[1]刘道忠 张宗星 江 露 袁 林 冯 佳.基于网络药理学和分子对接探讨五子衍宗丸对骨质疏松的作用机制[J].大众科技,2023,25(3):147-151.
 Mechanism of Wuziyanzong Pills on Osteoporosis Based on Network Pharmacology and Molecular Docking[J].Popular Science & Technology,2023,25(3):147-151.
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基于网络药理学和分子对接探讨五子衍宗丸对骨质疏松的作用机制()
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《大众科技》[ISSN:1008-1151/CN:45-1235/N]

卷:
25
期数:
2023年3
页码:
147-151
栏目:
医药与卫生
出版日期:
2023-03-20

文章信息/Info

Title:
Mechanism of Wuziyanzong Pills on Osteoporosis Based on Network Pharmacology and Molecular Docking
作者:
刘道忠12 张宗星12 江 露12 袁 林2 冯 佳2 
(1.湖北民族大学,湖北 恩施 445000;2.湖北民族大学风湿性疾病发生与干预湖北省重点实验室,湖北 恩施 445000)
关键词:
五子衍宗丸骨质疏松网络药理学分子对接
Keywords:
Wuziyanzong pills osteoporosis network pharmacology molecular docking
文献标志码:
A
摘要:
目的:运用网络药理学和分子对接技术探讨五子衍宗丸对骨质疏松(Osteoporosisi,OP)的作用机制。方法:对五子衍宗丸的有效成分进行多个数据库及文献检索,确定对应靶点,从多个数据库中检索骨质疏松靶点,并构建蛋白互作网络图,通过可视化软件Cytoscape构建化合物-靶点图,分析五子衍宗丸治疗骨质疏松的机制,并运用分子对接进行验证。结果:筛选到五子衍宗丸对应靶点有470个,五子衍宗丸与骨质疏松共有靶点29个,富集到179个与骨质疏松相关的信号通路,其中糖尿病并发症中的AGE-RAGE信号通路、MAPK信号通路、雌激素信号通路、JAK-STAT信号通路等富集显著。分子对接结果显示对接结果稳定。结论:五子衍宗丸活性成分可能通过调节激素水平、抗炎、改善骨代谢等药理作用在骨质疏松症中发挥作用。
Abstract:
Objective: To explore the mechanism of Wuziyanzong pills on osteoporosis (OP) by using network pharmacology and molecular docking technology. Methods: The active ingredients of Wuziyanzong pills were searched from multiple databases and literatures to determine the corresponding targets. The osteoporosis targets were retrieved from multiple databases, and the protein interaction network diagram was constructed. The compound-target diagram was constructed through the visualization software Cytascape, and the mechanism of Wuziyanzong pills in treating osteoporosis was analyzed, and verified by molecular docking. Results: There were 470 targets corresponding to Wuziyanzong pills, 29 targets shared by Wuziyanzong pills and osteoporosis, and 179 signaling pathways related to osteoporosis were enriched, among which AGE-RAGE signal in diabetic complications pathway, MAPK signaling pathway, estrogen signaling pathway, and JAK-STAT signaling pathway were significantly enriched. Molecular docking results showed that the docking results were stable. Conclusion: The active components of Wuziyanzong pills may play a role in osteoporosis by regulating hormone levels, anti-inflammatory, improving bone metabolism and other pharmacological effects.

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备注/Memo

备注/Memo:
【收稿日期】2022-07-25【作者简介】刘道忠(1996-),男,湖南邵阳人,湖北民族大学在读硕士研究生,研究方向为中医内科学。【通信作者】袁林,男,湖北民族大学风湿性疾病发生与干预湖北省重点实验室副教授,博士,研究方向为抗风湿病中草药研究。
更新日期/Last Update: 2023-05-31