[1]何晓翠 周卓宁.基于网络药理学探讨当归芍药散治疗糖尿病肾病的作用机制[J].大众科技,2022,24(03):72-77.
　Study on the Mechanism of Danggui Shaoyao Powder in the Treatment of Diabetic Kidney Disease Based on Network Pharmacology[J].Popular Science & Technology,2022,24(03):72-77.
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基于网络药理学探讨当归芍药散治疗糖尿病 肾病的作用机制()
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《大众科技》[ISSN:1008-1151/CN:45-1235/N]

卷:
24
期数:
2022年03
页码:
72-77
栏目:
医药与卫生
出版日期:
2022-03-20

文章信息/Info

Title:
Study on the Mechanism of Danggui Shaoyao Powder in the Treatment of Diabetic Kidney Disease Based on Network Pharmacology
作者:
何晓翠1 周卓宁2　
（1.广西中医药大学，广西 南宁 530000；2.广西中医药大学附属瑞康医院，广西 南宁 530000）
关键词:
网络药理学; 当归芍药散; 糖尿病肾病; 靶点预测
Keywords:
network pharmacology Danggui Shaoyao powder diabetic kidney disease target prediction
文献标志码:
A
摘要:
目的：通过网络药理学方法探讨当归芍药散治疗糖尿病肾病（DKD）的机制。方法：使用TCMSP数据库检索当归芍药散的活性成分，并利用PubChem数据库与Swiss Target Prediction平台收集当归芍药散6味中药活性成分的作用靶点；通过OMIM、DrugBank、TTD、GeneCards数据库获取糖尿病肾病的靶点；使用STRING平台构建PPI网络图；基于Cytoscape3.7.0软件，构建当归芍药散-活性成分-DKD作用靶点网络图；运用DAVID 6.8数据库对当归芍药散-DKD共同靶点进行GO功能与KEGG通路富集分析。结果：筛选出当归芍药散治疗DKD的活性成分共20个，关键靶点361个，生物过程共694条，信号通路共128条。结论：当归芍药散通过多种成分、多靶点、多途径、多种通路发挥其对糖尿病肾病的治疗作用。
Abstract:
Objective: To explore the mechanism of Danggui Shaoyao Powder in the treatment of diabetic kidney disease (DKD) through network pharmacology. Methods: TCMSP database was used to search the active components of Danggui Shaoyao powder, and the action targets of 6 active components of Danggui Shaoyao powder were collected by PubChem database and Swiss Target Prediction platform the targets of diabetic kidney disease were obtained through OMIM, DrugBank, TTD and GeneCards databases. Use STRING platform to build PPI network diagram based on Cytoscape 3.7.0 software to construct the target network diagram of Danggui Shaoyao powder-active ingredient-DKD David 6.8 database was used to analyze the go function and KEGG pathway enrichment of the common target of Danggui Shaoyao powder-DKD. Results: A total of 20 active components, 361 key targets, 694 biological processes, and 128 signal pathways of Danggui Shaoyao powder in the treatment of DKD were screened. Conclusion: Danggui Shaoyao powder can play a role in the treatment of diabetic kidney disease through multiple components, multiple targets, multiple channels and multiple pathways.

参考文献/References:

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备注/Memo

备注/Memo:
【收稿日期】2022-01-14 【基金项目】广西中医药管理局项目（GZBZ21-5）；广西卫健委重点课题（S201419_07）。 【作者简介】何晓翠（1996－），女，广西中医药大学在读硕士研究生，研究方向为内分泌代谢性疾病的临床治疗与研究。 【通信作者】周卓宁（1968－），女，广西中医药大学附属瑞康医院主任医师，教授，硕士研究生导师，研究方向为内分泌代谢性疾病的临床治疗与研究。
更新日期/Last Update: 2022-06-21