[J]. 解放军医学院学报,2017,38(1): 92-95. [6] Rathcke C N, Vestergaard H. YKL-40, a new inflammatory marker with relation to insulin resistance and with a role in endothelial dysfunction and atherosclerosis[J]. Inflammation Research, 2006, 55(6): 221-227. [7] 蔡琼,韩辉武,彭珊珊,等. 心血管病住院患者代谢综合征与ASCVD的风险因素分析[J]. 中国医药导报,2020,17(14): 57-60. [8] Akbo? M K, Yal?#305n R, ?hinarslan A, et al. Increased serum YKL-40 level is associated with the presence and severity of metabolic syndrome[J]. The Anatolian Journal of Cardiology, 2016, 16(12): 953-958. [9] 于叶叶,石鑫,谭丽艳,等. 代谢综合征患者血清YKL-40水平变化及意义[J]. 黑龙江医药科学,2018,41(1): 32-34. [10] 陈迪芳,林金秀. 代谢综合征患者人软骨糖蛋白-3浓度变化及与危险因素个数的关系[J]. 中国循环杂志,2014,29(3): 201-205. [11] 聂秋平,刘美霞. 肥胖与心血管疾病相关性的研究进展[J]. 国际心血管病杂志,2018,45(1): 27-30. [12] Catalán V, Gómez-Ambrosi J, Rodríguez A, et al. Peripheral mononuclear blood cells contribute to the obesity-associated inflammatory state independently of glycemic status: involvement of the novel proinflammatory adipokines chemerin, chitinase-3-like protein 1, lipocalin-2 and osteopontin[J]. Genes and Nutrition, 2015, 10(3): 460. [13] Catalán V, Gómez-Ambrosi J, Rodríguez A, et al. Increased circulating and visceral adipose tissue expression levels of YKL-40 in obesity-associated type 2 diabetes are related to inflammation: impact of conventional weight loss and gastric bypass[J]. Journal of Clinical Endocrinology and Metabolism, 2011, 96(1): 200-209. [14] Hempen M, Kopp H P, Elhenicky M, et al. YKL-40 is elevated in morbidly obese patients and declines after weight loss[J]. Obesity Surgery, 2009, 19(11): 1557-1563. [15] 钮利娟. 血清人软骨糖蛋白-39(YKL-40)与2型糖尿病的相关性研究[D]. 苏州,苏州大学,2013. [16] Lee H, Kang R, Jee S H, et al. A promoter polymorphism-2122 C>T of CHI3L1 is associated with serum low density lipoprotein cholesterol level in Korean subjects[J]. Clinical Biochemistry, 2010, 43(15): 1195-1200. [17] Thomsen S B, Rathcke C N, Skaaby T, et al. The Association between genetic variations of CHI3L1, levels of the encoded glycoprotein YKL-40 and the lipid profile in a Danish population[J]. PLoS One, 2012, 7(10): e47094. [18] Kjaergaard A D, Johansen J S, Bojesen S E, et al. Elevated plasma YKL-40, lipids and lipoproteins, and ischemic vascular disease in the general population published correction appears in stroke[J]. Stroke, 2015, 46(2): 329-335. [19] 张纯燕,王冬,张慎和. 2型糖尿病合并冠心病冠状动脉特点及危险因素分析[J]. 解放军医药杂志,2019,31(4): 64-66. [20] Smekal A, Vaclavik J. Adipokines and cardiovascular disease: a comprehensive review[J]. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub, 2017, 161(1): 31-40. [21] 刘海蔚,陈道雄,陈开宁,等. 肥胖2型糖尿病患者血清几丁质酶3样蛋白1水平与胰岛素抵抗指数及糖化血红蛋白关系的研究[J]. 中国糖尿病杂志,2019,27(12): 900-902. [22] 董丽,杨丽霞,郭海霞,等. 血清胆红素、YKL-40、HMGB-1对糖尿病合并冠心病患者的临床意义[J]. 现代生物医学进展,2019,19(20): 3973-3976,3981. [23] Rathcke C N, Johansen J S, Vestergaard H. YKL-40, a biomarker of inflammation, is elevated in patients with type 2 diabetes and is related to insulin resistance[J]. Inflammation Research, 2006, 55(2): 53-59. [24] Luo W, Zhang L, Sheng L, et al. Increased levels of YKL-40 in patients with diabetes mellitus: a systematic review and meta-analysis[J]. Diabetology and Metabolic Syndrome, 2021, 13(1): 6. [25] Persson F, Rathcke C N, Gall M A, et al. High YKL-40 levels predict mortality in patients with type 2 diabetes[J]. Diabetes Research and Clinical Practice, 2012, 96(1): 84-89. [26] 周言. 原发性高血压靶器官损害YKL-40、PTX-3的相关性研究[D]. 衡阳: 南华大学,2014. [27] 赵萌萌. 人软骨糖蛋白39与原发性高血压早期心血管损伤的相关性研究[D]. 济南: 山东大学,2018. [28] 马伟红. 原发性高血压患者人软骨糖蛋白39(YKL-40)与动脉粥样硬化的相关性研究[D]. 济南: 山东大学,2011. [29] Xu T, Zhong C, Wang A, et al. YKL-40 level and hypertension incidence: a population-based nested case-control study in China[J]. Journal of the American Heart Association, 2016, 5(11): e004534. [30] Xu T, Zhong C, Wang A, et al. YKL-40 is a novel biomarker for predicting hypertension incidence among prehypertensive subjects: a population-based nested case-control study in China[J]. Clinica Chimica Acta, 2017, 472: 146-150. [31] ?tin M, Erdo?n T, K??#351 T, et al. Elevated serum YKL40 level is a predictor of MACE during the long-term follow up in hypertensive patients[J]. Clinical and Experimental Hypertension, 2020, 42(3): 271-274. [32] Khambhati J, Engels M, Allard-Ratick M, et al. Immunotherapy for the prevention of atherosclerotic cardiovascular disease: promise and possibilities[J]. Atherosclerosis, 2018, 276: 1-9. [33] Tall A R. Plasma high density lipoproteins: therapeutic targeting and links to atherogenic inflammation[J]. Atherosclerosis, 2018, 276: 39-43. [34] Ruscica M, Ferri N, Macchi C, et al. Lipid lowering drugs and inflammatory changes: an impact on cardiovascular outcomes[J]. Annals of Medicine 2018, 50(6): 461-484. [35] Montarello N J, Nguyen M T, Wong D T L, et al. Inflammation in coronary atherosclerosis and its therapeutic implications[J]. Cardiovascular Drugs and Therapy, 2020, 11: 10. [36] Boot R G, van Achterberg T A, van Aken B E, et al. Strong induction of members of the chitinase family of proteins in atherosclerosis: chitotriosidase and human cartilage gp-39 expressed in lesion macrophages[J]. Arteriosclerosis, Thrombosis, and Vascular Biology, 1999, 19(3): 687-694. [37] Michelsen A E, Rathcke C N, Skjelland M, et al. Increased YKL-40 expression in patients with carotid atherosclerosis [J]. Atherosclerosis, 2010, 211(2): 589-595. [38] Tan Y, Ji X, Mo Z, et al. Serum YKL-40 positively correlates with MMP-9 and CRP in patients with acute ST segment elevation myocardial infarction following emergency treatment[J]. Medicine, 2019, 98(47): e17950. [39] 张帆,刘俊明. YKL-40在冠状动脉粥样硬化性心脏病的致病机制研究动态[J]. 心肺血管病杂志,2013,32(2): 227-229. [40] Rathcke C N, Vestergaard H. YKL-40, a new inflammatory marker with relation to insulin resistance and with a role in endothelial dysfunction and atherosclerosis[J]. Inflammation Research, 2006, 55(6): 221-227. [41] 刘欣,牛慧敏,张明明,等. 血清YKL-40蛋白水平与颈动脉斑块内新生血管形成的关系[J]. 卒中与神经疾病,2017,24(5): 398-401,415. [42] 王超. YKL-40,hs-CRP及HCY在冠心病患者的表达水平分析[D]. 张家口: 河北北方学院,2018. [43] 李珍珍,李倩,荆晶,等. 几丁质酶-3样蛋白-1与冠心病患者冠脉病变狭窄程度的相关性分析[J]. 解放军医学院学报,2018,39(10): 853-856. [44] Jin Y, Cao J N, Wang C X, et al. High serum YKL-40 level positively correlates with coronary artery disease[J]. Biomarkers in Medicine, 2017, 11(2): 133-139. [45] ?iborski K, Kuliczkowski W, Karolko B, et al. Plasma YKL-40 levels correlate with the severity of coronary atherosclerosis assessed with the SYNTAX score[J]. Polish Archives of Internal Medicine, 2018, 128(11): 644-648. [46] 田婷婷,周明艳,伦立民. AMI患者血清甲壳质酶蛋白-40水平与心室重构的相关性分析[J]. 国际检验医学杂志,2018,39(21): 2633-2636. [47] 周辰旭. 急性ST段抬高型心肌梗死患者血清YKL-40的变化及意义[D]. 大连: 大连医科大学,2019. [48] Schroder J, Jakobsen J C, Winkel P, et al. Prognosis and reclassification by YKL-40 in stable coronary artery disease[J]. Journal of the American Heart Association, 2020, 9(5): e014634. [49] 白银龙,贾永平,郭贝贝. 冠心病病人PCI术后血清YKL-40及hs-CRP变化与预后的相关性研究[J]. 中西医结合心脑血管病杂志,2017,15(16): 1999-2002. [50] Yang L, Dong H, Lu H, et al. Serum YKL-40 predicts long-term outcome in patients undergoing primary percutaneous coronary intervention for ST-segment elevation myocardial infarction[J]. Medicine, 2019, 98(12): e14920. [51] Harada M, Nattel S. Implications of inflammation and fibrosis in atrial fibrillation pathophysiology[J]. Journal of Cardiac Electrophysiology. 2021, 13(1): 25-35. [52] 王山山,梁兆光. 炎症反应与心房颤动的关系[J]. 心血管病学进展,2019,40(5): 770-773. [53] 孙静美,尹德春,曲秀芬. 炎症信号与心房颤动[J]. 心血管病学进展,2020,41(1): 31-34. [54] ichelakakis N, Neroutsos G J, Perpinia A S, et al. Chitinase-3-like protein-1 (YKL-40) before and after therapy in supraventricular arrhythmias[J]. Journal of Cardiovascular Medicine, 2017, 18(9): 650-654. [55] Henningsen K M, Therkelsen S K, Johansen J S, et al. Plasma YKL-40, a new biomarker for atrial fibrillation [J]. Europace, 2009, 11(8): 1032-1036. [56] Wang Q, Shen H, Min J, et al. YKL-40 is highly expressed in the epicardial adipose tissue of patients with atrial fibrillation and associated with atrial fibrosis[J]. Journal of Translational Medicine, 2018, 16(1): 229. [57] Marott S C, Benn M, Johansen J S, et al. YKL-40 levels and atrial fibrillation in the general population[J]. International Journal of Cardiology, 2013, 167(4): 1354-1359. [58] Henningsen K M, Nilsson B, Johansen J S, et al. Plasma YKL-40 is elevated in patients with recurrent atrial fibrillation after catheter ablation[J]. Inflammation Research, 2010, 59(6): 463-469. [59] Bilim O, Takeishi Y, Kitahara T, et al. Serum YKL-40 predicts adverse clinical outcomes in patients with chronic heart failure[J]. Journal of Cardiac Failure, 2010, 16(11): 873-879. [60] 卓裕丰,程颖,解强,等. 慢性心力衰竭与几丁质酶-3样蛋白-1的相关性探讨[J]. 广州医学院学报,2013,41(1): 7-9. [61] Rathcke C N, Kistorp C, Raymond I, et al. Plasma YKL-40 levels are elevated in patients with chronic heart failure[J]. Scandinavian Cardiovascular Journal, 2010, 44(2): 92-99. [62] Harutyunyan M, Christiansen M, Johansen J S, et al. The inflammatory biomarker YKL-40 as a new prognostic marker for all-cause mortality in patients with heart failure[J]. Immunobiology, 2012, 217(6): 652-656.

备注/Memo

备注/Memo:
【收稿日期】2021-12-23 【作者简介】罗丽琼(1994-),女,广西中医药大学在读硕士研究生,研究方向为中西医结合防治心血管疾病。 【通信作者】王庆高(1971-),男,广西中医药大学第一附属医院心血管内科主任医师,博士,硕士研究生导师,研究方向为中西医结合防治心血管疾病。
更新日期/Last Update: 2022-06-21