[1]高玉 刘俊佳 黄仁发.磷脂酶A2 受体及其抗体诊断特发性膜性肾病的研究进展[J].大众科技,2018,20(06):91-93.
　Research progress of phospholipase A2 receptor and its antibody in the diagnosis ofidiopathic membranous nephropathy[J].Popular Science & Technology,2018,20(06):91-93.
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磷脂酶A2 受体及其抗体诊断特发性膜性肾病的研究进展()
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《大众科技》[ISSN:1008-1151/CN:45-1235/N]

卷:
20
期数:
2018年06期
页码:
91-93
栏目:
医药与卫生
出版日期:
2018-06-20

文章信息/Info

Title:
Research progress of phospholipase A2 receptor and its antibody in the diagnosis ofidiopathic membranous nephropathy
作者:
高玉1 刘俊佳1 黄仁发2
关键词:
磷脂酶A2 受体; 特发性膜性肾病; 研究进展
Keywords:
Phospholipase A2 receptor;  idiopathic membranous nephropathy;  research progress
文献标志码:
A
摘要:
膜性肾病（Membranous nephropathy，MN）是造成成人肾病综合征的比较重要的原因之一，目前膜性肾病的诊断主要依靠肾脏活检病理学诊断。而特发性膜性肾病（Idiopathic membranous nephropathy，IMN）是MN中病因不明确的一种类型，其发病机制并不十分清楚，且很难与继发性膜性肾病（Secondary membranous nephropathy，SMN）相鉴别，磷脂酶A2受体（anti-phospholipase A2 receptor，PLA2R）及其抗体的发现对IMN的诊断、鉴别诊断及其预后有着重要的意义。文章通过对PLA2R 及其抗体在诊断特发性膜性肾病中作用的研究进展进行论述。
Abstract:
Membranous nephropathy (MN) is one of the main causes of nephrotic syndrome in adults. Currently, the diagnosis ofmembranous nephropathy mainly depends on pathological diagnosis of renal biopsy. Idiopathic membranous nephropathy (IMN) is atype of ambiguity in MN. Its pathogenesis is not very clear and it is difficult to differentiate from secondary membranous nephropathy(SMN).The discovery of phospholipase A2 receptor (PLA2R) and its antibodies has important implications for the diagnosis, differentialdiagnosis and prognosis of IMN. This article discusses the research progress of the role of PLA2R and its antibodies in the diagnosis ofidiopathic membranous nephropathy.

参考文献/References:

【参考文献】[1] 彭梅,李贵森.膜性肾病发病机制研究进展[J].内科理论与实践,2017,5(4):405-408.[2] Ronco P,Debiec H.Pathophysiological advances in membranousnephropathy:time for a shift in patient’s care[J].Lancet,2015,385(9981):1983.[3] 黄丽琪.特发性膜性肾病患者临床病理特点及预后研究[D].南昌:南昌大学,2014:159-164.[4] 洪虹,李秀珍,徐文莲.膜性肾病临床流行病学分析[J].中国全科医学,2017,20(S2):1035-1037.[5] 洪艳.特发性膜性肾病发病机制研究进展[J].实用医学杂志,2012,28(8):1379-1380.[6] 席小红,李国芬,李新.血清PLA2R抗体与膜性肾病患者病情的相关性[J].中国现代医学杂志,2016,26(4):67-70.[7] Hofstra J M,Jr B L,Beck D M,et al.Anti-phospholipase A?receptor antibodies correlate with clinical status inidiopathic membranous nephropathy.[J].Clinical Journal ofthe American Society of Nephrology,2011,6(6):1286-1291.[8] Radice A,Trezzi B,Maggiore U,et al.Clinical usefulness ofautoantibodies to M-type phospholipase A2 receptor(PLA2R) for monitoring disease activity in idiopathicmembranous nephropathy (IMN)[J].Autoimmunity Reviews,2015,15(2):146.[9] Liu Y H,Chen C H,Chen S Y,et al.Association ofphospholipase A2 receptor 1,polymorphisms with idiopathicmembranous nephropathy in Chinese patients in Taiwan[J].Journal of Biomedical Science,2010,17(1):1-8.[10] Gunnarsson I,Schlumberger W,R?nnelid J.Antibodies to Mtypephospholipase A2 receptor (PLA2R) and membranouslupus nephritis[J].American Journal of Kidney Diseases,2012,59(4):585-586.[11] Xipell M,Rodas L M,Villarreal J S,et al.The utility ofphospholipase A2 receptor autoantibody in membranousnephropathy after kidney transplantation[J].Ckj ClinicalKidney Journal,2017(4):759-763.[12] Seras M,Segundo D S,Kislikova M,et al.Anti-PLA2RMonitoring in Relapsing Membranous Nephropathy afterKidney Transplantation[J].American Journal of KidneyDiseases,2013,60(3):465-466.[13] 王晓东,米娜娃尔,玉努斯,等.新疆地区血清抗磷脂酶A2受体抗体阳性肾病患者临床资料分析[J].新疆医学,2017,47(11):895-898.[14] 周广宇,张文龙,吴晨,等.血清抗M 型磷脂酶A2 受体抗体与膜性肾病表现及治疗反应的关系[J].中国老年学,2017,37(14):1064-1066.[15] 李隽. M型磷脂酶A2受体抗体在膜性肾病诊断中的应用[D].北京:北京中医药大学,2013.[16] Beck L H,Sethi S,Fervenza F C.M-type Phospholipase A2Receptor (PLA2R) and Thrombospondin Type-1 Domain-Containing 7A (THSD7A) in Membranous Nephropathy[J].Springer Japan,2016,(4)279-283.[17] 朱加明,丁小强.特发性膜性肾病足细胞靶抗原的新认识[J].肾脏病与透析肾移植杂志,2010,19(4):350-353.

备注/Memo

备注/Memo:
【作者简介】高玉（1988－），女，河南泌阳人，广西中医药大学在读研究生，研究方向为急慢性肾衰竭的中西医结合防治；刘俊佳（1990－），男，河南正阳人，广西中医药大学在读研究生，研究方向为中医骨伤科学。【通信作者】黄仁发（1972－），男，广西中医药大学附属瑞康医院肾内科主任医师，研究生导师。
更新日期/Last Update: 2018-07-12