[1]江家鹏,黄菊芳,张扬武.熊果酸抑制肝纤维化的研究进展[J].大众科技,2020,22(05):33-36.
　Research Progress of Ursolic Acid in Inhibiting Against Liver Fibrosis[J].Popular Science & Technology,2020,22(05):33-36.
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熊果酸抑制肝纤维化的研究进展()
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《大众科技》[ISSN:1008-1151/CN:45-1235/N]

卷:
22
期数:
2020年05
页码:
33-36
栏目:
轻工与化工
出版日期:
2020-05-20

文章信息/Info

Title:
Research Progress of Ursolic Acid in Inhibiting Against Liver Fibrosis
作者:
江家鹏1;  黄菊芳 2;  张扬武 3
（1.广西中医药大学第一附属医院，广西 南宁 530023；2.广西中医药大学研究生学院，广西 南宁 530001；3.广西国际壮医医院，广西 南宁 530000）
关键词:
熊果酸; 肝纤维化; 作用机制; 研究进展
Keywords:
ursolic acid;  liver fibrosis;  mechanism of action;  research progress
文献标志码:
A
摘要:
熊果酸（Ursolic acid，UA）是一种主要存在于大多数植物中的天然化合物，前期实验研究发现 UA 通过调节多条信号通路、抑制氧化应激、诱导肝星状细胞（Hepatic stellate cell，HSC）凋亡，改善肠道粘膜屏障，进而促进肝小叶中央区坏死肝细胞修复，从而起到抗肝纤维化的作用。为更好开发利用 UA，文章就 UA 抑制肝纤维化的作用及其机制展开论述。
Abstract:
Ursolic acid (UA) is a kind of natural compound mainly existing in most plants. Previous studies found that UA canregulate multiple signal pathways, inhibit oxidative stress and induce hepatic stellate cells (HSC) apoptosis, improve intestinal mucosalbarrier, and then promote the repair of necrotic hepatocytes in the central area of liver lobule, so as to play an anti fibrosis role. In order tomake better use of UA, this paper discusses the role and mechanism of UA in inhibiting liver fibrosis.

参考文献/References:

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备注/Memo

备注/Memo:
【收稿日期】2020-03-09【基金项目】广西高校中青年教师科研基础能力提升项目（2019KY0351）。【作者简介】江家鹏（1978－），男，广西南宁人，广西中医药大学第一附属医院胃肠肛门外科主治医师，研究方向为中医药防治消化系统疾病。【通信作者】张扬武（1987－），男，广西来宾人，广西国际壮医医院医师，研究方向为中医药防治消化系统疾病。
更新日期/Last Update: 2020-08-04