[1]黎 芳 王志萍 谢谭芳 梁健钦.一种壮药复方对实验性Lewis肺癌小鼠抑瘤作用的初探[J].大众科技,2020,22(12):61-63.
　Preliminary Study on the Anti-Tumor Effect of a Zhuang Medicine Compound on Experimental Lewis Lung Cancer in Mice[J].Popular Science & Technology,2020,22(12):61-63.
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一种壮药复方对实验性Lewis肺癌小鼠 抑瘤作用的初探()
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《大众科技》[ISSN:1008-1151/CN:45-1235/N]

卷:
22
期数:
2020年12
页码:
61-63
栏目:
医药与卫生
出版日期:
2020-12-20

文章信息/Info

Title:
Preliminary Study on the Anti-Tumor Effect of a Zhuang Medicine Compound on Experimental Lewis Lung Cancer in Mice
作者:
黎 芳 王志萍 谢谭芳 梁健钦
（广西中医药大学，广西 南宁 530000）
关键词:
壮药复方; 肺癌; 抑瘤作用; Lewis肺癌小鼠
Keywords:
Zhuang medicine compound lung cancer anti-tumor effect lewis lung carcinoma in mice
文献标志码:
A
摘要:
目的：初步探究该壮药复方制剂实验性Lewis肺癌小鼠抑瘤作用。方法：随机选取C57BL/6小鼠60只，分为空白组、模型组、阳性对照组（DDP 1 mg/kg，隔日给药）、高剂量组（23.44 g/kg）、中剂量组（11.72 g/kg）、低剂量组（5.86 g/kg）6组，每组10只。给药15天后，分离小鼠胸腺，脾脏，肿瘤等组织并称重，计算胸腺指数，脾脏指数，抑瘤率；取血，分离血清，进行肿瘤坏死因子α（TNF-α）水平检测；结果：与模型组比较，壮药复方高、中、低剂量组肿瘤质量显著下降（P＜0.05），抑瘤率分别为26.72%、37.02%、19.85%；壮药复方各组的脾脏指数均显著提高（P＜0.05），壮药复方高、中、低剂量组肿瘤坏死因子α水平均明显升高（P＜0.05）；结论：本实验研究的壮药复方具有抑制肿瘤生长的作用,在一定程度上会激发机体的免疫功能，抗癌机理可能与提升小鼠体内肿瘤坏死因子α的表达、提升小鼠免疫机能有关。
Abstract:
Objective: To explore the antitumor effect of Zhuang medicine compound preparation on Lewis lung cancer in mice. Methods: 60 C57BL/6 mice were randomly selected and divided into 6 groups with 10 mice in each group: blank group, model group, positive control group (DDP 1 mg/kg, administered every other day), high-dose group (23.44 g/kg), medium-dose group (11.72 g/kg), and low-dose group (5.86 g/kg). After 15 days of administration, thymus, spleen, tumor and other tissues were separated and weighed, and thymus index, spleen index and tumor inhibition rate were calculated blood was taken and serum was separated to detect the level of tumor necrosis factor α（TNF-α）. Results: Compared with the model group, the tumor quality of the high-dose, medium-dose and low-dose zhuang medicine compound group decreased significantly (P<0.05), and the tumor inhibition rates were 26.72%, 37.02% and 19.85%, respectively spleen index of all groups was significantly increased (P<0.05), and tumor necrosis factor level was significantly increased in high, medium and low dose groups (P<0.05). Conclusion: The Zhuang medicine compound in this experiment can inhibit tumor growth and stimulate the immune function of the body to a certain extent. The anti-cancer mechanism may be related to enhancing the expression of tumor necrosis factor-α in mice and enhancing the immune function of mice.

参考文献/References:

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备注/Memo

备注/Memo:
【收稿日期】2020-10-09 【基金项目】广西中药制剂共性技术研发重点实验室专项课题（ZJGX2016008）；广西中药制剂共性技术研发重点实验室专项课题（70-ZJGX2017004）。 【作者简介】黎芳（1986－），女，广西桂林人，广西中医药大学讲师，硕士，研究方向为中药新制剂、新技术研究。
更新日期/Last Update: 2021-01-07