[1]覃旭胜,林自进,潘桂恒,等.血管性痴呆:临床病理和遗传学考虑[J].大众科技,2020,22(03):91-94.
 Vascular Dementia: Clinicopathological and Genetic Considerations[J].Popular Science & Technology,2020,22(03):91-94.
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血管性痴呆:临床病理和遗传学考虑()
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《大众科技》[ISSN:1008-1151/CN:45-1235/N]

卷:
22
期数:
2020年03
页码:
91-94
栏目:
医药与卫生
出版日期:
2020-03-20

文章信息/Info

Title:
Vascular Dementia: Clinicopathological and Genetic Considerations
作者:
覃旭胜1 林自进 1 潘桂恒 1 谭文澜 2
(1.广西中医药大学,广西 南宁 530001;2.广西中医药大学附属瑞康医院,广西 南宁 530011)
关键词:
缺血性血管性痴呆(IVD)中风--微梗死脑-CADASIL--CARASIL-脑视网膜血管病(CRV)
Keywords:
ischemic vascular dementia (IVD) stroke - micro infarction brain - CADASIL - CARASIL - cerebrovascular disease(CRV)
文献标志码:
A
摘要:
随着年龄的增长,脑血管病(CVD)的发病率和严重程度都会增加,患阿尔茨海默病(AD)的风险也会增加。在“老化的大脑”中,不同形式的脑血管病可能与 AD 变化并存。这些疾病包括由“经典”危险因素(高血压、吸烟、糖尿病)引起的血管病变(影响大动脉和小动脉)和其他与 AD 生化密切相关的疾病(脑淀粉样血管病)。这些不同血管疾病的形态学结果是脑内不同大小的梗死和或出血,这会导致神经认知能力下降,这可能类似于 AD,尽管血管异常通常可以通过神经成像检测到。脑血管病更微妙的影响可能包括神经炎症和生化“损伤”,这些损伤没有可靠的形态学联系,因此即使是有经验的神经病理学家也不会注意到。类似缺血性改变的海马损伤的发病机制,通常见于老年受试者的大脑。近年来,基因决定的微血管病变(如 CADASIL、CARASIL、TREX1 相关的微血管病变、CARASAL、CAA),为散发性微血管疾病(如动脉硬化和 AD 相关的CAA)的发病机制提供了有趣的细胞和分子线索。
Abstract:
With the increase of age, the incidence and severity of cerebrovascular disease (CVD) will increase, and the risk ofAlzheimer’s disease (AD) will also increase. In "aging brain", different forms of cerebrovascular diseases may coexist with AD changes.These diseases include vascular diseases (affecting large and small arteries) caused by "classic" risk factors (hypertension, smoking,diabetes) and other diseases closely related to AD biochemistry (cerebral amyloid angiopathy). The morphological results of these differentvascular diseases are infarction and / or hemorrhage of different sizes in the brain, which can lead to a decline in neurocognitive ability,which may be similar t AD, although vascular abnormalities can usually be detected by neuroimaging. The more subtle effects ofcerebrovascular disease may include neuroinflammation and biochemical "damage," which has no reliable morphological connection, soeven experienced neuropathologists will not notice. The pathogenesis of hippocampal injury similar to ischemic changes, usually seen inthe brain of elderly subjects, is still controversial. In recent years, gene determined microvascular diseases (such as CADASIL, CARASIL,TREX1 related microvascular diseases, carasal, familial cerebral amyloid angiopathy or CAA) provide interesting cellular and molecularclues for the pathogenesis of sporadic microvascular diseases (such as arteriosclerosis and AD related CAA).

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备注/Memo

备注/Memo:
【收稿日期】2020-01-07【作者简介】覃旭胜(1993-),男,广西平南人,广西中医药大学在读硕士研究生,研究方向为中西医结合临床。
更新日期/Last Update: 2020-05-25