[1]叶 雲,周至品.NLRP3 炎症小体与高血压病的相关性研究[J].大众科技,2020,22(03):68-71.
 Study on the Correlation Between NLRP3 Inflammatory Corpuscles andHypertension[J].Popular Science & Technology,2020,22(03):68-71.
点击复制

NLRP3 炎症小体与高血压病的相关性研究()
分享到:

《大众科技》[ISSN:1008-1151/CN:45-1235/N]

卷:
22
期数:
2020年03
页码:
68-71
栏目:
医药与卫生
出版日期:
2020-03-20

文章信息/Info

Title:
Study on the Correlation Between NLRP3 Inflammatory Corpuscles andHypertension
作者:
叶 雲12 周至品 3
(1.广西中医药大学,广西 南宁 530200;2.中国人民解放军 923 医院,广西 南宁 530023;3.广西中医药大学附属瑞康医院,广西 南宁 530001)
关键词:
高血压病NLRP3 炎症小体综述
Keywords:
hypertension NLRP3 inflammatory corpuscles review
文献标志码:
A
摘要:
高血压病是一种慢性的低级别炎症性疾病,NLRP3 炎症小体是固有免疫的重要组成部分,近年来越来越多的研究证实,两者存在着密切的关系。NLRP3 炎症小体的激活,可以导致其下游的 IL-1β和 IL-18 强致炎因子的释放,引起血管内皮细胞功能障碍。血管内皮功能障碍被认为是高血压病、动脉血管粥样硬化等心血管事件的起始环节,此外,由 IL-1β诱导 Ang II表达的上调,被认为是引起高血压上升的直接因素之一;在 Ang II 的作用下,诱导的血管收缩重塑,是高血压病的一种显著性病理特征,在一系列复杂的生理病理网络协同作用下,引起心、脑、肾等靶器官损伤,诱发高血压众多的并发症。文章现就 NLRP3炎症小体与高血压病的相关性的研究进展进行综述。
Abstract:
hypertension is a chronic low-grade inflammatory disease. NLRP3 inflammatory is an important part of innate immunity. Inrecent years, more and more studies have confirmed that there is a close relationship between them. The activation of NLRP3 inflammatorycorpuscles can lead to the release of IL-1β and IL-18 strong inflammatory factors downstream of NLRP3, and cause endothelial celldysfunction. Vascular endothelial dysfunction is considered to be the starting link of cardiovascular events such as hypertension andatherosclerosis. In addition, the up regulation of Ang II expression induced by IL-1 β is considered to be one of the direct factors causing therise of hypertension. Under the action of Ang II, the induced vasoconstriction and remodeling is a significant pathological feature ofhypertension. Under the coordination of a series of complex physiological and pathological networks, it causes the damage of heart, brain,kidney and other target organs, and induces many complications of hypertension. This article reviews the research progress of thecorrelation between NLRP3 inflammatory corpuscles and hypertension.

参考文献/References:

[1] Oktay A A,Akturk H K,Jahangir E. Diabetes mellitus andhypertension: a dual threat[J]. Current Opinion inCardiology, 2016, 31(4): 402-409.[2] Abbasi S H,Mohammadinejad P,Shahmansouri N, et al.Simvastatin versus atorvastation for improving mild tomoderate depression in post-coronary artery bypass graftpatients:A double-blind, place- bocontrolled, randomizedtrial[J]. Journal of Affective Disorders, 2015, 183: 149-155.[3] 陈明,陈志武,龙子江. 炎性标志物对心血管疾病风险性的预测及意义[J]. 心血管病学进展,2013(2): 290-295.[4] Paolo P, Marcello R. Inflammation and hypertension: thesearch for a link[J]. Nephrology Dialysis Transplantation,2006, 21(4): 850-853.[5] De Miguel C, Rudemiller N P, Abais J M, et al.Inflammation and hypertension: new understandings andpotential therapeutic targets[J]. Current HypertensionReports, 2015, 17(1): 507.[6] Riteau N, Baron L, Villeret B, et al. ATP release andpurinergic signaling: a common pathway for particle-mediated inflammasome activation[J]. Cell Death andDisease, 2012, 3(10): e403.[7] Lamkanfi M, Dixit V M. Mechanisms and functions ofinflammasomes[J]. Cell, 2014, 157(5): 1013-1022.[8] Elinav E, Henao-Mejia J, Flavell R A. Integrativeinflammasome activity in the regulation of intestinalmucosal immune responses[J]. Mucosal Immunology, 2013,6(1): 4-13.[9] 李岐佩,阎仿,刘婷婷,等. NLRP3 与妊娠高血压孕妇心功能的相关性[J]. 中国医学前沿杂志(电子版),2019(9): 155-158.[10] 胡剑苗,王青. 妊娠高血压疾病及并发症对母婴妊娠结局的影响[J]. 中国妇幼保健,2017,32(21): 5272-5274.[11] Koumei S, Tadayoshi K, Fumitake U, et al. NLRP3Deficiency Improves Angiotensin II-Induced HypertensionBut Not Fetal Growth Restriction During Pregnancy[J].Endocrinology, 2015,156(11): 4281-4292.[12] 黄丛富. 肾脏中NLRP3炎性体在孕期LPS刺激致子代大鼠高血压中的作用研究[D]. 洛阳: 河南科技大学,2017.[13] Dornas W. C, Silva M E. Animal models for the study ofarterial hypertension[J]. Journal of Biosciences, 2011,36(4): 731-737.[14] Qi J, Yu X J, Shi X L, et al. NF-κB blockade inhypothalamic paraventricular nucleus inhibits high-salt-induced hypertension through NLRP3 and caspase-1[J].Cardiovascular Toxicology, 2016, 16(4): 345-354.[15] Zhao X J, Yang Y Z, Zheng Y J, et al. Magnesiumisoglycyrrhizinate blocks fructose-induced hepatic NF-κB/NLRP3 inflammasome activation and lipid metabolismdisorder[J]. European Journal of Pharmacology, 2017,8(15): 141-150.[16] Xia M, Abais J M, Koka S, et al. Characterization andactivation of NLRP3 inflammasomes in the renal medulla inmice[J]. Kidney & Blood Pressure Research, 2016, 41(2):208-221.[17] Krishnan S M, Dowling J K, Ling Y H, et al. Inflammasomeactivity is essential for one kidney /deoxycorticosteroneacetate /salt-induced hypertension in mice[J]. BritishJournal of Pharmacology, 2015, 173(4): 752.[18] Zhu Q, Li X X, Wang W, et al. Mesenchymal stem celltransplantation inhibited high salt-induced activation of theNLRP3 inflammasome in the renal medulla in Dahl Srats[J]. American Journal of Physiology Renal Physiology,2016, 310(7): 621-627.[19] Toshiki D, Shigehiro D, Ayumu N, et al. Mizoribine- 71 -Ameliorates Renal Injury and Hypertension along with theAttenuation of Renal Caspase-1 Expression in Aldosterone-Salt-Treated Rats[J]. PloS One, 2014, 9(4): e93513.[20] 朱建,张源明,郁洁,等. 新疆哈萨克族高血压患者外周血单个核细胞炎症激活与 NLRP3 炎症体通路相关性研究[J]. 临床心血管病杂志,2015(9): 80-84.[21] 朱建,张源明,郁洁,等. NLRP3 炎症小体信号通路相关分子在新疆哈萨克族高血压患者外周血 T 淋巴细胞中的表达[J]. 中华高血压杂志,2015,23(1): 67-72.[22] 陈晨,蒋汝红. NLRP3 炎性小体在高血压患者早期心肌功能损伤中的作用[J]. 中华全科医学,2018,16(11): 65-67.[23] Wang Q, So A, Nussberger J, et al. Impact of NLRP3inflammasome on the development of hypertension andrenal and cardiac hypertrophy in 2K1C and DOCA/saltmice[J]. Kidney Research and Clinical Practice, 2012,31(2): A83.[24] Krishnan S M , Ling Y H , Huuskes B M, et al.Pharmacological inhibition of the NLRP3 inflammasomereduces blood pressure, renal damage and dysfunction insalt-sensitive hypertension[J]. Cardiovascular research,2018, 115(4): 776-787.[25] 阿希,李玉琳,王绿娅,等. 炎症小体 Nlrp3 在高血压小鼠心肌纤维化中的作用[J]. 心肺血管病杂志,2015,34(6): 496-500.[26] 翟昌明,鲁放,张双,等. 三草降压汤对自发性高血压大鼠心脏 NF-κB/NLRP3/IL-1β 信号通路的影响[J]. 环球中医药,2019(8): 1143-1148.[27] Ren X S, Tong Y, Ling L, et al. NLRP3 Gene DeletionAttenuates Angiotensin II-Induced Phenotypi Transformationof Vascular Smooth Muscle Cells and Vascular Remodeling[J]. Cellular Physiology & Biochemistry, 2017, 44(6):2269-2280.[28] Sun H J, Ren X S, Xiong X Q, et al. NLRP3 inflammasomeactivation contributes to VSMC phenotypic transformationand proliferation in hypertension[J]. Cell Death andDisease, 2017, 8(10): e3074.[29] 杨仁强,黄玲,马晓欣,等. NLRP3 炎症小体介导血管紧张素Ⅱ诱导的人脐静脉血管内皮细胞炎症因子 IL-1β的表达[J]. 南方医科大学学报,2016,36(6): 790-795.[30] 胡琴. 二氢杨梅素通过 Nrf2 抑制 NLRP3 炎性体调控的血管内皮细胞焦亡的作用及机制研究[D]. 重庆: 第三军医大学,2017.[31] 李佳宝. 硫化氢改善自发性高血压大鼠肾动脉内皮功能紊乱及其机制研究[D]. 石家庄: 河北医科大学,2017.[32] 马秀英,戴晨,张源明,等. NLRP3 基因多态性与哈萨克族老年原发性高血压的关系[J]. 中国临床研究,2018,31(5): 585-588.[33] 马秀英,张源明,戴晨,等. 核苷酸结合寡聚结构域样受体蛋白 3 基因多态性与哈萨克族高血压颈动脉粥样硬化的关系[J]. 中华老年心脑血管病杂志,2018,20(1):30-33.[34] Omi T, Kumada M, Kamesaki T, et al. An intronic variablenumber of tandem repeat polymorphisms of the cold-induced autoinflammatory syndrome 1 (CIAS1) genemodifies gene expression and is associated with essentialhypertension[J]. European Journal of Human Genetics,2006, 14(12): 1295-1305.[35] Kunnas T, Mtt K, Nikkari S T, NLR family pyrin domaincontain 3(NLRP3) in-flammasome NLR family pyrindomain containing 3 (NLRP3) inflammasome genepolymorphism rs7512998(C > T) predicts aging-relatedincrease of blood pressure, the TAMRISK study[J].Immunity and Ageing, 2015, 12(19): 1-5.[36] 马玉珍,彭朋,秦永生,等. NLRP3 炎性小体抑制剂VX-765 对急性心肌梗死大鼠心功能及线粒体能量代谢的影响[J]. 武警后勤学院学报(医学版),2017,26(9):742-745.

相似文献/References:

[1]覃裕旺,许明东.痰瘀互结型高血压病的中医治疗研究进展[J].大众科技,2013,15(07):127.
[2]赵 旋 李成林 张远照 邓嘉星.高血压病合并高脂血症的中医药治疗研究进展[J].大众科技,2018,20(11):59.
 Research Progress in the Treatment of Hypertension with Hyperlipidemia by Traditional Chinese Medicine[J].Popular Science & Technology,2018,20(03):59.
[3]许明东 岳桂华.数据挖掘在处理高血压病中医诊疗信息中的应用进展[J].大众科技,2020,22(09):91.
 Application Progress of Data Mining in Processing TCM Diagnosis and Treatment Information of Hypertension[J].Popular Science & Technology,2020,22(03):91.
[4]卢 帅 王庆高 黄冬欢 袁冬梅 罗丽琼 毛志华 唐丽秋.无创心功能检查对高血压病合并动脉硬化风险的预测价值[J].大众科技,2021,23(12):46.
 Value of Noninvasive Cardiac Function Examination in Predicting the Risk of Hypertension Complicated with Arteriosclerosis[J].Popular Science & Technology,2021,23(03):46.

备注/Memo

备注/Memo:
【收稿日期】2020-01-06【基金项目】国家自然科学基金项目(81860841);广西自然科学基金项目(2017GXNSFAA198295)。【作者简介】叶雲(1985—),广西中医药大学在读硕士研究生,中国人民解放军 923 医院主管医师,从事心血管药理研究。
更新日期/Last Update: 2020-05-22