[1]吕林艳 刘 洋 方彬又 郑志远 梁云飞 麦志雄.山牡荆不同部位提取物药效学评价研究[J].大众科技,2023,25(7):56-59.
　Study on Pharmacodynamic Evaluation of Extracts from Different Parts of Vitex Quinata (Lour.) Will[J].Popular Science & Technology,2023,25(7):56-59.
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山牡荆不同部位提取物药效学评价研究()
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《大众科技》[ISSN:1008-1151/CN:45-1235/N]

卷:
25
期数:
2023年7
页码:
56-59
栏目:
轻工与化工
出版日期:
2023-07-20

文章信息/Info

Title:
Study on Pharmacodynamic Evaluation of Extracts from Different Parts of Vitex Quinata (Lour.) Will
作者:
吕林艳1; 2 刘 洋1; 2 方彬又1; 2 郑志远1; 2 梁云飞1; 2 麦志雄1; 2
（1.广西梧州制药（集团）股份有限公司，广西 梧州 543000；2.广西天然药物现代制剂技术工程研究中心，广西 梧州 543000）
关键词:
山牡荆; 提取物; 斑马鱼; 细菌性炎症; 肾保护
Keywords:
Vitex quinata (Lour.) Will ;  extract;  zebrafish;  bacterial inflammation;  renal protection
文献标志码:
A
摘要:
目的：评价山牡荆不同部位提取物的抗细菌性炎症及肾保护的作用。方法：以受精后3天的斑马鱼用于山牡荆样品抗细菌性炎症功效最大检测浓度测定及其功效评价；以受精后2天的斑马鱼用于肾保护功效最大检测浓度测定及其功效评价。结果：山牡荆枝叶、山牡荆果实和山牡荆根和心材对模型斑马鱼的MTC均为2000 μg/mL；山牡荆枝叶1000、2000 ?g/mL浓度组，山牡荆果实1000 ?g/mL浓度组，山牡荆根和心材500、1000、2000 ?g/mL浓度组炎症部位的中性粒细胞数量较模型对照组减少，具有统计学差异。山牡荆枝叶、山牡荆果实和山牡荆根和心材的500、1000、2000 μg/mL浓度组中肾性水肿数量较模型对照组显著减少，具有统计学差异。结论：山牡荆枝叶、山牡荆果实和山牡荆根和心材均具有抗细菌性炎症、肾保护功效。
Abstract:
Objective: To evaluate the anti-bacterial inflammatory and renal protective effects of extracts from different parts of Vitex quinata (Lour.) Will. Methods: Using zebrafish from 3 days after fertilization to determine the maximum detection concentration of anti-bacterial inflammation efficacy in Vitex quinata (Lour.) Will samples and evaluate its efficacy; the maximum concentration of renal protection was measured in zebrafish 2 days after fertilization and its efficacy was evaluated. Results: The MTC of branches and leaves, fruits, roots and heartwood of Vitex quinata (Lour.) Will to model zebrafish were 2000 μg/mL. Compared with the model control group, the number of neutrophils in the inflammatory sites of Vitex quinata (Lour.) Will was reduced in 1000 and 2000 ?g/mL concentration groups in the branches and leaves of Vitex quinata (Lour.) Will, 1000 ?g/mL concentration groups in the fruits of Vitex quinata (Lour.) Will, 500, 1000 and 2000 ?g/mL concentration groups in the roots and heartwood of Vitex quinata (Lour.) Will, with statistical difference. The number of renal edema in the 500, 1000, 2000 μg/mL concentration groups of branches and leaves, fruits, roots and heartwood of Vitex quinata (Lour.) Will was significantly decreased compared with the model control group, with statistical difference. Conclusion: The branches and leaves, fruits, roots and heartwood of Vitex quinata (Lour.) Will have the effects of anti-bacterial inflammation and renal protection.

参考文献/References:

[1]　广西壮族自治区食品药品监督管理局. 广西壮族自治区瑶药材质量标准(第一卷)[M]. 南宁: 广西科学技术出版社，2014.[2] 王飞娟，景鹏，王燕，等. 山牡荆提取物对大鼠慢性肾炎模型的药效学实验研究[J]. 中医药导报，2017，23(8): 28-30.[3] 周俊怡，周严严，边宝林，等. LPS诱导斑马鱼炎症实热模型构建及脂质生物标志物筛选研究[J]. 浙江中医药大学学报，2018，42(10): 782-789.[4] KO E Y, HEO S J, CHO S H, et al. 3-Bromo-5-(ethoxymethyl)-1, 2-benzenediol inhibits LPS-induced pro-inflammatory responses by preventing ROS production and downregulating NF-κB in vitro and in a zebrafish model[J]. International Immunopharmacology, 2019, 67: 98-105.[5] 王雪，刘可春，王希敏，等. 大黄酸对马兜铃A引起的斑马鱼肾脏损伤的保护作用[J]. 中国药理学通报，2016，32(3): 361-365.[6] WANG X, GIUSTI A, NY A, et al. Nephrotoxic effects in zebrafish after prolonged exposure to aristolochic acid[J]. Toxins, 2020, 12(4): 217. [7] DING Y J, CHEN Y H. Developmental nephrotoxicity of aristolochic acid in a zebrafish model[J]. Toxicology and Applied Pharmacology, 2012, 261(1): 59-65.

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备注/Memo

备注/Memo:
【收稿日期】2023-01-09【作者简介】吕林艳（1981－），女，广西梧州制药（集团）股份有限公司高级工程师，从事药理研究和临床研究工作。【通信作者】麦志雄（1977－），男，广西梧州制药（集团）股份有限公司高级工程师，从事中药、民族药药效学研究及安全性评价工作。
更新日期/Last Update: 2023-08-16