[1]林承曦 梁秀琳 翁川晴 毛 庆 徐 兢.FFR 对稳定性心绞痛非前降支临界病变介入 治疗的研究[J].大众科技,2018,20(11):32-34.
　FFR in Interventional Treatment of Non-anterior Descending Branch Borderline Lesions in Stable Angina Pectors[J].Popular Science & Technology,2018,20(11):32-34.
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FFR 对稳定性心绞痛非前降支临界病变介入 治疗的研究()
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《大众科技》[ISSN:1008-1151/CN:45-1235/N]

卷:
20
期数:
2018年11期
页码:
32-34
栏目:
医药与卫生
出版日期:
2018-11-20

文章信息/Info

Title:
FFR in Interventional Treatment of Non-anterior Descending Branch Borderline Lesions in Stable Angina Pectors
作者:
林承曦1 梁秀琳2 翁川晴1 毛 庆2 徐 兢1
（1.南京医科大学附属脑科医院，江苏 南京 210029； 2.广西医科大学第二附属医院，广西 南宁 530007）
关键词:
稳定型心绞痛; 冠脉临界病变; 血流储备分数
Keywords:
stable angina pectoris;  borderline coronary lesions;  fractional flow reserve
文献标志码:
A
摘要:
目的：探讨血流储备分数（fractional flow reserve，FFR）在非前降支临界病变介入治疗中的指导意义。方法：回顾2011 年9 月至2014 年9 月在南京脑科医院心内科住院的稳定型心绞痛的患者，收集这些患者中行冠脉造影显示为单支冠脉临界病变并且FFR 值＞0.8 的患者83 例共85 处血管病变，将83 例患者分为非前降支组（包括右冠及回旋支）32 例34 处病变和前降支组51 例共51 处病变，分析其随访期间（48 个月）的主要不良心血管事件（Major Adverse Cardiovascular Events，MACE），包括心绞痛发作、室性心律失常、靶血管血运重建、非致死性心肌梗死和心源性死亡。结果：在FFR 值＞0.8 的稳定型心绞痛的患者中，非前降支组和前降支组的患者在临床基线资料如年龄、吸烟史、高脂血症病史、高血压病史等方面均无统计学差异，但非前降支组男性比例明显高于前降支组；通过定量冠状动脉造影测量，发现非前降支组患者的冠脉狭窄程度明显高于前降支组（P＝0.000），但前降支组FFR 值却明显低于非前降支组（P＝0.000）。经过48 个月的随访，非前降支组的MACE的发生率明显低于前降支组（P＝0.006）。结论：在稳定型心绞痛的患者中，非前降支临界病变的患者较前降支临界病变的患者拥有更好的长期预后。
Abstract:
Aim: To explore the clinical significance of fractional flow reserve (FFR) in interventional therapy of non-anterior descending branch borderline lesions. Method: 83 patients with stable angina pectoris who were admitted to the department of cardiology of Nanjing Brain Hospital from September 2011 to September 2014 were selected. The patients were performed coronary angiography, which showed there was single coronary borderline lesion. Moreover, FFR value was greater than 0.8. The patients were divided into the non-anterior descending branch group including 32 patients and 34 lesions, and the anterior descending branch group including 51 patients and 51 lesions. Major Adverse Cardiovascular Events (MACE) during the follow-up period (48 months) were analyzed, including angina attack, ventricular arrhythmia, target vessel revascularization, non-fatal myocardial infarction and cardiac death. Results: In the patients with stable angina pectors with FFR＞0.8, there were no significant differences between the two groups in clinical baseline data, such as age, smoking, hyperlipidemia, hypertension, etc. However, the proportion of male was significantly higher in the non-anterior descending group than in the anterior descending branch group. The degree of coronary artery stenosis was significantly higher in the non-anterior descending branch group than in the anterior descending branch group (P＝0.000). However, the FFR value was significantly lower in the anterior descending branch group than the non-anterior descending branch group (P＝0.000). After 48 months of follou-up, the incidence of MACE was significantly lower in the non-anterior descending branch group (P＝0.006). Conclusion: Patients with stable angina pectoris who have borderline lesions in non-anterior descending branch may have better long-term prognosis.

备注/Memo

备注/Memo:
【收稿日期】2018-09-07 【基金项目】广西自然科学基金面上项目（2017GXNSFAA198214）。 【作者简介】林晨曦，男，南京医科大学附属脑科医院心内科主治医师，从事干细胞联合基因治疗冠心病的基础及临床研究。【通信作者】毛庆，广西医科大学第二附属医院心内科副主任医师，博士。
更新日期/Last Update: 2018-12-19