[1]刘冠萍 吕林艳 罗 艳 张木兰 韦日伟.注射用血栓通（冻干）与盐酸克林霉素注射液 配伍的毒性和含量研究[J].大众科技,2018,20(11):26-28.
　Toxicity and Contents of Components in the Compatibility of Lyophilized Xueshuantong for Injection and Clindamycin Hydrochloride Injection[J].Popular Science & Technology,2018,20(11):26-28.
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注射用血栓通（冻干）与盐酸克林霉素注射液 配伍的毒性和含量研究()
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《大众科技》[ISSN:1008-1151/CN:45-1235/N]

卷:
20
期数:
2018年11期
页码:
26-28
栏目:
医药与卫生
出版日期:
2018-11-20

文章信息/Info

Title:
Toxicity and Contents of Components in the Compatibility of Lyophilized Xueshuantong for Injection and Clindamycin Hydrochloride Injection
作者:
刘冠萍 吕林艳 罗 艳 张木兰 韦日伟
（广西梧州制药（集团）股份有限公司，广西 梧州 543002）
关键词:
注射用血栓通（冻干）; 盐酸克林霉素注射液; 配伍; 毒性; 含量
Keywords:
lyophilized Xueshuantong for injection;  clindamycin hydrochloride injection;  compatibility;  toxicity;  content
文献标志码:
A
摘要:
目的：研究注射用血栓通（冻干）与盐酸克林霉素注射液配伍的毒性和含量变化情况，为临床合理用药提供依据。方法：通过小鼠急性毒性试验，了解两者配伍后毒性变化；采用高效液相方法检测两者配伍后含量变化情况。结果：注射用血栓通（冻干）与盐酸克林霉素注射液配伍前后主要成分含量无明显变化，但两者配伍后毒性增加。结论：注射用血栓通（冻干）与盐酸克林霉素注射液不宜在临床上配伍使用。
Abstract:
Objective: To research on the changes of the toxicity and the contents of components after compatibility of lyophilized Xueshuantong for injection and clindamycin hydrochloride injection, and provide a basis for rational use of drugs. Methods: The changes of the compatibility toxicity were studied through the acute toxicity test in mouse, and the contents of components in lyophilized Xueshuantong and clindamycin hydrochloride injection were examined by HPLC method. Results: The contents of main components did not change significantly after compatibility of the two medicines, but the toxicity increased. Conclusion: The compatibility of lyophilized Xueshuantong and clindamycin hydrochloride injection should be avoided in clinic.

参考文献/References:

【参考文献】 [1] 陈旭,吴旭霞,赵喜荣.注射用血栓通联合抗生素引起五例不良反应分析[J].实用药物与临床,2012,15(2):102-103. [2] 刘昌孝,孙瑞元.药物评价实验设计与统计学基础[M].北京:军事医科出版社,1993. [3] 朱天新,袁彩君,李晓红.科博肽与三种药物配伍使用的实验研究[J].中国现代应用药学,2007,24(5):415-418. [4] 阎爱荣,彭芳辰.10 种中药注射液的不良反应及相关因素分析[J].中国医院药学杂志,2008,28(9):765-766. [5] 麦记严.精细药液过滤器预防血栓通注射液不良反应的效果研究[J].实用临床医药杂志,2011,15(4):40-42. [6] 李秋,廖华,王珊.转化糖电解质与两种药物配伍致微粒增加[J].医药导报,2012,31(2):255-256.

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备注/Memo

备注/Memo:
【收稿日期】2018-09-26 【作者简介】刘冠萍（1959－），男，广西梧州制药（集团）股份有限公司高级工程师，研究方向为中药药品研发。
更新日期/Last Update: 2018-12-19