[1]蒋腾川　招丽君　兰　星　梁云飞　邓慧芳　黎雅芝.注射用血栓通（冻干）与注射用七叶皂苷钠的配伍稳定性研究[J].大众科技,2021,23(7):25-28.
　Study on Compatibility Stability of Xueshuantong for Injection (lyophilized) andSodium Aescinate for Injection[J].Popular Science & Technology,2021,23(7):25-28.
点击复制

注射用血栓通（冻干）与注射用七叶皂苷钠的 配伍稳定性研究()
分享到：

《大众科技》[ISSN:1008-1151/CN:45-1235/N]

卷:
23
期数:
2021年7
页码:
25-28
栏目:
出版日期:
2021-07-20

文章信息/Info

Title:
Study on Compatibility Stability of Xueshuantong for Injection (lyophilized) and Sodium Aescinate for Injection
作者:
蒋腾川1　招丽君1　兰　星1　梁云飞1　邓慧芳2　黎雅芝2
（1.广西中恒创新医药研究有限公司，广西 南宁 530000； 2.广西梧州制药（集团）股份有限公司，广西 梧州 543002）
关键词:
注射用血栓通（冻干）; 注射用七叶皂苷钠; 配伍稳定性
Keywords:
Xueshuantong for Injection (lyophilized) sodium aescinate for injection compatible stability
文献标志码:
A
摘要:
目的：探讨注射用血栓通（冻干）与注射用七叶皂苷钠的配伍稳定性研究。方法：注射用血栓通（冻干）与注射用七叶皂苷钠按临床实际条件进行联合使用，采用液质联用法测定配伍溶液中七叶皂苷钠含量。并根据《中国药典》分别检测配伍后7 h内溶液渗透压、不溶性微粒、pH值、性状等各项指标变化情况，综合评价药物配伍后的稳定性。结果：注射用血栓通（冻干）与注射用七叶皂苷钠配伍后在7 h内渗透压、pH值、性状均保持稳定，不溶性微粒虽有变化，但仍在合格范围内。结论：注射用血栓通（冻干）与注射用七叶皂苷钠配伍在7 h内稳定。
Abstract:
Objective: To study the compatible stability of Xueshuantong for Injection (lyophilized) and sodium aescinate for injection. Methods: Xueshuantong for Injection (lyophilized) and sodium aescinate for injection were used in combination according to clinical conditions. The content of sodium aescinate in the compatible solution was determined by LC/MS. According to the Chinese Pharmacopoeia, the changes of solution osmotic pressure, insoluble particles, pH value, properties and other indexes within 7 hours after compatibility were detected to comprehensively evaluate the stability of drugs after compatibility. Results: The osmotic pressure, pH value and properties of Xueshuantong for injection (lyophilized) and sodium aescinate for injection remained stable within 7h. Although the insoluble particles changed, they were still within the qualified range. Conclusions: The compatibility of Xueshuantong for Injection (lyophilized) and sodium aescinate for injection was stable within 7 hours.

参考文献/References:

[1]　姚亚敏，胡薏慧，常昕楠，等. 基于医院信息系统的真实世界的注射用血栓通(冻干)临床用药特征分析[J]. 上海医药，2021，42(3): 10-14. [2]　李俊峰，刘建军. 注射用血栓通(冻干)不合理用药帕累托图分析[J]. 海峡药学，2020，32(6): 203-206. [3]　于一，王慧，刘红亮，等. 注射用七叶皂苷钠安全性风险分析及思考[J]. 中国药物警戒，2021，18(2): 174-177. [4]　Wang M, Zhang H, Dong R, et al. Compatible Stability Study of Panax Notoginseng Saponin(PNS) Injection (Xueshuantong®) in combination with 47 different injectables[J]. Biomed Chromatogr, 2016, 30(10): 1599- 1610. [5]　刘立东. 七叶皂苷主要活性成分的药代动力学研究[D].长春: 吉林大学，2012. [6]　张元萍，能英，季宏建. 486 例注射用七叶皂苷钠主动监测情况分析[J]. 中国医院用药评价与分析，2019，19(8): 985-990. [7]　李燕华，李仲昆，丁莉，等. 七叶皂苷钠致肾功能损害文献分析[J]. 临床合理用药，2020，13(6): 22-24. [8]　王奕兰. 血栓通与七叶皂苷钠联合治疗糖尿病足的临床效果[J]. 海峡药学，2018，30(8): 221-223.

相似文献/References:

[1]刘冠萍 吕林艳 罗 艳 张木兰 韦日伟.注射用血栓通（冻干）与盐酸克林霉素注射液 配伍的毒性和含量研究[J].大众科技,2018,20(11):26.
　Toxicity and Contents of Components in the Compatibility of Lyophilized Xueshuantong for Injection and Clindamycin Hydrochloride Injection[J].Popular Science & Technology,2018,20(7):26.
[2]陈苑君 童冰妮 麦志雄 冼卫清.注射用血栓通（冻干）包装系统密封性研究[J].大众科技,2023,25(9):30.
　Study on Sealability of Packaging System of Xueshuantong (Lyophilized) for Injection[J].Popular Science & Technology,2023,25(7):30.
[3]罗 艳,刘冠萍.注射用血栓通（冻干）在脑血管疾病的临床运用进展[J].大众科技,2019,21(05):78.
　Advances in the Clinical Application of Xueshuantong for Injection(Lyophilized)in Cerebrovascular Diseases[J].Popular Science & Technology,2019,21(7):78.
[4]覃济桓 张兆佳 王海燕 刘冠萍 梁云飞.气相色谱法测定注射用血栓通（冻干）中 两种成分的残留[J].大众科技,2020,22(08):45.
　Determination of Residual Amounts of Two Compounds in Xueshuantong for Injection(Lyophilized) by Gas Chromatography[J].Popular Science & Technology,2020,22(7):45.
[5]黄展文 覃济桓 王海燕 梁云飞 张兆佳.HPLC 法测定注射用血栓通（冻干）中抗氧剂 1010 的迁移含量[J].大众科技,2020,22(09):49.
　Determination of Migration Content of Antioxidant 1010 in Xueshuantong for Injection (lyophilized) by HPLC[J].Popular Science & Technology,2020,22(7):49.
[6]张兆佳 梁云飞 黄展文.HPLC法测定注射用血栓通（冻干）中可提取硫的迁移含量[J].大众科技,2021,23(4):51.
　Determination of Migration Content of Extractable Sulphur in Xueshuantong for Injection (lyophilized) by HPLC[J].Popular Science & Technology,2021,23(7):51.
[7]童冰妮.费休氏水分测定法测定注射用血栓通（冻干）的水分[J].大众科技,2021,23(10):35.

备注/Memo

备注/Memo:
【收稿日期】2021-05-06 【基金项目】广西科技基地和人才专项项目（桂科AD20297068）；广西三七综合利用技术重点实验室。 【作者简介】蒋腾川（1989－），女，供职于广西中恒创新医药研究有限公司，从事中药研究相关工作。
更新日期/Last Update: 2021-10-22