[1]宋世雷 占华松 沈欣欣.负压引流技术促进生长因子在糖尿病足溃疡中表达的研究[J].大众科技,2020,22(11):75-78.
　Study on the Promotion of Growth Factor Expression in Diabetic Foot Ulcer by Negative Pressure Drainage Technology[J].Popular Science & Technology,2020,22(11):75-78.
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负压引流技术促进生长因子在糖尿病足溃疡中表达的研究()
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《大众科技》[ISSN:1008-1151/CN:45-1235/N]

卷:
22
期数:
2020年11
页码:
75-78
栏目:
医药与卫生
出版日期:
2020-11-20

文章信息/Info

Title:
Study on the Promotion of Growth Factor Expression in Diabetic Foot Ulcer by Negative Pressure Drainage Technology
作者:
宋世雷 占华松 沈欣欣
（广西中医药大学，广西 南宁 530001）
关键词:
糖尿病足; 负压引流技术; 生长因子
Keywords:
diabetic foot negative pressure drainage technology growth factor
文献标志码:
A
摘要:
糖尿病足溃疡（Diabetic foot ulcer）是一种多因下肢远端周围神经病变、血管病变、代谢紊乱、感染等因素导致局部浅表皮肤及深层组织发生溃疡，坏死的慢性难愈性创面。若早期不及时处理容易进一步发展为足部气性或湿性坏疽，甚至出现全身性感染，患者将面临截肢可能甚至有生命危险，现已成为骨科临床常见慢性病及难题。目前糖尿病足溃疡的治疗主要包括皮瓣移植、抗生素骨水泥覆盖引流术、血管重建技术、负压封闭引流技术等。其中负压封闭引流技术可通过相关生长因子作用机制恢复创面供血、促进肉芽组织生长、降低炎性反应、促进表皮恢复、消除组织水肿及降低感染，并且治疗效果显著，因此备受广大临床医生的青睐，但是尚未有研究对其作用糖尿病足溃疡的相关生长因子机制做进一步综述研究。文章通过阐述负压引流作用下，糖尿病足溃疡中相关生长因子作用机制，为临床负压引流技术治疗糖尿病足溃疡做基础研究。
Abstract:
Diabetic foot ulcer (DFU) is a chronic and refractory wound with ulcer and necrosis of local superficial skin and deep tissue caused by peripheral neuropathy, vascular disease, metabolic disorder, infection and other factors. If early treatment is not timely, it is easy to further develop into foot gas or wet gangrene, or even systemic infection, patients will face amputation and may even have life-threatening, which has become a common chronic disease and difficult problem in orthopedics clinic. At present, the treatment of diabetic foot ulcer mainly includes skin flap transplantation, antibiotic bone cement covering drainage, vascular reconstruction technology, vacuum sealing drainage technology and so on. Vacuum sealing drainage technology can restore blood supply to wound surface, promote granulation tissue growth, reduce inflammatory reaction, promote epidermal recovery, eliminate tissue edema and reduce infection through the mechanism of related growth factors, and the treatment effect is significant, so it is favored by the majority of clinicians, but there has been no further review on the mechanism of growth factor in diabetic foot ulcer. In this paper, the mechanism of related growth factors in diabetic foot ulcer under the effect of negative pressure drainage was elaborated, which would be the basic research for the clinical treatment of diabetic foot ulcer with negative pressure drainage technology.

参考文献/References:

[1]　Carracher A M, Marathe P H, Close K L. International Diabetes Federation 2017[J]. Journal of Diabetes, 2018, 10(5): 353-356. [2]　杨文英. 中国糖尿病的流行特点及变化趋势[J]. 中国科学(生命科学)，2018，48(8): 812-819. [3]　Miyajima S, Shirai A, Yamamoto S, Okada N, Matsushita T. Risk factors for major limb amputations in diabetic foot gangrene patients[J]. Diabetes Research and Clinical Practice, 2006, 71(3): 272-279. [4]　Lampert C, Bösch F, Werner J, et al. Komorbiditäten gefährden die Wundheilung [Effects of comorbidities on wound healing][J]. MMW Fortschritte der Medizin, 2019, 161(20): 54-59. [5]　Pei X W, Wang K Z, Dang X Q, et al. Arnebia root oil promotes wound healing and expression of basic fibroblast growth factor on the wound surface in rabbits[J]. Journal of Chinese Integrative Medicine, 2006, 4(1): 52-55. [6]　Zubair M, Ahmad J. Role of growth factors and cytokines in diabetic foot ulcer healing: A detailed review[J]. Reviews in Endocrine and Metabolic Disorders, 2019, 20(8): 207-217. [7]　杨宗保，严洁. 表皮生长因子受体及其信号转导通路与胃粘膜损伤修复研究[J]. 中医药导报，2006，12(3): 66-68. [8]　史怀平. 表皮生长因子(EGF)介导的MAPK/PI3K/PLC-γ1信号通路关键信号蛋白活性研究[D]. 咸阳: 西北农林科技大学，2011. [9]　Ko J, Jun H, Chung H, et al. Comparison of EGF with VEGF non-viral gene therapy for cutaneous wound healing of streptozotocin diabetic mice. Diabetes and Metabolism Journal, 2011, 35(3): 226-235. [10] Xiao S C, Zhu S H, Xia Z F et al. Reconstruction and transplantation of the composite skin comprising epithelial growth factor gene-transfected keratinocytes[J]. Zhongguo Yi Xue Ke Xue Yuan Xue Bao, 2007, 29(4): 506-509. [11] 刘碧贤. 表皮因子配伍胰岛素在糖尿病慢性伤口愈合中的应用[J]. 糖尿病新世界，2018，21(13): 102-103. [12] 雄婉玲. 重组人表皮生长因子凝胶在儿童浅Ⅱ度烧伤创面中的疗效研究[J]. 中国医药指南，2018，16(34): 138. [13] Galkowska H, Wojewodzka U, Olszewski WL. Chemokines, cytokines, and growth factors in keratinocytes and dermal endothelial cells in the margin of chronic diabetic foot ulcers[J]. Wound Repair and Regeneration, 2006, 14(5): 558-565. [14] 汤苏阳，李春伶，董继红，等. 封闭负压引流对创伤愈合中周围神经末梢分泌的P物质及表皮生长因子表达的影响[J]. 中国临床康复，2004，(32): 7171-7173. [15] 许传秀，邓秋奎，黄冬梅，等. 封闭负压吸引联合生长因子治疗糖尿病足溃疡[J]. 中外女性健康研究，2016(16): 216，224. [16] 张曼，戴丽芬，田福璐，等. 糖尿病肾病发生发展的相关危险因素[J]. 中国老年保健医学，2020，18(2): 80-82. [17] Lin D, Harris R, Stutzman R, et al. Protein kinase C-gamma activation in the early streptozotocin diabetic rat lens[J]. Current eye research, 2007, 32(6): 523-532. [18] Cuadrado A, Nebreda A R. Mechanisms and functions of p38 MAPK signalling[J]. Biochemical Journal,. 2010, 429(3): 403-417. [19] 王师英，孙博云，林江，等. VEGFR2在血管新生与重塑中的调控作用[J]. 中国老年学杂志，2017(19): 4924-4927. [20] Gallagher KA, Liu ZJ, Xiao M, et al. Diabetic impairments in NO-mediated endothelial progenitor cell mobilization and homing are reversed by hyperoxia and SDF-1 alpha[J]. Journal of Clinical Investigation, 2007, 117(5): 1249-1259. [21] 付汉东，张爱华，鲁艳，等. 自体骨髓干细胞移植治疗糖尿病足患者血管内皮生长因子的表达及意义[J]. 中国全科医学，2010，13(23): 2554-2556. [22] 许丽华，赵胜元，胡丽格，等. 负压封闭引流技术在糖尿病足溃疡治疗机制分析[J]. 大家健康(下旬版)，2016，10(3): 89-90. [23] 胡祥，余国荣，刘兴邦，等. 封闭负压引流技术对创面血管化的影响[J]. 医学新知杂志，2008，18(4): 211-212，216. [24] Morykwas M J, Argenta L C, Shelton E, et al. Vacuum- assisted closure: a new method for wound control and treatment: animal studies and basic foundation[J]. Annals of Plastic Surgery, 1997, 38(6): 553-562. [25] Brem H, Tomic-Canic M. Cellular and molecular basis of wound healing in diabetes{J}. The Journal of clinical investigation, 2007, 117(5): 1219-1222. [26] Xuan Y H, Huang B B, Tian H S, et al. High-glucose inhibits human fibroblast cell migration in wound healing via repression of bFGF-regulating JNK phosphorylation[J]. PLoS One, 2014, 9(9): e108182. [27] Tomasek J J, Gabbiani G, Hinz B, et al. Myofibroblasts and mechano-regulation of connective tissue remodelling[J]. Nature Reviews Molecular Cell Biology, 2002, 3(5): 349-363. [28] Hinz B, Phan S H, Thannickal V J, et al. Recent developments in myofibroblast biology: paradigms for connective tissue remodeling[J]. The American Journal of Pathology., 2012, 180(4): 1340-1355. [29] 潘良利，程飚. 糖尿病微血管形成障碍所涉及的重要组织结构与晚期糖基化终末产物的关系[J]. 感染、炎症、修复，2015，16(3): 189-192. [30] 姚忠祥，孙榆，刘建军，等. 碱性成纤维细胞生长因子促进脑室管膜前下区细胞增殖的实验研究[J]. 中国临床康复，2004(4): 644-645，809. [31] Bai Y P, Shang K, Chen H, et al. FGF-1/-3/FGFR4 signaling in cancer-associated fibroblasts promotes tumor progression in colon cancer through Erk and MMP-7[J]. Cancer Science, 2015, 106(10): 1278-1287. [32] 姜强，李建婷，娄凯，等. 创面负压治疗促进碱性成纤维细胞生长因子(bFGF)在糖尿病足肉芽组织表达[J]. 双足与保健，2017，26(15): 59-60. [33] 黄宇斌，陈武斌，胡检，等. bFGF联合局部氧疗促进深Ⅱ度烧伤创面愈合的临床研究[J]. 亚太传统医药，2012，8(11): 147-148. [34] Asanome A, Kawabe J, Matsuki M, et al. Nerve growth factor stimulates regeneration of perivascular nerve, and induces the maturation of microvessels around the injured artery. Biochem Biophys Res Commun. 2014, 443(1): 150-155. [35] 汤苏阳，陈绍宗，胡昭华，等. 封闭负压引流技术对失感觉神经支配创伤愈合中Bcl-2与NGF/NGFmRNA表达的影响[J]. 第四军医大学学报，2005(2): 163. [36] 武姗. TGF-βRⅠ在糖尿病足创面肉芽组织中的表达[D]. 石家庄: 河北医科大学，2017. [37] 孙俊超. 封闭负压引流技术联合清创处理治疗糖尿病足的临床效果观察[J]. 医学理论与实践，2019，32(16): 2587-2588. [38] 吾甫尔?马尔，李新喜，苗玉堂，等. 负压封闭引流个体化治疗糖尿病足的疗效及对血清降钙素原、血浆纤维粘接蛋白和肉芽组织转化生长因子β1水平的影响[J]. 中国血管外科杂志(电子版)，2018，10(3): 204-207. [39] Semenova E, Koegel H, Hasse S, et al. Overexpression of mIGF-1 in keratinocytes improves wound healing and accelerates hair follicle formation and cycling in mice[J]. The American Journal of Pathology, 2008, 173(5): 1295-1310. [40] 王强. 持续性封闭负压引流治疗对糖尿病足患者血清IGF1、NO水平的影响[J]. 国际检验医学杂志，2018，39(1): 63-66.

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备注/Memo

备注/Memo:
【收稿日期】2020-09-05 【基金项目】广西中医药大学2019年校级创新课题（YCSY20190079）；广西中医药大学2020年校级创新课题（YCSY2020058）。 【作者简介】宋世雷（1994－），男，浙江平阳人，广西中医药大学在读硕士研究生，研究方向为关节与运动相关疾病的中西医结合治疗。 【通信作者】占华松（1991－），男，江西九江人. 广西中医药大学在读硕士研究生，研究方向为关节与运动相关疾病的中西医结合治疗。
更新日期/Last Update: 2020-12-17