[1]廖煜雄　何乾超　高玉广　刘琦琦　莫穷泽.中药单体化合物治疗癫痫的实验研究进展[J].大众科技,2021,23(11):75-79.
　Experimental Research Progress of Traditional Chinese Medicine Monomer Compounds in the Treatment of Epilepsy[J].Popular Science & Technology,2021,23(11):75-79.
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中药单体化合物治疗癫痫的实验研究进展()
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《大众科技》[ISSN:1008-1151/CN:45-1235/N]

卷:
23
期数:
2021年11
页码:
75-79
栏目:
医药与卫生
出版日期:
2021-11-20

文章信息/Info

Title:
Experimental Research Progress of Traditional Chinese Medicine Monomer Compounds in the Treatment of Epilepsy
作者:
廖煜雄1　何乾超2　高玉广2　刘琦琦1　莫穷泽1　
（1.广西中医药大学，广西 南宁 530000；2.广西中医药大学第一附属医院，广西 南宁 530023）
关键词:
中药; 单体化合物; 癫痫
Keywords:
traditional Chinese medicine monomer compounds epilepsy
文献标志码:
A
摘要:
癫痫的基本病理特征为脑部神经元过度放电所致的突然、反复和短暂的中枢神经系统功能失常。大量实验研究表明中药单体化合物在治疗癫痫方面取得不错成绩，文章选取近年来研究次数较为频繁的几味中药，如人参、全蝎、大黄、天麻等中药单体化合物，从调控离子通道、抗氧化应激、保护神经元细胞、抑制神经元细胞凋亡、抑制炎症因子等方面综述国内外期刊报道的中药单体化合物抗癫痫作用机制的实验研究进展，为癫痫的新药研发提实验依据。
Abstract:
The basic pathological characteristics of epilepsy are sudden, repeated and transient dysfunction of the central nervous system caused by excessive discharge of brain neurons. A large number of experimental studies show that traditional Chinese medicine monomer compounds have made good achievements in the treatment of epilepsy. This paper selects several traditional Chinese medicine monomer compounds that have been studied frequently in recent years, such as ginseng, scorpion, rhubarb, gastrodia elata and so on, from the aspects of regulating ion channels, antioxidant stress, protecting neuronal cells, inhibiting neuronal cell apoptosis, this paper reviews the experimental research progress on the anti epileptic mechanism of traditional Chinese medicine monomer compounds reported in domestic and foreign journals, so as to provide experimental basis for the development of new drugs for epilepsy.

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备注/Memo

备注/Memo:
【收稿日期】2021-09-25 【基金项目】广西自然科学基金面上项目（2019JJA140204）；2020年广西高等学校高水平创新团队及卓越学者计划（桂教人才〔2020〕6号）；广西中医药大学“岐黄工程”高层次人才团队培育项目（2018003）；广西中医药大学第一附属医院学术团队建设项目（院字〔2018〕146号）；广西中医脑病临床研究中心。 【作者简介】廖煜雄，男，广西中医药大学在读硕士研究生，研究方向为脑血管及心身疾病中西医结合治疗。 【通信作者】何乾超，男，广西中医药大学第一附属医院主任医师，教授，硕士研究生导师，研究方向为脑血管及心身疾病中西医结合治疗。
更新日期/Last Update: 2022-02-14