[1]林少梅 林适峰 沈云珠 黄 刚 陈婉琼.基于网络药理学的甘草酸二铵治疗流感机制研究[J].大众科技,2022,24(08):102-107.
　Study on the Mechanism of Diammonium Glycyrrhizinate in the Treatment of Influenza Based on Network Pharmacology[J].Popular Science & Technology,2022,24(08):102-107.
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基于网络药理学的甘草酸二铵 治疗流感机制研究()
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《大众科技》[ISSN:1008-1151/CN:45-1235/N]

卷:
24
期数:
2022年08
页码:
102-107
栏目:
医药与卫生
出版日期:
2022-08-20

文章信息/Info

Title:
Study on the Mechanism of Diammonium Glycyrrhizinate in the Treatment of Influenza Based on Network Pharmacology
作者:
林少梅1 林适峰2 沈云珠3 黄 刚1 陈婉琼1　
（1.泉州医学高等专科学校，福建 泉州 362100； 2.泉州市中医联合医院，福建 泉州 362100； 3.福建医科大学附属第二医院，福建 泉州 362100）
关键词:
网络药理学; 甘草酸二铵; 流感
Keywords:
network pharmacology diammonium glycyrrhizinate influenza
文献标志码:
A
摘要:
目的：甘草酸二铵是临床常用的甘草酸制剂，研究从网络药理学的角度探讨甘草酸二铵治疗流感的潜在靶点和作用机制。方法：首先应用PubChem和STRING数据库获取甘草酸二铵标准靶点，接着在Genecards 数据库检索流感靶点并经Uniprot数据库校正，二者通过Venny在线工具相映射获得交集靶点，交集靶点运用STRING、Cytoscape3.7.2软件构建并分析网络拓扑参数，进一步运用R语言和DAVID平台对作用靶点进行GO功能和KEGG通路富集分析。结果：获得甘草酸二铵治疗流感的靶点23个，显著GO生物学过程115条和KEGG信号通路56条，主要涉及炎症、免疫和病毒细菌感染等。结论：甘草酸二铵可能通过多个通路作用于TNF、IL6等靶点治疗流感。
Abstract:
Objective: Diammonium glycyrrhizinate is a commonly used glycyrrhizic acid preparation in clinic. In this study, the potential target and mechanism of diammonium glycyrrhizinate in the treatment of influenza were discussed from the perspective of network pharmacology. Methods: First, PubChem and STRING databases were used to obtain the standard target of diammonium glycyrrhizinate, and then the influenza target was retrieved in genecards database and calibrated by Uniprot database. The two were mapped by Venny online tools to obtain the intersection target. The intersection targets were constructed and analyzed by using STRING and Cytoscape3.7.2 software, and further analyzed by R language and DAVID platform for GO function and KEGG pathway enrichment of the target. Results: 23 targets of diammonium glycyrrhizinate for the treatment of influenza were obtained, including 115 significant GO biological processes and 56 KEGG signaling pathways, mainly involving inflammation, immunity and viral bacterial infection. Conclusion: Diammonium glycyrrhizinate may act on TNF, IL6 and other targets in the treatment of influenza through multiple pathways.

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备注/Memo

备注/Memo:
【收稿日期】2022-05-21 【作者简介】林少梅（1990－），女，泉州医学高等专科学校助教，研究方向为药理学。 【通信作者】林适峰（1987－），男，泉州市中医联合医院主治医师，硕士，研究方向为肾脏病学相关。
更新日期/Last Update: 2022-09-19