[1]梁小丹 蒙秋鸿.复方丹参注射液联合硫酸镁治疗子痫前期的疗效及对血清PLGF、sFlt-1、sEng的影响[J].大众科技,2021,23(9):56-59.
　Efficacy of Compound Salvia Miltiorrhiza Injection Combined with Magnesium Sulfate in the Treatment of Preeclampsia and Its Effect on Serum PLGF, sFlt-1 and sEng[J].Popular Science & Technology,2021,23(9):56-59.
点击复制

复方丹参注射液联合硫酸镁治疗子痫前期的 疗效及对血清PLGF、sFlt-1、sEng的影响()
分享到：

《大众科技》[ISSN:1008-1151/CN:45-1235/N]

卷:
23
期数:
2021年9
页码:
56-59
栏目:
医药与卫生
出版日期:
2021-09-20

文章信息/Info

Title:
Efficacy of Compound Salvia Miltiorrhiza Injection Combined with Magnesium Sulfate in the Treatment of Preeclampsia and Its Effect on Serum PLGF, sFlt-1 and sEng
作者:
梁小丹 蒙秋鸿
（灵山县中医医院，广西 钦州 535400）
关键词:
子痫前期; 复方丹参注射液; PLGF; sFlt-1; sEng
Keywords:
preeclampsia compound salvia miltiorrhiza injection PLGF sFlt-1 sEng
文献标志码:
A
摘要:
目的：观察复方丹参注射液联合硫酸镁对子痫前期（PE）的临床效果及对血清胎盘生长因子（PLGF）、可溶性血管内皮生长因子受体1（sFlt-1）、可溶性内皮因子（sEng）的影响。方法：选取120例患者随机分为对照组和研究组，每组各60例。对照组予硫酸镁注射液治疗，研究组在对照组基础上加用复方丹参注射液治疗，两组疗程均为10天。观察比较两组临床疗效、血压、24h尿蛋白、血清PLGF、sFlt-1、sEng水平、症状积分及妊娠结局变化。结果：两组疗程结束后，研究组临床总有效率（91.67%）高于对照组（75%）（P<0.05）；治疗后，研究组血压及24h尿蛋白相比对照组降低更显著（P<0.05）；治疗后，研究组血清PIGF水平相比对照组明显上调（P<0.05）；治疗后，研究组血清sFlt-1、sEng水平较对照组下调幅度更大（P<0.05）；治疗后，两组症状均有所缓解，但研究组缓解程度大于对照组（P<0.05）；治疗后，研究组子痫发生率、产后出血率明显减少，且1 min Apgar评分明显升高，较对照组疗效更优（P<0.05）。结论：复方丹参注射液联合硫酸镁治疗PE的疗效显著，可能与上调PLGF水平，下调sFlt-1、sEng水平，提高血管内皮功能，改善缺血缺氧状态有关。
Abstract:
Objective: To observe the clinical effect of compound salvia miltiorrhiza injection combined with magnesium sulfate on preeclampsia (PE) and its effect on serum placental growth factor (PLGF), soluble vascular endothelial growth factor receptor 1 (sFlt-1) and soluble endothelial factor (sEng). Methods: 120 patients were randomly divided into control group and study group, with 60 cases in each group. The control group was treated with magnesium sulfate injection, and the study group was treated with compound Salvia miltiorrhiza injection on the basis of the control group. The course of treatment of both groups was 10 days. The clinical efficacy, blood pressure, 24-hour urinary protein, serum levels of PLGF, sFlt-1, sEng, symptom score and pregnancy outcome were observed and compared between the two groups. Results: After treatment, the total clinical effective rate in the study group (91.67%) was higher than that in the control group (75%)(P<0.05). After treatment, the blood pressure and 24-hour urinary protein in the study group were significantly lower than those in the control group (P<0.05). After treatment, the level of serum PIGF in the study group was significantly higher than that in the control group (P<0.05). After treatment, the levels of serum sFlt-1 and sEng in the study group were significantly lower than those in the control group (P<0.05). After treatment, the symptoms of the two groups were relieved, but the degree of remission in the study group was higher than that in the control group (P<0.05). After treatment, and the incidence of eclampsia and postpartum hemorrhage in the study group decreased significantly, and the 1minApgar score increased significantly, which was better than that in the control group (P<0.05). Conclusion: Compound salvia miltiorrhiza injection combined with magnesium sulfate is effective in the treatment of PE, which may be related to the up-regulation of PLGF level, down-regulation of sFlt-1 and sEng level, improvement of vascular endothelial function and improvement of ischemia and hypoxia.

参考文献/References:

[1]　Esteve-Valverde E, Ferrer-Oliveras R, Gil-Aliberas N, et al. Pravastatin for preventing and treating preeclampsia: a systematic review[J]. Obstetrical and Gynecological Survey, 2018, 73(1): 40-55. [2] 漆洪波，童超. 从母胎界面着眼探究子痫前期的发病机制[J]. 中国实用妇科与产科杂志，2020，36(1): 61-64. [3] 王正平，薛梦玲，王玉慧. 血管因子与子痫前期研究进展[J]. 浙江医学，2019，41(21): 2251-2255，2264. [4] Staff A C. Long-term cardiovascular health after stopping pre-eclampsia[J]. Lancet, 2019, 394(10204): 1120-1121. [5] 廖政邦. 复方丹参注射液在临床中的药理应用研究[J]. 中国医药指南，2014，12(15): 296-297. [6] 杨孜，张为远. 妊娠期高血压疾病诊治指南(2015)[J]. 中华围产医学杂志，2016，19(3): 161-169. [7] 郑筱萸. 中药新药临床研究指导原则[M]. 北京: 中国医药科技出版社，2002. [8] 张玲. 硫酸镁对子痫前期孕妇及胎儿动脉血流的影响[J]. 重庆医学，2017，46(18): 2512-2514. [9] 焦素芬，孙绍静，班小娟，等. 复方丹参注射液联合硫酸镁对子痫前期患者胎盘循环的影响[J]. 中国药业，2021，30(5): 45-47. [10] Jim B, Karumanchi S A. Preeclampsia: pathogenesis, prevention, and long-term complications[J]. Seminars in Nephrology, 2017, 37(4): 386-397. [11] 童婷婷，虞晴，尤子善. 等子痫前期孕妇血浆蛋白酶Corin、PLGF、sEng、sFlt-1水平变化及临床意义[J]. 中国妇产科临床杂志，2021，22(3): 285-286. [12] 郭莉，田小娟，杨志伟. 硫酸镁联合硝苯地平对子痫前期患者血清同型半胱氨酸、胎盘生长因子及妊娠的影响[J]. 宁夏医科大学学报，2018，40(8): 919-923. [13] Thompson L P, Pence L, Pinkas G, et al. Placental hypoxia during early pregnancy causes maternal hypertension and placental insufficiency in the hypoxic guinea pig model[J]. Biology of Reproduction, 2016, 95(6): 1-10. [14] 李姣，邱冉冉. 复方丹参注射液对早发型子痫前期IGF-1、PLGF水平及妊娠危重结局的影响研究[J]. 中华中医药学刊，2020，38(11): 251-254. [15] 李可，朱大伟，陈建昆，等. 子痫前期发病机制与临床治疗研究进展[J]. 解放军医学杂志，2019，44(5): 423-429. [16] 张展，宋婉玉，张琳琳，等. 血管生成因子、抗血管生成因子表达变化在子痫前期发病中的作用机制研究进展[J]. 山东医药，2017，57(15): 112-114. [17] 屠晓君，王守燕，尚进，等. AT1-AA及SEng在子痫前期孕妇病情评估的应用价值[J]. 潍坊医学院学报，2021，43(1): 19-22. [18] 叶石玄宝，刘姣，郑芬，等. 孕妇血中胎盘生长因子、血管内皮生长因子受体-1及和肽素与子痫前期的关系[J]. 中国卫生检验杂志，2021，31(2): 203-205，209.

相似文献/References:

[1]陈桂才　邹　冰　农绍志　何桂娟　龙增勇　陈汝斌　李秋梅　黄晓萍.妊娠期高血压疾病各期病重程度对新生儿听力筛查影响的临床研究[J].大众科技,2021,23(12):51.
　Clinical Study on the Effect of Severity of Hypertension Disorders Complicating Pregnancy on Neonatal Hearing Screening[J].Popular Science & Technology,2021,23(9):51.

备注/Memo

备注/Memo:
【收稿日期】2021-05-25 【作者简介】梁小丹（1983－），女，广西灵山县人，灵山县中医医院主治医师，研究方向为产科。
更新日期/Last Update: 2022-01-26