[1]李柏霖,陈 丹.化合物 2,2-二甲基环戊酮合成工艺研究[J].大众科技,2019,21(04):42-43.
　Study on the Synthesis of Compound 2,2-Dimethylcyclopentanone[J].Popular Science & Technology,2019,21(04):42-43.
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化合物 2,2-二甲基环戊酮合成工艺研究()
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《大众科技》[ISSN:1008-1151/CN:45-1235/N]

卷:
21
期数:
2019年04
页码:
42-43
栏目:
轻工与化工
出版日期:
2019-04-20

文章信息/Info

Title:
Study on the Synthesis of Compound 2,2-Dimethylcyclopentanone
作者:
李柏霖;  陈 丹
（广西梧州制药集团股份有限公司，广西 梧州 543100）
关键词:
硫酸二甲酯; 甲基化; 2; 2-二甲基环戊酮
Keywords:
dimethyl sulfate;  methylation;  2; 2-dimethylcyclopentanone
文献标志码:
A
摘要:
以己二酸二甲酯为原料，在甲醇钠作用下关环，然后经过硫酸二甲酯甲基化作用，再经过脱脂反应得到中间体2-甲基环戊酮，最后在硫酸二甲酯甲基化作用下得到 2,2-二甲基环戊酮。在 2,2-二甲基环戊酮合成过程中考察了溶剂种类、反应温度、甲基化试剂种类及用量对甲基化作用的影响，得到以甲苯为溶剂、反应温度为 35℃、硫酸二甲酯为甲基化试剂、2-甲基环戊酮与硫酸二甲酯比例为 1∶1 的最优甲基化工艺条件。
Abstract:
As raw material，dimethyl adipate was closed loop under sodium methylate, then methylation was happened by dimethylsulfate, following the intermediate 2-methylcyclopentanone was obtain after degreasing reaction. Finally, 2,2-dimethylcyclopentanone wasobtained by methylation of dimethyl sulfate. In the synthesis of 2,2-dimethylc-yclopentanone, the effects of solvent type, reactiontemperature, type and dosage of methylation reagent on methylation were investigated. The optimum methylation conditions were obtainedwith toluene as solvent, reaction temperature 35°C, dimethyl sulfate as methylation reagent, and the ratio of 2-methylcyclopentanone todimethyl sulfate was 1∶1.

参考文献/References:

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备注/Memo

备注/Memo:
【收稿日期】2019-02-11【作者简介】李柏霖（1989－），广西梧州人，广西梧州制药集团股份有限公司化学药合成研究员，从事化学药物合成工艺研究。
更新日期/Last Update: 2020-01-17