[1]李 研 李 锋 李明明 钟 斌.炉甘石洗剂联合苦黄散外洗治疗葡萄球菌性烫 伤样皮肤综合征的临床研究[J].大众科技,2021,23(2):45-47.
　Clinical Study on Calamine Lotion Combined with Kuhuang Powder in the Treatment of Staphylococcal Scald Skin Syndrome[J].Popular Science & Technology,2021,23(2):45-47.
点击复制

炉甘石洗剂联合苦黄散外洗治疗葡萄球菌性烫 伤样皮肤综合征的临床研究()
分享到：

《大众科技》[ISSN:1008-1151/CN:45-1235/N]

卷:
23
期数:
2021年2
页码:
45-47
栏目:
医药与卫生
出版日期:
2021-02-20

文章信息/Info

Title:
Clinical Study on Calamine Lotion Combined with Kuhuang Powder in the Treatment of Staphylococcal Scald Skin Syndrome
作者:
李 研 李 锋 李明明 钟 斌
（梧州市中医医院，广西 梧州 543000）
关键词:
炉甘石洗剂; 苦黄散; 外洗; 联合治疗; 金葡萄球菌性烫伤样皮肤综合征; 疗效
Keywords:
calamine lotion;  Kuhuang powder;  external washing;  combined treatment;  staphylococcal scald skin syndrome;  curative effect
文献标志码:
A
摘要:
目的：探究炉甘石洗剂联合苦黄散外洗治疗葡萄球菌性烫伤样皮肤综合征（Staphylococcal scalded skin syndrome， SSSS）的临床疗效。方法：将 2016 年 6 月至 2019 年 2 月在梧州市中医医院接受治疗的 101 例 SSSS 患儿视为研究对象，以随 机数字表法分为两组，甲组仅进行常规西医治疗，乙组在甲组基础上采用炉甘石洗剂联合苦黄散外洗治疗，对比两组临床疗效、 症状改善时间、住院时间、治疗前后白细胞计数（White blood cell count，WBC）、中性粒细胞百分比（The percentage of neutrophils， N）、免疫球蛋白 IgA、IgM、IgG 变化情况。结果：与甲组（72.00%）比较，乙组（94.12%）治疗总有效率更高（P＜0.05）；与 甲组比较，乙组各项症状改善时间、住院时间均更短（P＜0.05）；与甲组比较，乙组治疗后 WBC、N 更低（P＜0.05）；与甲组 比较，乙组治疗后免疫球蛋白 IgA、IgM、IgG 水平更高（P＜0.05）。结论：炉甘石洗剂联合苦黄散外洗治疗葡萄球菌性烫伤样 皮肤综合征的临床疗效显著，利于改善临床症状，缩短患儿住院时间，减轻机体感染程度，调节免疫功能。
Abstract:
Objective: To explore the clinical efficacy of calamine lotion combined with Kuhuang powder in the treatment of staphylococcal scalded skin syndrome (SSSS). Methods: 101 children with SSSS who were treated in Wuzhou Hospital of Traditional Chinese Medicine from June 2016 to February 2019 were selected as the research objects and randomly divided into two groups with random number table method. Group a only received conventional western medicine treatment, while group B was treated with calamine lotion combined with Kuhuang powder on the basis of group A. The clinical efficacy, symptom improvement time, hospitalization time, white blood cell count before and after treatment of the two groups, the percentage of neutrophils, changes of immunoglobulin IgA, IgM and IgG were compared. Results: compared with group A (72.00%), the total effective rate of group B (94.12%) was higher (P<0.05) compared with group A, the improvement time of symptoms and hospitalization time of group B were shorter (P<0.05) compared with group A, the WBC and N of group B were lower after treatment (P<0.05) compared with group A, the IgA, IgM and IgG levels of group B were higher after treatment (P<0.05). Conclusion: calamine lotion combined with Kuhuang powder in the treatment ofstaphylococcal scald skin syndrome has significant clinical effect, which is conducive to improving clinical symptoms, shortening hospital stay, reducing the degree of infection and regulating immune function.

参考文献/References:

[1] 郑小涛，李欠颖，曾慧，等. 临床药敏实验对葡萄球菌 性烫伤样皮肤综合征患儿使用抗菌药物的指导意义[J]. 实用药物与临床，2019，22(7): 757-761. [2] 邱建玲，黎雯，符艺影，等. MRSA 葡萄球菌烫伤样皮 肤综合征的临床特点分析[J]. 中华医院感染学杂志， 2019，29(13): 2020-2023. [3] Doudoulakakis A, Spiliopoulou I, Syridou G, et al. Emergence of staphylococcal scalded skin syndrome associated with a new toxinogenic, methicillin-susceptible Staphylococcus aureus clone[J]. Journal of Medical Microbiology, 2019, 68(1): 48-51. [4] 李芳，白美蓉，刘岚丹，等. 保护性护理在 26 例葡萄 球菌烫伤样皮肤综合征的应用[J]. 中国中西医结合皮 肤性病学杂志，2017，16(5): 415-416. [5] Saluzzo S, Layer F, Stingl G, et al. Staphylococcal scalded skin syndrome caused by a rare variant of exfoliative-toxin-A+S. aureus in an adult immunocompromised woman[J]. Acta Dermato-Venereologica, 2018, 98(1): 138-139. [6] 任倩，周爱妍，吴丹，等. 儿童葡萄球菌性烫伤样皮肤 综合征临床及实验室特点分析[J]. 临床皮肤科杂志， 2020，49(1): 11-14. [7] Lamanna O, Bongiorno D, Bertoncello L, et al. Rapid containment of nosocomial transmission of a rare community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) clone, responsible for the Staphylococcal Scalded Skin Syndrome (SSSS)[J]. Italian Journal of Pediatrics, 2017, 43(1): 5. [8] 梅韬，郭普，韩洪方，等. 金黄色葡萄球菌烫伤样皮肤 综合征患者临床分析[J]. 中华医院感染学杂志，2018， 28(23): 3580-3582. [9] 王智斌，赵玢. 炉甘石洗液外用联合加巴喷丁治疗老年 皮肤瘙痒症的疗效观察[J]. 贵州医药，2020，44(10): 94-95. [10] 苏淑真. 金黄色葡萄球菌烫伤样皮肤综合征 56 例患儿的 护理[J]. 基层医学论坛，2019，23(9): 1312-1313. [11] 郭小璇，李云玲. 儿童葡萄球菌性烫伤样皮肤综合征 44 例临床分析[J]. 浙江医学，2019，41(22): 2427-2429. [12] 郭爱红，刘聚红. 地塞米松磷酸钠注射液联合支持疗法 治疗葡萄球菌性烫伤样皮肤综合征临床观察[J]. 社区医 学杂志，2020，18(2): 62-65. [13] 陈青，钟斌，李研，等. 甘露消毒丹加减灌肠、苦黄散 外洗联合干扰素治疗湿热蕴毒型手足口病的疗效及对肝 功能、心肌酶谱、炎症因子、免疫球蛋白的影响[J]. 海 南医学院学报，2019，25(2): 153-156.

备注/Memo

备注/Memo:
【收稿日期】2020-12-10 【作者简介】李研（1982－），女，广西梧州人，梧州市中医医院主治医师，研究方向为临床儿科学。
更新日期/Last Update: 2021-05-19