[1]张跃龄,黄君玲,张 健,等.丁苯酞联合阿司匹林对腔隙性脑梗死患者细胞因子、血流循环及脑部血管的影响[J].大众科技,2019,21(08):71-74.
　Effects of Butylphthalide Combined with Aspirin on Cytokines, Blood Circulationand Cerebral Vessels in Patients with Lacunar Infarction[J].Popular Science & Technology,2019,21(08):71-74.
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丁苯酞联合阿司匹林对腔隙性脑梗死患者细胞因子、血流循环及脑部血管的影响()
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《大众科技》[ISSN:1008-1151/CN:45-1235/N]

卷:
21
期数:
2019年08
页码:
71-74
栏目:
医药与卫生
出版日期:
2019-08-20

文章信息/Info

Title:
Effects of Butylphthalide Combined with Aspirin on Cytokines, Blood Circulationand Cerebral Vessels in Patients with Lacunar Infarction
作者:
张跃龄1;  黄君玲 2;  张 健 1;  骆静连 1;  唐 健 1;  谭 忠 2;  石胜良 1
（1.广西医科大学第二附属医院，广西 南宁 530000；2.广西医科大学，广西 南宁 530000）
关键词:
腔隙性脑梗死; 丁苯酞; 阿司匹林; 细胞因子; 血流循环; 脑部血管
Keywords:
lacunar infarction;  Butylphthalide;  Aspirin;  cytokines;  blood circulation;  cerebral vessels
文献标志码:
A
摘要:
目的：探讨丁苯酞联合阿司匹林对腔隙性脑梗死（LI）患者细胞因子、血流循环及脑部血管的影响。方法：选取 2018 年 1 月至 2019 年 4 月我院 106 例 LI 患者，按随机抽签法分为对照组与观察组，各 53 例。对照组采取阿司匹林治疗，观察组采取丁苯酞联合阿司匹林治疗，均治疗 3 周。观察两组疗效、不良反应发生率与治疗前后血清细胞因子有关指标［C 反应蛋白（CRP）、白细胞介素-8（IL-8）］、血流动力学有关指标（大脑中动脉的收缩期峰流速/舒张期峰流速、搏动指数、阻力指数）、血液流变学有关指标（血浆黏度、全血黏度切变率、纤维蛋白原）、脑部血管功能有关指标（脑内动脉的血液流入时间、脑血流量）水平。结果：观察组治疗 3 周后总有效率 94.34%高于对照组 73.58%（P＜0.05）；两组治疗前血清 CRP、IL-8 水平对比，差异无统计学意义（P＞0.05），与对照组对比，观察组治疗 3 周后血清 CRP、IL-8 水平较低（P＜0.05）；与对照组对比，观察组治疗 3 周后大脑中动脉的收缩期峰流速/舒张期峰流速、搏动指数、阻力指数与血浆黏度、全血黏度切变率、纤维蛋白原水平较低（P＜0.05）；观察组治疗 3 周后脑血流量高于对照组（P＜0.05）；观察组不良反应发生率 11.32%与对照组 7.55%相比，差异无统计学意义（P＞0.05）。结论：腔隙性脑梗死患者予以丁苯酞联合阿司匹林治疗可显著提高疗效，改善细胞因子水平与脑部血管功能，加速脑部血液循环，且具有较高安全性。
Abstract:
Objective: To investigate the effect of butylphthalide combined with aspirin on cytokines, blood circulation and cerebralvessels in patients with lacunar infarction (LI). Methods: A total of 106 cases of LI patients in the Second Affiliated Hospital of GuangxiMedical University from January 2018 to April 2019 were selected and divided into the control group and the observation group accordingto the random draw method, each with 53 cases. The control group was treated with aspirin, and the observation group was treated withbutylphthalide combined with aspirin. Both were treated for 3 weeks. The curative effect, the incidence of adverse reaction reaction and thelevels of serum cytokine related indexes [C reactive protein (CRP), interleukin -8 (IL-8)] before and after treatment, the hemodynamicindexes (the systolic peak velocity / diastolic peak velocity of the cerebral artery, pulsation index, resistance index), the related indexes ofhemorheology (plasma viscosity, total blood viscosity shear rate, fibrinogen), and the related indexes of cerebral vascular function (theblood flow time of the intracerebral artery and the flow of cerebral blood) of the two groups were observed. Results: The total effective rateof the observation group after 3 weeks of treatment was 94.34%, higher than that of the control group (73.58%)(P＜0.05). There wasinsignificant difference in levels of serum CRP and IL-8 between the two groups before treatment（P＞0.05）. Compared with the controlgroup, the levels of serum CRP and IL-8 were lower in the observation group after 3 weeks of treatment(P＜0.05). Compared with thecontrol group, the levels of the systolic peak velocity / diastolic peak velocity of the cerebral artery, the pulsation index, the resistance index,the plasma viscosity, the total blood viscosity shear rate and the fibrinogen were lower in the observation group after 3 weeks of treatment(P＜0.05). The cerebral blood flow of the observation group after 3 weeks of treatment was higher than that of the control group(P＜0.05).There was insignificant difference in the incidence of adverse reaction between the observation group (11.32%) and the control group(7.55%)(P＞0.05). Conclusion: Butylphthalide combined with aspirin in patients with lacunar infarction can significantly improve thecurative effect, improve the level of cytokine and cerebral vascular function and accelerate the blood circulation of the brain. Besides, it hashigh safety.

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备注/Memo

备注/Memo:
【收稿日期】2019-06-11【基金项目】丁苯酞联合阿司匹林对腔隙性脑梗死患者认知障碍的临床研究（Z20181000）。【作者简介】张跃龄（1983－），女，广西玉林人，广西医科大学第二附属医院神经内科主治医师，广西医科大学硕士研究生，研究方向为痴呆及脑血管病。【通信作者】石胜良，广西医科大学第二附属医院神经内科主治医师，研究方向为痴呆、脑血管病、神经介入。
更新日期/Last Update: 2020-01-22