[1]林 芃.复方丹参滴丸对老年颈动脉粥样硬化患者金属蛋白酶的影响[J].大众科技,2022,24(08):64-67.
　Effect of Compound Danshen Dripping Pills on Metalloproteinases in Elderly Patients with Carotid Atherosclerosis[J].Popular Science & Technology,2022,24(08):64-67.
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复方丹参滴丸对老年颈动脉粥样硬化患者 金属蛋白酶的影响()
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《大众科技》[ISSN:1008-1151/CN:45-1235/N]

卷:
24
期数:
2022年08
页码:
64-67
栏目:
医药与卫生
出版日期:
2022-08-20

文章信息/Info

Title:
Effect of Compound Danshen Dripping Pills on Metalloproteinases in Elderly Patients with Carotid Atherosclerosis
作者:
林 芃　
（广西医科大学第一附属医院，广西 南宁 530022）
关键词:
复方丹参滴丸; 老年; 颈动脉粥样硬化; 金属蛋白酶; 细胞黏附分子
Keywords:
compound Danshen dripping pills senility carotid atherosclerosis metalloproteinases cell adhesion molecule
文献标志码:
A
摘要:
目的：分析复方丹参滴丸对老年颈动脉粥样硬化患者金属蛋白酶的影响。方法：选择广西医科大学第一附属医院老年病学门诊接诊的63例老年颈动脉粥样硬化患者作为研究主体，接诊过程中，以随机数字表法对患者进行分组，28例分到对照组，35例分到研究组，对照组采用常规西医治疗，研究组在常规西医治疗的基础上增加复方丹参滴丸治疗，对比两组患者治疗前后的可溶性血管细胞黏附分子1（SVCAM-1）、可溶性细胞间黏附分子（SLCAM-1）等细胞黏附分子水平、血小板最大聚集率（PAGM）、基质金属蛋白酶-2（MMP2）、基质金属蛋白酶-9（MMP9）等金属蛋白酶水平、治疗期间的不良反应发生率及治疗总有效率。结果：治疗前，两组患者SVCAM-1、SLCAM-1等细胞黏附分子水平、PAGM、MMP2、MMP9等金属蛋白酶水平对比均无显著差异（P＞0.05），治疗6个月后，研究组患者SVCAM-1、SLCAM-1等细胞黏附分子水平、PAGM、MMP2、MMP9等金属蛋白酶水平均显著低于对照组，研究组患者治疗总有效率显著高于对照组，两组对比具有统计学意义（P＜0.05）；研究组患者治疗期间的不良反应发生率略低于对照组，两组间对比无统计学意义（P＞0.05）。结论：复方丹参滴丸治疗老年颈动脉粥样硬化的效果显著，不仅能有效改善细胞黏附分子、金属蛋白酶水平及血小板最大聚集率，还能提升其治疗效果，且产生的毒副作用较少，因此，其是一种安全高效的治疗方案，值得临床应用和推广。
Abstract:
Objective: To analyze the effect of compound Danshen dripping pills on metalloproteinases in elderly patients with carotid atherosclerosis. Methods: 63 elderly patients with carotid atherosclerosis admitted to the geriatric outpatient department of the First Affiliated Hospital of Guangxi Medical University were selected as the research subjects. During the admission process, the patients were divided into groups by random number table method, 28 cases were assigned to the control group, and 35 cases were assigned to the control group. The control group was treated with conventional western medicine, and the study group was treated with compound Danshen dripping pills on the basis of conventional western medicine. The levels of soluble vascular cell adhesion molecule-1 (SVCAM-1), soluble intercellular adhesion molecule (SLCAM-1) and other cell adhesion molecules, the levels of platelet maximum aggregation rate (PAGM), matrix metalloproteinase-2 (MMP2), matrix metalloproteinase-9 (MMP9) and other metalloproteinases, the incidence of adverse reactions and the total effective rate were compared between the two groups before and after treatment. Results: Before treatment, there was no significant difference in the levels of cell adhesion molecules such as SVCAM-1, SLCAM-1, and metalloproteinases such as pagm, MMP2, and MMP9 between the two groups (P>0.05). After 6 months of treatment, the levels of cell adhesion molecules such as SVCAM-1, SLCAM-1, and metalloproteinases such as pagm, MMP2, and MMP9 in the study group were significantly lower than those in the control group. The total effective rate of the study group was significantly higher than that in the control group. The comparison between the two groups was statistically significant (P＜0.05) The incidence of adverse reactions in the study group was slightly lower than that in the control group, and there was no significant difference between the two groups (P>0.05). Conclusion: The effect of compound Danshen dripping pills in the treatment of carotid atherosclerosis in the elderly is significant. It can not only effectively improve the level of cell adhesion molecules, metalloproteinases and the maximum aggregation rate of platelets, but also improve its therapeutic effect, and produce less toxic and side effects. Therefore, it is a safe and efficient treatment scheme, which is worthy of clinical application and promotion.

参考文献/References:

[1] 马惠，常国栋，刘倩. 心脉通胶囊治疗冠心病合并颈动脉粥样硬化疗效及对基质金属蛋白酶的影响[J]. 中国循证心血管医学杂志，2021，13(9): 1112-1114. [2] 王俊奇，顿驭光. 复方丹参滴丸联合阿托伐他汀治疗对伴有颈动脉粥样硬化短暂性脑缺血发作患者脑循环动力的影响[J]. 广州医药，2021，52(1): 105-108，119. [3] 曹端华，王婷婷，闫海燕，等. 复方丹参滴丸联合阿托伐他汀治疗颈动脉粥样硬化的疗效研究[J]. 中国全科医学，2019，22(27): 3323-3327. [4] 罗华，吕海阳. 复方丹参滴丸对老年颈动脉粥样硬化患者细胞黏附分子、内皮素及血小板聚集率的影响[J]. 海南医学院学报，2019，25(17): 1332-1336. [5] 贾红停. 复方丹参滴丸联合阿托伐他汀钙治疗2型糖尿病合并颈动脉硬化的疗效分析[J]. 黑龙江医药，2019，32(2): 359-360. [6] 史丽，李明霞，王立坤，等. 复方丹参滴丸联合阿托伐他汀钙治疗2型糖尿病合并颈动脉硬化的临床疗效及安全性评价[J]. 中国临床药理学杂志，2016，32(6): 489-491.

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备注/Memo

备注/Memo:
【收稿日期】2022-06-20 【基金项目】广西壮族自治区中医药管理局项目（G22c2020182）。 【作者简介】林芃（1963－），广西南宁人，广西医科大学第一附属医院副主任医师，研究方向为老年内科学。
更新日期/Last Update: 2022-09-19