[1]刘良肇,刘?晗,张?艳,等.缺氧诱导因子-1α影响细胞自噬的研究进展[J].大众科技,2023,25(2):117-120.
　Research Progress on the Effect of Hypoxia-Inducible Factor-1α on Autophagy[J].Popular Science & Technology,2023,25(2):117-120.
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缺氧诱导因子-1α影响细胞自噬的研究进展()
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《大众科技》[ISSN:1008-1151/CN:45-1235/N]

卷:
25
期数:
2023年2
页码:
117-120
栏目:
医药与卫生
出版日期:
2023-02-20

文章信息/Info

Title:
Research Progress on the Effect of Hypoxia-Inducible Factor-1α on Autophagy
作者:
刘良肇1; 2 ;  刘?晗1; 2; ?张?艳1; 2 ;  莫林烽3; ?王　娜４; 何永华1; 2
（1.桂林医学院公共卫生学院，广西 桂林 541001；
2.广西环境暴露组学与全生命周期健康重点实验室，广西 桂林 541199；
3.广州华商职业学院健康医学院，广东 广州 511300；
４．内蒙古呼伦贝尔市传染病医院，内蒙古 呼伦贝尔 162650）
关键词:
HIF-1α; 氧稳态; 细胞自噬
Keywords:
HIF-1α;  oxygen homeostasis;  autophagy
文献标志码:
A
摘要:
缺氧诱导因子（hypoxia-inducible factor，HIF）是氧稳态中最关键的因子之一。HIF-1α是HIF的主要调节因子，是机体多种病理反应中的重要因子。自噬（autophagy，II 型程序性细胞死亡）可以通过多种方式影响细胞代谢。HIF-1α可以通过调节氧代谢与线粒体功能、PI3K／Akt／mTOR等多种途径影响细胞自噬的过程，文章综述了HIF-1α影响细胞自噬的研究进展，为探究相关疾病机制提供参考。
Abstract:
Hypoxia-inducible factor (HIF) is one of the most critical factors in oxygen homeostasis. HIF-1α is the main regulatory factor of HIF and an important factor in a variety of pathological reactions. Autophagy (autophagy, type II programmed cell death) can affect cell metabolism in many ways. HIF-1α can affect the process of autophagy by regulating oxygen metabolism and mitochondrial function, PI3K/Akt/mTOR and other pathways. This paper reviews the research progress of HIF-1α effect on autophagy and provides reference for exploring the mechanism of related diseases.

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备注/Memo

备注/Memo:
【收稿日期】2022-08-19
【基金项目】广西自然科学基金项目（2020GXNSFDA297028）；广西硕士研究生创新项目（YCSW2021245）。
【作者简介】刘良肇（1997－），男，江西鹰潭人，桂林医学院公共卫生学院在读硕士研究生，研究方向为流行病与卫生统计学。

更新日期/Last Update: 2023-04-27