[1]邓海霞,陀 鹏,赵 旋,等.早期联合参附注射液对心肺复苏患者心功能不全的临床观察[J].大众科技,2019,21(07):57-60.
　Clinical Observation of Early Combined with Shenfu Injection on CardiacInsufficiency in Patients with Cardiopulmonary Resuscitation[J].Popular Science & Technology,2019,21(07):57-60.
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早期联合参附注射液对心肺复苏患者心功能不全的临床观察()
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《大众科技》[ISSN:1008-1151/CN:45-1235/N]

卷:
21
期数:
2019年07
页码:
57-60
栏目:
医药与卫生
出版日期:
2019-07-20

文章信息/Info

Title:
Clinical Observation of Early Combined with Shenfu Injection on CardiacInsufficiency in Patients with Cardiopulmonary Resuscitation
作者:
邓海霞1;  陀 鹏 1;  赵 旋 2;  吴瑞华 2;  贾 思 2;  黄 丹 1;  蓝 洲 1;  颜宁钟 1
（1.广西中医药大学第一附属医院，广西 南宁 530021；2.广西中医药大学，广西 南宁 530000）
关键词:
参附注射液; 心肺复苏; 心功能不全
Keywords:
Shenfu Injection;  cardiopulmonary resuscitation;  cardiac insufficiency
文献标志码:
A
摘要:
目的：探讨早期联合参附注射液对心肺复苏患者心功能不全的临床疗效观察。方法：选取 2015 年 1 月至 2017 年1 月在广西中医药大学第一附属医院急诊科和 ICU 住院的心脏骤停心肺复苏术后自主循环恢复的患者 90 例，采用回顾性病例分组，共分为三组，对照组予常规抢救药物干预，治疗 A、B 两组在此基础上加用参附注射液干预，治疗 A 组于心肺复苏早期基础生命支持阶段干预，治疗 B 组于心肺复苏中高级生命支持阶段干预。比较三组治疗前及治疗后 24H、48H 的 Lee 氏心衰积分、NT-proBNP、血清超敏 C 反应蛋白及生命征指标情况。结果：三组治疗后，Lee 氏心衰积分、NT-proBNP、血清超敏 C 反应蛋白较前均降低。与对照组相比，治疗 A、B 组经 SFI 干预后 NT-proBNP、血清超敏 C 反应蛋白水平较对照组明显下降，P＜0.0001，且 A、B 组比较，A 组优于 B 组，P＜0.05；经治疗 24H、48H 后，治疗 A、B 组均优于治疗组，且 A、B 两组平均动脉压、呼吸频率、血氧饱和度及心率各值比较，A 组优于 B 组，P＜0.05。结论：在心肺复苏后心功能不全患者治疗中，于心肺复苏早期基础生命支持阶段联合参附注射液干预可一定程度上缓解心衰症状，降低 NT-proBNP、血清超敏 C 反应蛋白水平，维持生命征平稳，这可能与参附注射液可抑制机体炎症反应、减轻复苏后心肌损伤、调节 RASS 系统相关，但具体作用机制有待深入探析。
Abstract:
Objective: To investigate the clinical effect of early combined Shenfu Injection on cardiac insufficiency in patients withcardiopulmonary resuscitation. Methods: Ninety patients with cardiac arrest and cardiopulmonary resuscitation who recoveredspontaneous circulation after cardiopulmonary resuscitation were selected from January 2015 to January 2017 in the emergencydepartment and ICU of the First Affiliated Hospital of Guangxi University of Chinese Medicine. The patients were divided into threegroups by retrospective case grouping. The control group was given routine rescue drug intervention. Treatment group A and group B onthis basis with Shenfu Injection intervention. Treatment group A in the early basic life support stage of cardiopulmonary resuscitationintervention. Group B was treated with advanced life support intervention in cardiopulmonary resuscitation. Lee’s heart failure score,NT-proBNP, serum hypersensitive C-reactive protein and vital signs were compared before and after treatment for 24H and 48H. Results:After treatment, Lee’s heart failure score, NT-proBNP and serum hypersensitive C-reactive protein were all lower than before. Comparedwith the control group, Lee’s heart failure score, NT-proBNP and serum hypersensitive C-reactive protein in group A and B decreasedsignificantly (P＜0.05); after 24H and 48H treatment, the mean arterial pressure, respiratory rate, oxygen saturation and heart rate ingroup A and B were higher than those in group B before treatment, and the average arterial pressure in group A and B was significantlyhigher than that in group B. The blood pressure, respiratory rate, oxygen saturation and heart rate of group A were significantlyimproved, and group A was better than group B, (P＜0.0001). Conclusion: In the treatment of patients with cardiac insufficiency aftercardiopulmonary resuscitation, the intervention of Shenfu Injection in the early basic life support stage of cardiopulmonary resuscitationcan alleviate the symptoms of heart failure to a certain extent, reduce the levels of NT-proBNP and serum hypersensitive C-reactiveprotein, and maintain the stability of vital signs. This may be related to Shenfu Injection which can inhibit the body’s inflammatoryreaction and reduce it. Myocardial injury and regulation of RASS system after mild resuscitation are related, but the specific mechanismneeds to be further explored

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备注/Memo

备注/Memo:
【收稿日期】2019-05-14【基金项目】广西壮族自治区卫生和计划生育委员会自筹经费科研课题（Z2016667）。【作者简介】邓海霞（1977－），女，广西中医药大学第一附属医院副主任医师，硕士研究生导师，研究方向为中西医结合救治急诊危重症。
更新日期/Last Update: 2020-01-22