[1]唐岚莹,彭均华.火麻仁提取液对 D-GAL 致衰老大鼠认知功能的影响[J].大众科技,2019,21(04):65-67.
　Effects of Extract of Fructus Cannabis on Cognitive Function of Aging RatsInduced by D-GAL[J].Popular Science & Technology,2019,21(04):65-67.
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火麻仁提取液对 D-GAL 致衰老大鼠认知功能的影响()
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《大众科技》[ISSN:1008-1151/CN:45-1235/N]

卷:
21
期数:
2019年04
页码:
65-67
栏目:
医药与卫生
出版日期:
2019-04-20

文章信息/Info

Title:
Effects of Extract of Fructus Cannabis on Cognitive Function of Aging RatsInduced by D-GAL
作者:
唐岚莹;  彭均华
（广西医科大学，广西 南宁 530021）
关键词:
火麻仁提取液; 认知; 记忆
Keywords:
extract of fructus cannabis;  cognition;  memory
文献标志码:
A
摘要:
目的：探究火麻提取物（EFC）对 D-半乳糖（D-gal）诱导的衰老大鼠认知的影响。方法：随机选取 3 月龄的雄性大鼠 48 只，分为 6 组，每组 8 只：正常对照组（control）、D-gal 模型组、EFC（200mg/kg）预防组、EFC（400mg/kg）预防组、D-gal+ EFC（200mg/kg）组、D-gal+ EFC（400mg/kg）组，对各组大鼠进行 Morris 水迷宫的测试。 结果：D-gal 模型组大鼠搜索平台潜伏期增加，寻找隐藏平台的路径更曲折。而 EFC（400mg/kg）预防组和治疗组大鼠潜伏期明显缩短，寻找平台的路径则比较简单。这些结果表明，EFC 可以有效地预防由 D-gal 引起的大鼠空间记忆障碍。结论：火麻仁提取液在一定程度上可以改善 D-gal 致衰老大鼠的认知功能。
Abstract:
Objectives: To investigate the effect of extract of fructus cannabis (EFC) on cognitive function of aging rats induced byD-galactose. Methods: Forty-eight three-month-old male rats were randomly selected and divided into six groups, 8 in each group: normalcontrol group (control), D-gal model group, EFC (200 mg/kg) prevention group, EFC (400 mg/kg) prevention group, D-gal + EFC (200mg/kg) group and D-gal + EFC (400 mg/kg) group. Morris water maze test was conducted in each group. Results: In the D-gal model group,the latency of the search platform increased, and the path to find the hidden platform was more tortuous. However, the latency of rats inEFC (400 mg/kg) prevention group and treatment group was significantly shortened, and the path to find the platform was relatively simple.These results suggest that EFC can effectively prevent D-gal-induced spatial memory impairment in rats. Conclusion: EFC can improve thecognitive function of aging rats induced by D-gal to a certain extent.

参考文献/References:

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备注/Memo

备注/Memo:
【收稿日期】2019-02-12【基金项目】国家自然科学基金（31160209，81860205）。【作者简介】唐岚莹，女，供职于广西医科大学病理生理学教研室，硕士研究生，研究方向为衰老分子遗传学。【通信作者】彭均华，广西医科大学病理生理学教研室副教授，博士，研究方向为衰老分子遗传学。
更新日期/Last Update: 2020-01-17