[1]覃 辉 张永全 谭文澜 陆 晖.复脑灵方对血管性痴呆大鼠模型的 学习记忆能力的影响[J].大众科技,2018,20(10):54-55，64.
　Effects of Funaolingfang on Learning and Memory Ability in Vascular Dementia Rat[J].Popular Science & Technology,2018,20(10):54-55，64.
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复脑灵方对血管性痴呆大鼠模型的 学习记忆能力的影响()
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《大众科技》[ISSN:1008-1151/CN:45-1235/N]

卷:
20
期数:
2018年10期
页码:
54-55，64
栏目:
医药与卫生
出版日期:
2018-10-20

文章信息/Info

Title:
Effects of Funaolingfang on Learning and Memory Ability in Vascular Dementia Rat
作者:
覃 辉1; 2 张永全2 谭文澜2 陆 晖2
（1.天津中医药大学，天津 300193；2.广西中医药大学附属瑞康医院，广西 南宁 530011）
关键词:
复脑灵; 血管性痴呆; 中药
Keywords:
Funaolingfang;  vascular dementia;  traditional Chinese medicine
文献标志码:
A
摘要:
目的：观察复脑灵方对血管性痴呆（VD）模型大鼠学习记忆能力的影响，为中药治疗VD 的临床应用提供部分实验依据。方法：选用雄性SD 大鼠，采用双侧颈总动脉永久结扎（2-VO）方法制备VD 动物模型，并随机分为假手术组、模型组、复脑灵方组。采用Morris 水迷宫方法检测各组大鼠记忆功能。结果：逃避潜伏期结果显示：与假手术组相比，模型组逃避潜伏期明显延长，差异具有统计学意义（P＜0.05）；与模型组相比，复脑灵组逃避潜伏期明显缩短，差异具有统计学意义（P＜0.05）；空间探索结果显示，与模型组比较，复脑灵方组大鼠穿越平台次数有增加趋势，但组间无统计学意义( P＞0.05)。结论：复脑灵方能改善血管性痴呆模型大鼠学习记忆能力。
Abstract:
Objective: To observe the effect of Funaolingfang on the learning and memory ability of rats with vascular dementia (VD), and provide some experimental evidence for the clinical application of traditional Chinese medicine in the treatment of VD. Methods: Male SD rats were used to prepare VD animal models by bilateral common carotid artery ligation (2-VO). The rats were randomly divided into sham operation group, model group and Funaolingfang group. The memory function of each group of rats was detected by Morris water maze method.Results: Compare with the sham operation group, the escape latency of the model group was significantly longer (P＜0.05); compared with the model group, the escape latency of Funaolingfang group was significantly shortened (P＜0.05). For space exploration, compared with that in the model group, the number of passing through the platform of Funaolingfang group tended to increase, but there was no statistical difference between the two groups (P＞0.05).Conclusion: Funaolingfang can improve the learning and memory ability of rats with vascular dementia.

参考文献/References:

【参考文献】 [1] Carson D D, Bagchi I, Dey S K, et al. Embryo implantation [J]. Developmental Biology, 2000, 223(2): 217-237. [2] 徐叔云.药理实验方法学[M].北京:人民卫生出版社,2002. [3] 张永全,陆晖,刘泰.复脑灵口服液对痰瘀型血管性痴呆智能及超氧化物歧化酶的影响[J].广西中医药,2001,24(2):6-7. [4] 王恰如,陆晖,谢金鲜,等.复脑灵口服液治疗血管性痴呆的临床研究[J].中西医结合心脑血管病杂志,2003,1(8):446- 447. [5] 陆晖,刘泰,张永全,等.复脑灵口服液治疗血管性痴呆疗效观察[J].广西医科大学学报,2001,18(4):503-505. [6] 陆晖.复脑灵口服液治疗脑梗塞高粘血症41 例-附20 例对照[J].辽宁中医杂志, 2000,27(10):450-451. [7] 赵艳青,滕晶.基于中医传承辅助平台系统的血管性痴呆组方用药规律分析[J].中国中医基础医学杂志,2015(6): 739-741.

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备注/Memo

备注/Memo:
【收稿日期】2018-08-03 【作者简介】覃辉（1980－），男（壮族），广西忻城人，天津中医药大学在读博士研究生，广西中医药大学附属瑞康医院主治医师，研究方向为脑血管疾病及痴呆。
更新日期/Last Update: 2018-11-20