[1]罗纳新 秦琴琴 龚文姣 李 海.补气活血法干预卵巢巧克力囊肿术后复发的 临床疗效[J].大众科技,2018,20(10):38-41.
　Clinical Effect of Buqihuoxuefa on Postoperative Recurrence of Ovarian Endometrial Cyst[J].Popular Science & Technology,2018,20(10):38-41.
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补气活血法干预卵巢巧克力囊肿术后复发的 临床疗效()
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《大众科技》[ISSN:1008-1151/CN:45-1235/N]

卷:
20
期数:
2018年10期
页码:
38-41
栏目:
医药与卫生
出版日期:
2018-10-20

文章信息/Info

Title:
Clinical Effect of Buqihuoxuefa on Postoperative Recurrence of Ovarian Endometrial Cyst
作者:
罗纳新1 秦琴琴1 龚文姣1 李 海2
（1.广西中医药大学第一附属医院，广西 南宁 530023； 2.广西中医药大学公共卫生与管理学院，广西 南宁 530200）
关键词:
补气活血法; GnRHa; 巧克力囊肿; 术后复发; 临床疗效
Keywords:
Buqihuoxuefa;  GnRHa;  ovarian endometrial cyst;  postoperative recurrence;  clinical effect
文献标志码:
A
摘要:
目的：观察补气活血法联合注射醋酸亮丙瑞林微球（GnRHa）干预卵巢巧克力囊肿（OEC）患者术后复发的临床疗效。方法：将60 例OEC 术后患者，随机分为中药组（抑异方）、西药组（GnRHa）、中西药结合组3 组，每组20 例。所有患者均从术后第7 天开始治疗，以1 个月为1 个疗程，共治疗3 个疗程，停药后6 个月随访。观察3 组患者治疗前、治疗后和停药后6 个月的中医证候评分、有效率、妇科B 超变化、CA125 水平及复发情况。结果：治疗后及停药后6 个月三组患者的中医证候评分差异均有统计学意义（P＜0.05）。三组患者组内治疗前与治疗后、治疗前与停药后6 个月的中医证候评分差异有统计学意义（P＜0.05）。中药组、西药组和中西药结合组的总有效率分别为85%、80%和95%，差异无统计学意义（P＞0.05），西药组与中西药结合组差异有统计学意义（P＜0.05）。三组患者间治疗前与治疗后、治疗前与停药后6 个月的CA125 水平均有差异（P＜0.05）。中药组、西药组、中西药结合组的复发率分别为15%、10%、0%，差异有统计学意义（P＜0.05）。结论：补气活血法可显著改善患者下腹痛和痛经、性交痛等症状，与GnRHa 联合使用可显著提高临床疗效、降低GnRHa 的临床副作用，对降低CA125 值、降低术后复发率也有一定作用。
Abstract:
Objective: To observe the clinical effect of Buqihuoxuefa combined with GnRHa on postoperative recurrence of ovarian endometrial cyst. Methods: 60 cases of Ovarian endometrial cyst patients which diagnosed by inclusion criteria were randomly divided into three groups, including Chinese medicine group (CMG), western medicine group (WMG), and traditional Chinese medicine combined with western medicine group (CWG). Each group was treated by different intervention. Three groups of patients were treated for three months after the surgery 1 week, and were follow-up in 6 months after drug withdrawal. The TCM symptom score, efficiency, gynecological B-ultrasound changes, CA125 level, and recurrence status were observed before treatment, after treatment and 6 months after drug withdrawal. Results: TCM symptom score of three groups of patients in three months after treatment and 6 months after drug withdrawal were both significant with statistical difference (P＜0.05).TCM symptom score in each group before treatment and after treatment, before treatment and after drug withdrawal were significant with statistical difference (P＜0.05). The total efficiency of CMG WMG and CWG were 85%, 80% and 95%, respectively, with has no statistical significant difference (P＞0.05). And the total efficiency of WMG and CWG has statistical significant difference (P＜0.05). The CA125 level between the groups of before treatment and 3 months after treatment, and between the groups of before treatment and 6 months after drug withdrawal were statistical significant(P＜0.05).The recurrence rate of ovarian endometrial cyst of the three groups were 15%, 10%, and 0%, respectively, and have statistical significant (P＜0.05). Conclusions: The current study showed that Buqihuoxuefa could significantly reduce the symptom of abdominal pain, dysmenorrhea and dyspareunia symptoms. Buqihuoxuefa combined with GnRHa, which were not only improve clinical effect, but also reduced the side effect of GnRHa. Buqihuoxuefa combined with GnRHa could also play an important role for reduce the CA125 level, postoperative recurrence rate of ovarian endometrial cyst significantly, which were worth spreading in clinical application.

参考文献/References:

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备注/Memo

备注/Memo:
【收稿日期】2018-08-07 【基金项目】广西中医药民族医药自筹经费科研课题（GZZC15-85）。 【作者简介】罗纳新（1969－），女，广西陆川人，广西中医药大学第一附属医院副主任医师，研究方向为中医药治疗不孕不育。 【通信作者】李海（1979－），男，广西桂平人，广西中医药大学公共卫生与管理学院流行病学教研室副主任医师，博士，研究方向为流行病与卫生统计学。
更新日期/Last Update: 2018-11-20