[1]刘露露,潘子恒,彭 岳,等.TGF-β1/Smads 信号通路在肝纤维化中的调控作用概述[J].大众科技,2019,21(07):73-75.
　Overview of the Regulation of TGF-β1/Smads Signaling Pathway in Hepatic Fibrosis[J].Popular Science & Technology,2019,21(07):73-75.
点击复制

TGF-β1/Smads 信号通路在肝纤维化中的调控作用概述()
分享到：

《大众科技》[ISSN:1008-1151/CN:45-1235/N]

卷:
21
期数:
2019年07
页码:
73-75
栏目:
医药与卫生
出版日期:
2019-07-20

文章信息/Info

Title:
Overview of the Regulation of TGF-β1/Smads Signaling Pathway in Hepatic Fibrosis
作者:
刘露露1;  潘子恒 1;  彭 岳 2;  吕贝贝 1;  李文康 1;  郑 洋 1;  赵铁建 2
（1.广西中医药大学研究生学院, 广西 南宁 530200；2.广西中医药大学基础医学院，广西 南宁 530200）
关键词:
肝纤维化; TGF-β1; Smads; 信号通路
Keywords:
hepatic fibrosis;  TGF-β1;  Smads;  signaling pathway
文献标志码:
A
摘要:
与肝纤维化密切相关的转化生长因子（transforming growth factor beta1，TGF-β1）及其下游信号因子 Smads 家族蛋白既可促进肝星状细胞活化，又可调节细胞外基质合成与降解，从而控制肝纤维化的发生发展。而 TGF-β1/Smads 信号通路是 TGF-β1 促进肝纤维化的关键转导途径。文章就 TGF-β1/Smads 信号通路在肝纤维化中的调控作用综述，为肝纤维化的治疗提供参考。
Abstract:
Transforming growth factor beta1 (TGF-β1) and its downstream signal factor Smads family proteins, which are closelyrelated to liver fibrosis, can not only promote the activation of hepatic stellate cells, but also regulate the synthesis and degradation ofextracellular matrix, thus controlling the occurrence and development of liver fibrosis. TGF-beta 1/Smads signaling pathway is the keypathway of TGF-beta 1 promoting liver fibrosis. This article reviews the regulatory role of TGF-β1/Smads signaling pathway in hepaticfibrosis, providing a reference for the treatment of hepatic fibrosis.

参考文献/References:

[1] 舒建昌,潘洁.姜黄素抗肝纤维化作用及其机制的研究进展[J].国际消化病杂志,2007(4):239-241.[2] Dooley S,Dijke P ten.TGF-beta in progression of liverdisease[J].Cell & Tissue Research,2012,347(1):245- 256.[3] Bataller RBrenner D A.Liver fibrosis [J].Journal of ClinicalInvestigation,2005,115(2):209.[4] Lin J,Wu JF,Zhang Q,et al.Virus-related liver cirrhosis:Molecular basis and therapeutic options[J].World Journal ofGastroenterol,2014,20(21):6457-6469 .[5] Okazaki I,Noro T,Tsutsui N,et al.Fibrogenesis andCarcinogenesis in Nonalcoholic Steatohepatitis (NASH):Involvement of Matrix Metalloproteinases (MMPs) andTissue Inhibitors of Metalloproteinase(TIMPs)[J].Cancers,2014,6(3):1220-1255 .[6] Lachenmeier D W,Monakhova Y B,Rehm J.Influence ofunrecorded alcohol consumption on liver cirrhosis mortality[J].World Journal of Gastroenterol (WJG),2014,20(23):7217.[7] Lee E H,Park K,Kim K Y,et al.Liquiritigenin inhibitshepatic fibrogenesis and TGF-β1/Smad with Hippo/Yapsignal[J]. Phytomedicine,2018,62 (10):152780.[8] Elpek G O.Cellular and molecular mechanisms in thepathogenesis of liver fibrosis:An update [J].World Journalof Gastroenterol ,2014,20 (23):7260-7276 .[9] Drabsch Y,Dijke P.TGF-beta signalling and its role in cancerprogression and metastasis[J].Cancer and Metastasis Reviews,2012,31(3-4):554-562 .[10] Zhao S,Jiang J T,Li D,et al.Maternal exposure to di-n-butylphthalate promotes Snail1-mediated epithelial-mesenchymaltransition of renal tubular epithelial cells via upregulation ofTGF-β1 during renal fibrosis in rat offspring[J].Ecotoxicologyand Environmental Safety,2019, 169:266-272.[11] Dai J,Xu M,Zhang X,et al.Bi-directional regulation ofTGF-β/Smad pathway by arsenic:A systemic review andmeta-analysis of in vivo and in vitro studies[J].LifeSciences,2019,220:92-105.[12] Friedman S L.Mechanisms of hepatic fibrogenesis[J].Gas-troenterology,2008,134:1655-1669.[13] Lee U E,Scott L.Friedman.Mechanisms of hepaticfibrogenesis[J].Best Practice Research Clinical Gastroenterol,2011,25(2):195-206.[14] Geng Y,Wang J,et al.Screening and isolation for anti-hepatofibrotic components from medicinal mushroomsusing TGF-β1-induced live fibrosis in hepatic stellate cells[J].International Journal of Medicinal Mushrooms,2014,16(16):529-39.[15] Hu H H,Chen D Q,Wang Y N,et al.New insights intoTGF-β/Smad signaling in tissue fibrosis[J].ChemicBiological Interactions,2018,292:76.[16] Takahashi K,Murata S,Fukanaga K,et al.Human plate-letsinhibit liver fiborsis in severe combined immunodeficiencymice [J].World Journal of Gastroenterol,2013,19(32):5250-5260.[17] Nakamura T,Sakata R,Ueno T,et al.Inhition of trans-forminggrowth factor beta prevents progression of liver fibrosis andenhances hapatocyte Regeneration in dimethy Initrosamine-treatedrats[J].Hepatology,2000,32(2):247-255.[18] Verrecchia F,Mauviel A.Transforming growth factor-βsignaling through the Smad pathway:role in extracellularmatrix gene expression and regulation[J].Journal ofInvestigative Dermatology,2002,118(2):211-215.[19] 赵青,陈楠,周同.TGF-β诱导 CTGF 表达的信号转导途径与纤维化形成[J].生命科学,2003,15(3):155-158.[20] 刘成敏,张成仁,王秀梅.Smads 介导的 TGF-β信号转导通路与肿瘤关系的研究进展[J].中华肿瘤防治杂志,2010,17(8):631-634.[21] Moustkas A,Heldin CH.The regulation of TGF-beta signaltransduction[J] .Development,2012,136 :3699-3714 .[22] Zhang L,Liu C,Meng XM,etal.Smad2 protects againstTGF-beta 1/Smad 3-mediated collagen synthesis in humanhe-patic stellate cells during hepatic fibrosis[J].Molecularand Cellular Biochemistry,2015(400):17-28 .[23] Uemura M,Swenson ES,Gaca MD,et al.Smad 2 and Smad 3play different roles in rat hepatic stellate cell function andal-pha-smooth muscle actin organization[J] .Molecular andCellular Biochemistry,2005,16(9):4214-4224 .[24] Argentou N,Germanidis G,Hytiroglou P,et al.TGF- βsigna-ling is activated in patients with chronic HBVinfection and repressed by SMAD7 over expression aftersuccessful antiviral treatment[J].Inflammtion Research,2016,65(5):355-365.[25] Balta C,Herman H,Boldura OM,et al.Chrysin attenuatesliver fibrosis and hepatic stellate cell activation throughTGF-β/Smad signling pathway [J].Chemic BiologicalInteractions,2015,240:94-101 .[26] Marie-jose,Goumans S K,Steven Dooley P T J,et al.Inhibition of TGF-β type 1 receptor activity facilitaes liverregeneration upon acute CCl4 intoxication in mice [J].Archives of Toxicology,2016,90:347-357 .[27] Zhang S,Wang W D,Yan L,et al.Nicousamide attenuatesrenal dysfunction and glomerular injury in remnant kidneysby inhibiting TGF-β1 internalisation and renin activity[J].European Journal of Pharmacology,2018,845(15):74-84.[28] Dai G L,Sun B T,Gong T,et al.Ginsenoside Rb2 inhibitsepithelial-mesenchymal transition of colorectal cancer cellsby suppressing TGF-β/Smad signaling[J].Phytomedicine,2019,56(15):126-135.[29] 罗寅亮.六味地黄汤对 5/6 肾切除大鼠 TGF-β1、Smad2/3及 Smad7 表达的影响[C].中国中西医结合学会肾脏疾病专业委员会 2018 年学术年会论文摘要汇编中国中西医结合学会肾脏疾病专业委员会,2018.

相似文献/References:

[1]唐梦华,吴玉强.治疗肝纤维化瑶药复方黄根方的研究进展[J].大众科技,2019,21(09):63.
　Research Progress of Cmpound HuangGen of Guangxi Yao Medicine in theTreatment of Hepatic Fibrosis[J].Popular Science & Technology,2019,21(07):63.
[2]杨寿松 张龄予 吕 超 刘辉华 陆石俊 覃武海 张荣臻.棒柄花叶清肝胶囊联合替诺福韦治疗慢性乙肝肝纤维化患者的疗效观察[J].大众科技,2022,24(06):124.
　Observation on the Curative Effect of Bangbing Huaye Qinggan Capsule Combined with Tenofovir in the Treatment of Chronic Hepatitis B Patients with Liver Fibrosis[J].Popular Science & Technology,2022,24(07):124.
[3]黎 妍 罗伟生.中医药防治肝纤维化的研究进展[J].大众科技,2018,20(09):52.
　Research Progress on Prevention and Treatment of Liver Fibrosis with Traditional Chinese Medicine[J].Popular Science & Technology,2018,20(07):52.
[4]王玉婷 梁诗雨 谢宇娟 李舒展 徐 怡 王佳慧 赵铁建 郑 洋.基于网络药理学研究扶正化瘀方抗肝纤维分子机制[J].大众科技,2022,24(08):59.
　Study on the Molecular Mechanism of Fuzheng Huayu Prescription Against Liver Fiber Based on Network Pharmacology[J].Popular Science & Technology,2022,24(07):59.
[5]吕建林 冉思邈 胡振斌 毛德文.海珠益肝化纤方治疗肝纤维化的临床疗效观察[J].大众科技,2018,20(11):29.
　The Clinical Observation of Haizhu Yigan Huaxian Docoction on Treating Liver Fibrosis[J].Popular Science & Technology,2018,20(07):29.
[6]唐 盼 李 媛.中药单药与细胞自噬关系影响肝纤维化研究[J].大众科技,2019,21(02):82.
　Study on the Effect of Chinese Medicine on Hepatic Fibrosis[J].Popular Science & Technology,2019,21(07):82.
[7]江家鹏,黄菊芳,张扬武.熊果酸抑制肝纤维化的研究进展[J].大众科技,2020,22(05):33.
　Research Progress of Ursolic Acid in Inhibiting Against Liver Fibrosis[J].Popular Science & Technology,2020,22(07):33.
[8]张艳培 梁 健 邓 鑫 梁明坤 张冰冰 徐粤娟.浅析肝纤维化发生机制[J].大众科技,2021,23(2):40.
[9]王梓塨 邱 华 朱玟霜 李 旺 蒙荫杰 王倩倩.细胞外囊泡在肝纤维化进展中的作用机制及临床意义[J].大众科技,2022,24(12):61.
　Mechanism and Clinical Significance of Extracellular Vesicles in the Progression of Hepatic Fibrosis[J].Popular Science & Technology,2022,24(07):61.
[10]郑博文 郑 洋 郭新华 梁馨云 吴日舟 任秋怡 赵铁建.外泌体调控肝纤维化的研究进展[J].大众科技,2022,24(11):68.
　Research Progress in the Regulation of Liver Fibrosis by Exosomes[J].Popular Science & Technology,2022,24(07):68.

备注/Memo

备注/Memo:
【收稿日期】2019-05-09【基金项目】广西中医药大学研究生科研创新一般项目课题（YJSP201701）。【作者简介】刘露露 (1990－)，女（壮族），广西南宁人，广西中医药大学硕士研究生。【通信作者】赵铁建 (1957－)，男，广西南宁人，广西中医药大学基础医学院，教授。
更新日期/Last Update: 2020-01-22