[1]梁丽婷,郑 杨.利妥昔单抗治疗滤泡性淋巴瘤的研究进展[J].大众科技,2019,21(05):85-87.
 Research Progress in the Treatment of Follicular Lymphoma with Rituximab[J].Popular Science & Technology,2019,21(05):85-87.
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利妥昔单抗治疗滤泡性淋巴瘤的研究进展()
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《大众科技》[ISSN:1008-1151/CN:45-1235/N]

卷:
21
期数:
2019年05
页码:
85-87
栏目:
医药与卫生
出版日期:
2019-05-20

文章信息/Info

Title:
Research Progress in the Treatment of Follicular Lymphoma with Rituximab
作者:
梁丽婷 郑 杨
(广西中医药大学,广西 南宁 530022)
关键词:
利妥昔单抗滤泡性淋巴瘤研究进展
Keywords:
Rituximab follicular lymphoma research progress
文献标志码:
A
摘要:
目的:回顾近年利妥昔单抗联合化学药物治疗滤泡性淋巴瘤的药理和临床进展。方法:收集近年来国内外的相关文献并进行整理,归纳。结果:利妥昔通过拮抗 CD20 的靶点起到诱导维持治疗非霍奇金细胞瘤作用,同时在治疗初治型、复发型、难治型或其他罕见滤泡性淋巴细胞瘤的过程中,激活补体,增强细胞毒性反应。利妥昔不仅可以单抗用于诱导维持,也可以利妥昔为一线基础药物,联合化疗治疗,延长病人的无进展期、总生存期,提高总缓解率。在临床上疗效肯定,副作用小。
Abstract:
Purpose To review the pharmacological and clinical advances of rituximab combined with chemotherapy in the treatmentof follicular lymphoma in recent years. Methods The relevant literatures at home and abroad were collected and summarized. Results:Rituximab can induce and maintain the treatment of non-Hodgkin’s cell tumors by antagonizing the target of CD20. At the same time, in thetreatment of primary, recurrent, refractory or other rare follicular lymphoma, it can activate complements and enhance the cytotoxicresponse. Rituximab can be used not only for induction and maintenance, but also as a first-line basic drug, combined with chemotherapy,and prolonged the progression-free period and total survival period of the patient, improve the overall remission rate. In clinic, the curativeeffect is affirmative and the side effect is small.

参考文献/References:

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备注/Memo

备注/Memo:
【收稿日期】2019-03-11【作者简介】梁丽婷(1997-),女,广西中医药大学学生,研究方向为临床医学。
更新日期/Last Update: 2020-01-20