[1]秦晓君　李戎基　温广浩.基于NF-κB信号通路治疗腰椎间盘突出症的研究进展[J].大众科技,2020,22(11):96-99.
　Research Progress of Treatment of Lumbar Disc Herniation Based onNF-κB Signal Pathway[J].Popular Science & Technology,2020,22(11):96-99.
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基于NF-κB信号通路治疗腰椎间盘突出症的 研究进展()
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《大众科技》[ISSN:1008-1151/CN:45-1235/N]

卷:
22
期数:
2020年11
页码:
96-99
栏目:
医药与卫生
出版日期:
2020-11-20

文章信息/Info

Title:
Research Progress of Treatment of Lumbar Disc Herniation Based on NF-κB Signal Pathway
作者:
秦晓君　李戎基　温广浩
（广西中医药大学研究生院，广西 南宁 530023）
关键词:
NF-κB; 腰椎间盘突出症; 综述
Keywords:
NF-κB lumbar disc herniation review
文献标志码:
A
摘要:
NF-κB（NF-kappa B）是一种常见的核转录因子，于细胞质中广泛存在，并在细胞受到刺激时起着信号通路的作用，通过调节趋化细胞因子、黏附分子、生长因子及多种酶的基因表达，在机体的炎性反应、免疫调节及细胞凋亡中起着重要作用。目前主流学说认为椎间盘突出症产生疼痛的重要原因是炎症反应机制。据相关报道证实，在炎症反应中，NF-kB信号通路会直接影响相关炎性因子的分泌及相关信号分子的表达，进而影响炎症反应的进程。文章通过论述NF-κB的结构特点、相关信号传导激活途径、腰椎间盘突出症的病因病机理论、NF-κB信号通路与腰椎间盘突出症的联系以及基于NF-κB信号通路治疗腰椎间盘突出症的近年概况，探讨基于NF-κB信号通路治疗腰椎间盘突出症的作用机制，为今后临床中治疗腰椎间盘突出症提供参考依据。
Abstract:
NF-κB (NF-kappa B) is a common nuclear transcription factor, widely present in the cytoplasm, and acts as a signaling pathway when cells are stimulated. By regulating chemotactic cytokines, adhesion molecules, gene expression of growth factors and various enzymes, plays an important role in the bodys inflammatory response, immune regulation and apoptosis. At present, the mainstream doctrine believes that the important reason for pain caused by disc herniation is the inflammatory response mechanism. According to relevant reports, in the inflammatory response, the NF-kB signaling pathway directly affects the secretion of related inflammatory factors and the expression of related signaling molecules, which in turn affects the progress of the inflammatory response. This article discusses the structural characteristics of NF-κB, related signaling activation pathways, the etiology and pathogenesis theory of lumbar disc herniation, the connection between NF-κB signaling pathway and lumbar disc herniation, and the treatment of lumbar disc herniation based on NF-κB signaling pathway in recent years, to explore the mechanism of treatment of lumbar disc herniation based on NF-κB signaling pathway, and provide a reference for the future clinical treatment of lumbar disc herniation.

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备注/Memo

备注/Memo:
【收稿日期】2020-09-11 【作者简介】秦晓君（1994—），女，广西贺州人，广西中医药大学研究生院在读硕士研究生，研究方向为脊柱退行性疾病的中西医治疗。
更新日期/Last Update: 2020-12-17