[1]邓文仕,张家立,赵 犀,等.基于关联规则和复杂系统熵聚类的腰椎间盘突出症外治方剂组方分析和新方发现[J].大众科技,2020,22(01):65-68.
　Analysis and New Discovery of Prescriptions for External Treatment of LumbarDisc Herniation Based on Association Rules and Entropy Clustering of ComplexSystems[J].Popular Science & Technology,2020,22(01):65-68.
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基于关联规则和复杂系统熵聚类的腰椎间盘突出症外治方剂组方分析和新方发现()
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《大众科技》[ISSN:1008-1151/CN:45-1235/N]

卷:
22
期数:
2020年01
页码:
65-68
栏目:
医药与卫生
出版日期:
2020-01-20

文章信息/Info

Title:
Analysis and New Discovery of Prescriptions for External Treatment of LumbarDisc Herniation Based on Association Rules and Entropy Clustering of ComplexSystems
作者:
邓文仕;  张家立 ;  赵 犀 ;  廖俊城; 霍杰钊 ;  卢明毅
（1.广西中医药大学，广西 南宁 530001；2.广西中医药大学第一附属医院，广西 南宁 530023）
关键词:
腰椎间盘突出症; 聚类算法; 关联规则; 外治; 新方发现
Keywords:
lumbar disc herniation;  clustering algorithm;  association rules;  external treatment;  newer discovery
文献标志码:
A
摘要:
目的：基于中医传承辅助平台（TCMISS）挖掘中药方剂外用治疗腰椎间盘突出症（Lumbar disc herniation，LDH)的用药规律。方法：从中国知网等数据库公开发表的文献及专利中检索中药外用治疗 LDH 的处方，运用中医传承辅助系统软件中复杂系统熵聚类法、关联规则 Apriori 算法、无监督的熵层次聚类核心算法，获取中医药外治腰椎间盘突出症用药规律及新处方，并根据结果绘制用药图表。结果：对筛选出的 151 个处方进行分析，共使用中药 269 味，其中使用≥5 次的中药为 72 味，1542 味次，这 72 味常用中药按功效分为祛风湿药 19 味、活血化瘀药 17 味、补虚药 8 味、解表药 5 味，其他功效药各占少量比重，药味辛、苦、甘出现累计频率达 91.6%，药性以“温、平”为主，累计频率达 77.5%，药物归经以肝、脾、肾为主，累计频率达 62.6%。并基于改进互信息法提取关联规则 53 条，挖掘出了 LDH 外用处方核心组合 28 个和新处方 14 首。结论：组方用药以祛风湿药、活血化瘀药、补虚药为主，同时结合兼证辅以解表药、温里药、清热药、化痰开窍药、平肝息风药，常用中药主要归肝、脾、肾经，性味以辛、苦、甘、温平为主。TCMISS 是一个有价值的中医药研究辅助工具，可对中药处方的进行数据录入、管理、查询和分析，有利于中医中药的传承。
Abstract:
Objective: Based on TCM inheritance assistant platform (TCMIS), the rules of Chinese medicine prescription external usein the treatment of lumbar disc herniation (LDH) were explored. Method: The prescription of LDH for external use of traditional Chinesemedicine was searched from published literatures and patents of China knowledge network and other databases. The complex systementropy clustering method, association rule Apriori algorithm and unsupervised entropy hierarchical clustering core algorithm in thesoftware of traditional Chinese Medicine Inheritance auxiliary system were used to obtain the medication rules and new prescriptions ofexternal treatment of lumbar disc herniation with traditional Chinese medicine, and the medication charts were drawn according to theresults. Result: 151 selected prescriptions were analyzed，a total of 269 traditional Chinese medicines were used, 72 herbs were used for ≥5times，1542 flavors, according to their functions, the 72 commonly used Chinese medicines are divided into 19 herbs for removing windand dampness, 17 herbs for promoting blood circulation and removing blood stasis, 8 herbs for relieving deficiency, and 5 herbs for clearingthe surface, and a small proportion of other effective drugs, The cumulative frequency of bitter, bitter and sweet drug flavors reached 91.6%.The medicinal properties were mainly "warm and flat" with a cumulative frequency of 77.5%. The drug channel was mainly liver, spleenand kidney, with a cumulative frequency of 62.6%. Based on the improved mutual information method, 53 association rules were extracted,28 core combinations of LDH external prescriptions and 14 new prescriptions were excavated. Conclusions: The prescription is mainlyused for removing wind and dampness, promoting blood circulation and removing blood stasis, and supplementing deficiency. At the sametime, it is combined with table clearing drugs, warming li drugs, heat-clearing drugs, phlegm-clearing drugs and wind-soothing drugs.TCMISS is a valuable auxiliary tool for TCM research, which can be used for data entry, management, query and analysis of TCMprescriptions, and it is conducive to the inheritance of TCM.

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备注/Memo

备注/Memo:
【收稿日期】2019-11-13【作者简介】邓文仕（1992－），男，广西中医药大学硕士研究生，研究方向为中西医结合脊柱外科诊治。
更新日期/Last Update: 2020-05-21