[1]李 瑛 胡振斌.活血化瘀类中药防治肝纤维化机制的研究进展[J].大众科技,2021,23(6):49-52.
 Research Progress on Mechanism of Traditional Chinese Medicine for Promoting Blood Circulation and Removing Blood Stasis in Prevention and Treatment of Liver Fibrosis[J].Popular Science & Technology,2021,23(6):49-52.
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活血化瘀类中药防治肝纤维化机制的研究进展()
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《大众科技》[ISSN:1008-1151/CN:45-1235/N]

卷:
23
期数:
2021年6
页码:
49-52
栏目:
医药与卫生
出版日期:
2021-06-20

文章信息/Info

Title:
Research Progress on Mechanism of Traditional Chinese Medicine for Promoting Blood Circulation and Removing Blood Stasis in Prevention and Treatment of Liver Fibrosis
作者:
李 瑛1 胡振斌2
(1.广西中医药大学,广西 南宁 530000;2.广西中医药大学第一附属医院,广西 南宁 530000)
关键词:
肝纤维化机制活血化瘀类中药进展
Keywords:
mechanism of liver fibrosis traditional Chinese medicine for promoting blood circulation and removing blood stasis progress
文献标志码:
A
摘要:
目的:将活血化瘀类中药对肝纤维化(Hepatic fibrosis,HF)的干预机制以及治疗作用进行归纳、概括。方法:查阅近5年来有关活血化瘀类中药防治肝纤维化的文献资料,通过分析、总结得出结论。结果:活血化瘀类中药干预肝纤维化的机制与抑制肝星状细胞(Hepatic stellate cells,HSCs)活化增殖有关,HSCs的活化增殖主要通过细胞因子及受体的表达、信号传导通路、炎症反应、氧化应激反应等实现,其能够保护和改善肝脏功能,抑制肝的纤维化。结论:活血化瘀类中药可改善肝纤维化患者的临床症状,延缓肝纤维化的发生、发展,从而起到改善肝功能、保护肝脏的作用,对提高患者的生活质量大有裨益。
Abstract:
Objective: To conclude and summarize the intervention mechanism and therapeutic effect of traditional Chinese medicine of promoting blood circulation and removing blood stasis on hepatic fibrosis (HF). Methods: The literatures about the prevention and treatment of liver fibrosis with traditional Chinese medicine of promoting blood circulation and removing blood stasis in recent 5 years were reviewed, and conclusions were drawn through analysis and summary. Results: The mechanism of raditional Chinese medicine for promoting blood circulation and removing blood stasis on liver fibrosis is related to the inhibition of the activation and proliferation of hepatic stellate cells (HSCs). The activation and proliferation of HSCs are mainly realized through the expression of cytokines and receptors, signal transduction pathway, inflammatory reaction, oxidative stress reaction, etc., which can protect and improve liver function and inhibit liver fibrosis. Conclusion: Traditional Chinese medicine of promoting blood circulation and removing blood stasis can improve clinical symptoms of patients with liver fibrosis, delay the occurrence and development of liver fibrosis, thus improving liver function and protecting the liver, which is of great benefit to improving the quality of life of patients.

参考文献/References:

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备注/Memo

备注/Memo:
【收稿日期】2021-04-05 【基金项目】国家科技重大专项课题子课题(NO.2018ZX10725505-002)。 【作者简介】李瑛(1994-),女,湖南邵阳人,广西中医药大学2019级硕士研究生,研究方向为中医药防治肝病。 【通信作者】胡振斌(1969-),男,广西中医药大学第一附属医院教授,硕士研究生导师,研究方向为中医药防治肝病。
更新日期/Last Update: 2021-09-14