[1]蒋 鹏 高宏君 梁泰生 吴玲玲 武 桢.基于网络药理学探究车前子治疗 慢性前列腺炎的作用机制研究[J].大众科技,2020,22(08):50-55.
　Research on the Mechanism of Plantain Seed in the Treatment of Chronic Prostatitis Based on Network Pharmacology[J].Popular Science & Technology,2020,22(08):50-55.
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基于网络药理学探究车前子治疗 慢性前列腺炎的作用机制研究()
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《大众科技》[ISSN:1008-1151/CN:45-1235/N]

卷:
22
期数:
2020年08
页码:
50-55
栏目:
医药与卫生
出版日期:
2020-08-20

文章信息/Info

Title:
Research on the Mechanism of Plantain Seed in the Treatment of Chronic Prostatitis Based on Network Pharmacology
作者:
蒋 鹏 高宏君 梁泰生 吴玲玲 武 桢
（广西中医药大学附属瑞康医院，广西 南宁 530011）
关键词:
车前子; 慢性前列腺炎; 网络药理学; 作用机制
Keywords:
plantain seed chronic prostatitis network pharmacology mechanism of action
文献标志码:
A
摘要:
目的：利用网络药理学探究车前子治疗慢性前列腺炎的作用机理。方法：通过中药系统药理学技术平台（TCMSP） 数据库，以化合物口服药物生物利用度（OB）和类药性（DL）为标准，预测并筛选车前子的化合物及作用靶点。通过 Gene Cards 数据库筛选慢性前列腺炎的靶标基因，通过 Venny2.1 数据库获得车前子对慢性前列腺炎的相关靶点，应用 STRING 数据库进行 蛋白互作网络分析，以 Cytoscape3.6.1 软件构建车前子化合物-靶点网络图，利用 David6.8 数据库进行 GO 分析和 KEGG 信号通 路富集分析。结果：从车前子中筛选获得包括 7 个化学成分，作用于 23 个慢性前列腺炎靶点，主要靶点包括抗肿瘤 P53 抗体、 雄激素受体、白细胞介素 6、白细胞介素 1、表皮生长因子、BCL2 凋亡调节器、血管内皮细胞生长因子 A 等。结论：车前子可 能主要通过抗炎、抗氧化、扩张血管、抑制细胞凋亡等方面来治疗慢性前列腺炎。
Abstract:
Objectives: To explore the mechanism of plantain seed in the treatment of chronic prostatitis by network pharmacology. Methods: Through the Chinese medicine system pharmacology technology platform (TCMSP) database, the bioavailability (OB) and drug like (DL) of oral drugs were used as the standards to predict and screen the plantain seed compounds and targets. Target genes for chronic prostatitis were screened by Gene Cards database. Venny2.1 tool was used to obtain relevant targets of plantain seed for chronic prostatitis. The protein interaction network was analyzed by STRING database. Cytoscape3.6.1 software was used to construct the plantain seed compound target network diagram. GO analysis and KEGG pathway enrichment analysis were carried out using David6.8 database. Results: 7 chemical components were screened from plantain seed, acting on 23 targets of chronic prostatitis. The main targets include tumor protein P53, androgen receptor, interleukin 6, interleukin 1, epidermal growth factor, BCL2 apoptosis regulator, vascular endothelial growth factor A, etc. Conclusion: Plantain seed may treat chronic prostatitis mainly through anti-inflammatory, anti-oxidation, vasodilation, inhibition of apoptosis and other aspects.

参考文献/References:

[1] 姜智虎. 前列汤治疗湿热瘀阻型慢性前列腺炎及疼痛疗 效观察[J]. 陕西中医，2012，33(12): 1590-1591. [2] 李海松，王彬，赵冰. 慢性前列腺炎中医诊治专家共识[J]. 北京中医药，2015，34(5): 412-415. [3] Mishra V C, Browne J, Emberton M. Role of repeated prostatic massage in chronic prostatitis: a systematic review of the literature[J]. Urology, 2008, 72(4): 731-735. [4] Li H C, Wang Z L, Li H L, et al. Correlation of the prognosis of chronic prostatitis/chronic pelvic pain syndrome with psychological and other factors: a Cox regression analysis[J]. National Journal of Andrology, 2008, 14(8): 723-727. [5] 郁春，陈东，王家辉. 三联疗法治疗气滞血瘀型慢性前 列腺炎 31 例[J]. 辽宁中医杂志，2012，39(3): 479-480. [6] Magistro G, Wagenlehner F M E, Grabe M, et al. Contemporary management of chronic prostatitis/chronic pelvic pain syndrome[J]. European Urology, 2015, 69(2): 286-297. [7] 国家药典委员会. 中华人民共和国药典: 一部[M]. 北京: 中国医药科技出版社，2015: 68-69. [8] 黄丹菲，聂少平，江乐明，等. 乙酰化大粒车前子多糖 的制备及其活性研究[J]. 食品科学，2013，34(22): 1-4. [9] 斯日棍其其格，董成海. 车前子的化学成分及药理学研 究[J]. 世界最新医学信息文摘，2017，17(94): 97-98. [10] 李晓阳，高旋慰. 化浊通瘀汤配合直肠滴入治疗湿热瘀 阻型前列腺炎 84 例[J]. 陕西中医，2014(9): 1205- 1207. [11] 潘俊杰，李结实，金星，等. 慢性前列腺炎的辨证分型与 治疗观察[J]. 四川中医，2011，29(11): 57-59. [12] 秦国政. 中医男科学[M]. 北京: 科学出版社，2017. [13] Barton B E. IL-6: insights into novel biological activities[J]. linical Immunology and Immunopathology, 1997, 85(1): 16-20. [14] 叶海云，侯树坤，白文俊，等. 慢性前列腺炎患者前列 腺液 IL-6 和 IL-8 表达变化及意义[J]. 中华泌尿外科杂 志，2003，24(4): 279-281. [15] Schaeffer A J. Evaluation of the cytokines in genital secretions of patients with chronic prostatitis[J]. Journal of Urology, 2005, 173(3): 844-845． [16] John H, Barghorn A, Funke G, et al. Noninflammatory chronic pelvic pain syndrome: immunological study in blood, ejaculate and prostate tissue[J]. European Urology, 2001, 39(1): 72-78. [17] Yokota T，Wang Y. p38 MAPK inases in the heart[J]. Gene, 2016, 575(2): 369-376. [18] Park K R, Nam D, Yun H M, et al. β-Caryophyllene oxide inhibits growth and induces apoptosis through thesuppression of PI3 K/AKT/mTOR/S6K1 pathways and ROS-mediated MAPKs activation[J]. Cancer Letters. 2011, 312(2): 178-188. [19] Min Y D, Choi C H, Bark H, et al. Quercetin inhibits expression of inflammatory cytokines through attenuation of NF-κB and p38 MAPK in HMC-1 human mast cell line[J]. Inflammation Research, 2007, 56 (5): 210-215. [20] Ying B, Yang T, Song X, et al. Quercetin inhibits IL-1 beta-induced ICAM-1 expression in pulmonary epithelial cell line A549 through the MAPK pathways[J]. Molecular Biology Reports, 2009, 36 (7): 1825-1832. [21] Ma J Q, Li Z, Xie W R, et al. Quercetin protects mouse liver against CCl4-induced inflammation by the TLR2/4 and MAPK/NF-κB pathway[J]. International Immunopharmacology, 2015, 28(1): 531-539. [22] 张国红，陈宋明. 冠心病患者缺氧诱导因子-1α 与血红素 氧化酶-1 的相关性研究[J]. 中国全科医学，2011，14(15): 1662-1664. [23] Schönenberger D, Harlander S, Rajski M, et al． Formation of renal cysts and tumors in Vhl/Trp53-deficient mice requires HIF1α and HIF2α[J]. Cancer Research, 2016, 76(7): 2025-2036. [24] 贾云波，杜惠兰，高星，等. 补肾温阳化瘀方对子宫内 膜异位症肾阳虚血瘀证模型大鼠 HIF-1α、PHD2、VHL 表达的影响[J]. 中国中西医结合杂志，2015，35(10): 1210- 1217. [25] Shin, S. Y, Woo Y, Hyun J, et al. Relationship between the structures of flavonoids and their NF-κB-dependent transcriptional activities[J]. Bioorganic and Medicinal Chemistry Letters, 2011, 21(20): 6036-6041. [26] 王辉，何柏球，王立英，等. 高车前苷改善棕榈酸所致 的血管内皮细胞凋亡[J]. 中药药理与临床，2014(3): 39-42. [27] Boots A W, Haenen G, Bast A. Health effects of quercetin: from antioxidant to nutraceutical[J]. European Journal of Pharmacology, 2008, 585(2-3): 325-337. [28] Materska, M. Quercetin and its derivatives: chemical structure and bioactivity-a review[J]. Polish Journal of Food and Nutrition Sciences, 2008, 58(4): 407-413. [29] Mishurov D A, Voronkin A A, Roshal A D. Synthesis, molecular structure and optical properties of glycidyl derivatives of quercetin[J]. Structural Chemistry , 2016, 27 (1): 285-294. [30] Chirumbolo S. The role of quercetin, flavonols and flavones in modulating inflammatory cell function[J]. Inflammation and Allergy-Drug Targets, 2010, 9(4): 263-285. [31] Xu X R, Yu H T, Yang Y, et al. Quercetin phospholipid complex significantly protects against oxidative injury in ARPE-19 cells associated with activation of Nrf2 pathway[J]. European Journal of Pharmacology, 2016, 770(5): 1-8. [32] 姚凤，周清燕，熊瑛，等. β-谷甾醇对脂多糖诱导的小鼠 急性肺损伤的保护作用研究[J]. 中国农学通报，2015， 31(2): 55-61.

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备注/Memo

备注/Memo:
【收稿日期】2020-06-11 【基金项目】广西壮族自治区中青年教师基础能力提升项目（2019KY0317）；广西中医药大学 2019－2011 年广西一流 学科建设项目青年基金项目（2019XK176）；广西壮族自治区中青年教师基础能力提升项目（KY2015LX144）。 【作者简介】蒋鹏，广西中医药大学附属瑞康医院住院医师，硕士，研究方向为器官移植泌尿外科。
更新日期/Last Update: 2020-11-17