[1]卢　帅　王庆高　黄冬欢　袁冬梅　罗丽琼　毛志华　唐丽秋.无创心功能检查对高血压病合并动脉硬化风险的预测价值[J].大众科技,2021,23(12):46-50.
　Value of Noninvasive Cardiac Function Examination in Predicting the Risk of Hypertension Complicated with Arteriosclerosis[J].Popular Science & Technology,2021,23(12):46-50.
点击复制

无创心功能检查对高血压病合并动脉硬化 风险的预测价值()
分享到：

《大众科技》[ISSN:1008-1151/CN:45-1235/N]

卷:
23
期数:
2021年12
页码:
46-50
栏目:
医药与卫生
出版日期:
2021-12-20

文章信息/Info

Title:
Value of Noninvasive Cardiac Function Examination in Predicting the Risk of Hypertension Complicated with Arteriosclerosis
作者:
卢　帅1　王庆高2　黄冬欢1　袁冬梅1　罗丽琼1　毛志华1　唐丽秋1　
（1.广西中医药大学研究生学院，广西 南宁 530001； 2.广西中医药大学第一附属医院，广西 南宁 530023）
关键词:
高血压病; 无创心功能检查; 动脉硬化 ; 阻抗
Keywords:
hypertension noninvasive cardiac function examination arteriosclerosis impedance
文献标志码:
A
摘要:
目的：探讨无创心功能检查对高血压病合并动脉硬化风险的预测价值。方法：50名高血压患者和24名非高血压患者为研究对象，采用无创心功能检查测量，比较各组指标差异，并进行ROC曲线计算。结果：高血压患者LTPF、CR、LCI、JP、VP、PDM、PSM、CMO等明显高于对照组（P＜0.05）；高血压组动脉硬化亚组较非动脉硬化亚组LTPT、CR明显增高（P＜0.05）；对高血压亚组中有意义的指标进行多因素logistic回归分析提示，LTPT（OR＝2.398，P＝0.021），CR（OR＝1.047，P＝0.034），与高血压发生动脉硬化风险呈正相关；对LTPT、CR进行ROC曲线分析， AUC分别为0.749、0.727，对动脉硬化有较好的预测价值。结论：无创心功能检查对高血压早期干预及治疗具有指导意义，LTPT、CR与高血压合并动脉硬化风险呈正相关，对动脉硬化有较好预测价值。
Abstract:
Objective: To explore the value of noninvasive cardiac function examination in predicting the risk of hypertension complicated with arteriosclerosis. Methods: 50 patients with hypertension and 24 patients with non hypertension were measured by noninvasive cardiac function test, the differences of indexes in each group were compared, and the ROC curve was calculated. Results: LTPF, CR, LCI, JP, VP, PDM, PSM and CMO in patients with hypertension were significantly higher than those in the control group (P< 0.05) LTPT and CR in arteriosclerosis subgroup of hypertension group were significantly higher than those in non arteriosclerosis subgroup (P＜0.05) multivariate logistic regression analysis showed that LTPT (OR=2.398, P=0.021) and CR(OR=1.047, P = 0.034) were positively correlated with the risk of arteriosclerosis in hypertension ROC curve analysis of ltpt and CR showed that AUC were 0.749 and 0.727 respectively, which had good predictive value for arteriosclerosis. Conclusion: Noninvasive cardiac function examination has guiding significance for early intervention and treatment of hypertension. LTPT and CR are positively correlated with the risk of hypertension complicated with arteriosclerosis, and have good predictive value for arteriosclerosis.

参考文献/References:

[1] Wang Z, Chen Z, Zhang L, et al. Status of hypertension in China: results from the China Hypertension Survey, 2012-2015[J]. Circulation, 2018 137(22): 2344-2356. [2] Wang J G. et al. Unique approaches to hypertension control in China[J]. Annals of Translational Medicine, 2018 6(15): 296. [3] Guzik T J, Skiba D S, Touyz R M, et al. The role of infiltrating immune cells in dysfunctional adipose tissue[J]. Cardiovascular Research, 2017 113(9): 1009-1023. [4] Chirinos J A, Segers P, Hughes T, et al. Large-artery stiffness in health and disease: JACC state-of-the-art review [J]. Journal of the American College of Cardiology, 2019, 74(9): 1237-1263. [5] Vlachopoulos C, Aznaouridis K, Terentes-Printzios D, et al. Prediction of cardiovascular events and all-cause mortality with brachial-ankle elasticity index: a systematic review and meta-analysis[J]. Hypertension, 2012 60(2): 556-562. [6] 中国高血压防治指南修订委员会，高血压联盟(中国)，中华医学会心血管病学分会. 中国高血压防治指南(2018年修订版)[J]. 中国心血管杂志，2019，24(1): 24-56. [7] 中国社工协会康复医学工作委员会血管专业委员会，国际血管健康学会中国分会，北京大学首钢医院血管医学中心. 中国血管病变早期检测技术应用指南(2011第二次报告)[J]. 心血管病学进展，2011，32(3): 318-323. [8] Smith R D, Levy P, Ferrario, C M. Value of noninvasive hemodynamics to achieve blood pressure control in hypertensive subjects[J]. Hypertension, 2006, 47(4): 771-777. [9] 李世锋，张芳芳，王晶晶，等. 心功能检查对妊娠期高血压诊断价值[J]．中国实用神经疾病杂志，2019，22(7): 754-757. [10] 王淑琴，王悦岩，李雪梅，等. 对120例高血压病患者血流动力学分型探讨[J]. 心脏杂志，2000，12(5): 424. [11] Aoka Y, Hagiwara N, Kasanuki H. Heterogeneity of hemodynamic parameters in untreated primary hypertension, and individualization of antihypertensive therapy based on noninvasive hemodynamic measurements[J]. Clinical and Experimental Hypertension, 2013, 35(1): 61-66. [12] Sharman D L, Gomes C P, Rutherford J P. Improvement in blood pressure control with impedance cardiograph- guided pharmacologic decision making[J]. Congestive heart failure, 2004, 10(1): 54-58. [13] Fadl Elmula F E, Rebora P, Talvik A, et al. A randomized and controlled study of noninvasive hemodynamic monitoring as a guide to drug treatment of uncontrolled hypertensive patients[J]. Journal of Hypertension, 2015, 33(12): 2534-2545. [14] Cavalcante J L, Lima J A., Redheuil A, et al. Aortic stiffness: current understanding and future directions[J]. Journal of the American College of Cardiology, 2011, 57(14): 1511-1522. [15] Vlachopoulos C, Aznaouridis K, Terentes-Printzios D, et al. Prediction of cardiovascular events and all-cause mortality with brachial-ankle elasticity index: a systematic review and meta-analysis[J]. Hypertension, 2012, 60(2): 556-562. [16] Tomiyama H, Matsumoto C, Shiina K, et al. Brachial-Ankle P W V: Current status and future directions as a useful marker in the management of cardiovascular disease and/or cardiovascular risk factors[J]. Journal of Atherosclerosis and Thrombosis, 2016, 23(2): 128-146. [17] Najjar S S, Scuteri A, Wright J G, et al. Pulse wave velocity is an independent predictor of the longitudinal increase in systolic blood pressure and of incident hypertension in the Baltimore Longitudinal Study of Aging[J]. Journal of the American College of Cardiology, 2008, 51(14): 1377-1383. [18] Huanga Z, Wang G D, Jonas J B, et al. Blood pressure control and progression of arteriosclerosis in hypertension [J]. Journal of Hypertension, 2021, 39(6): 1221-1229 . [19] Lin H H, Wang C S, Lin J L, et al. Effects of anti-hypertensive monotherapy with either calcium channel blocker or angiotensin receptor blocker on arterial stiffness, central hemodynamics, and ventriculo-arterial coupling in uncomplicated hypertension patients[J]. Acta Cardiologica Sinica, 2013, 29(1): 19-27. [20] Solini A, Giannini L, Seghieri M, et al. Dapagliflozin acutely improves endothelial dysfunction, reduces aortic stiffness and renal resistive index in type 2 diabetic patients: a pilot study[J]. Cardiovascular Diabetology, 2017, 16(1): 138. [21] Boutouyrie P, Lacolley P, Briet M, et al. Pharmacological modulation of arterial stiffness[J]. Drugs, 2011, 71(13): 1689-1701. [22] Dudenbostel T, Glasser S P. Effects of antihypertensive drugs on arterial stiffness[J]. Nature Reviews Cardiology, 2012, 20(5): 259-263. [23] Ye Z, Coutinho T, Pellikka P A, et al. Associations of alterations in pulsatile arterial load with left ventricular longitudinal strain[J]. American Journal of Hypertension, 2015, 28(11): 1325-1331. [24] Pavlopoulos H, Nihoyannopoulos P. Pulse pressure/stroke volume: a surrogate index of arterial stiffness and the relation to segmental relaxation and longitudinal systolic deformation in hypertensive disease[J]. European Journal of Echocardiography, 2009, 10(4): 519-526. [25] Palmieri V, Bella J N, Roman M J, et al. Pulse pressure/stroke index and left ventricular geometry and function: the LIFE Study[J]. Journal of Hypertension, 2003, 21(4): 781-787. [26] Kuhl H P. Hypertrophic cardiomyopathy, fibrosis, and aortic stiffness: an unidentified association unraveled by magnetic resonance imaging[J]. Journal of the American College of Cardiology, 2009, 54(3): 263-264. [27] Weir-McCall J R. Lambert M, Gandy S J, et al. Systemic arteriosclerosis is associated with left ventricular remodeling but not atherosclerosis: a TASCFORCE study [J]. Journal of Cardiovascular Magnetic Resonance, 2018, 20(1): 7.

相似文献/References:

[1]覃裕旺,许明东.痰瘀互结型高血压病的中医治疗研究进展[J].大众科技,2013,15(07):127.
[2]赵 旋 李成林 张远照 邓嘉星.高血压病合并高脂血症的中医药治疗研究进展[J].大众科技,2018,20(11):59.
　Research Progress in the Treatment of Hypertension with Hyperlipidemia by Traditional Chinese Medicine[J].Popular Science & Technology,2018,20(12):59.
[3]叶 雲,周至品.NLRP3 炎症小体与高血压病的相关性研究[J].大众科技,2020,22(03):68.
　Study on the Correlation Between NLRP3 Inflammatory Corpuscles andHypertension[J].Popular Science & Technology,2020,22(12):68.
[4]许明东 岳桂华.数据挖掘在处理高血压病中医诊疗信息中的应用进展[J].大众科技,2020,22(09):91.
　Application Progress of Data Mining in Processing TCM Diagnosis and Treatment Information of Hypertension[J].Popular Science & Technology,2020,22(12):91.

备注/Memo

备注/Memo:
【收稿日期】2021-10-14 【基金项目】广西科技厅重点研发计划项目（桂科 AB17195054）；广西中医药大学校级硕士研究生科研创新项目（YCXJ2021040）。 【作者简介】卢帅（1996－），男，广西中医药大学研究生学院在读硕士研究生，研究方向为中西医结合防治心血管疾病。 【通信作者】王庆高（1971－），男，广西中医药大学第一附属医院教授，博士，研究生导师，从事中西医结合防治心血管疾病的基础与临床研究。
更新日期/Last Update: 2022-04-07