[1]梁飞红.奥沙利铂神经毒性临床护理的研究进展[J].大众科技,2014,16(11):128-130.
 Research progress on clinical nursing of Oxaliplatin induced neurotoxicity[J].Popular Science & Technology,2014,16(11):128-130.
点击复制

奥沙利铂神经毒性临床护理的研究进展()
分享到:

《大众科技》[ISSN:1008-1151/CN:45-1235/N]

卷:
第16卷
期数:
2014年11期
页码:
128-130
栏目:
医药与卫生
出版日期:
2015-01-01

文章信息/Info

Title:
Research progress on clinical nursing of Oxaliplatin induced neurotoxicity
文章编号:
1008-1151(2014)11-0128-03
作者:
梁飞红
广西中医药大学第一附属医院,广西 南宁 530023
关键词:
奥沙利铂神经毒性护理研究进展
Keywords:
Oxaliplatin neurotoxicity nursing research progress
分类号:
R472
文献标志码:
A
摘要:
奥沙利铂是继顺铂和卡铂之后的第三代铂类化疗药,具有抗癌活性高、抗瘤谱广、不良反应轻的特点。其联合氟尿嘧啶、亚叶酸钙已成为结直肠癌术后辅助治疗及进展期治疗的标准方案。神经毒性是奥沙利铂不良反应中最为常见的一种,有文献报道,奥沙利铂的神经毒性反应发生率可85%~95%[1-4],严重影响患者生活质量,甚至部分患者因不能耐受神经毒副反应而停止治疗。如何采取规范的临床护理措施是有效预防和减轻其神经毒性反应的重要课题。
Abstract:
Oxaliplatin is the third generation platinum chemotherapy after cisplatin and carboplatin, with high anticancer activity,antitumor spectrum, less adverse reaction characteristics. Oxaliplatin combined with fluorouracil, leucovorin has become standardtreatment and assist in treatment of advanced colorectal cancer after operation. The adverse reactions of Oxaliplatin neurotoxicity is oneof the most common,are reported in the literature,the occurrence of neurotoxicity of oxaliplatin reaction rate can be as high as85%-95%,seriously affect the quality of life of the patients, even in some patients because of adverse reaction of intolerant of nerve andstop treatment. How to take measures to standardize the clinical nursing is an important subject to effectively prevent and mitigate itsneurotoxic reactions.Key words: Oxaliplatin;

参考文献/References:

[1] André T,Boni C,Mounedji-Boudiaf L,et al. Oxaliplatin,fluorouracil,and leucovorin as adjuvant treatment for coloncancer[J].N Engl J Med,2004,350(23):2343-2351.[2] Misset JL.Oxaliplatin in practice[J].Br J Cancer,1998,77(4):4-7.[3] Lévi FA, Zidani R, Vannetzel JM, et al. Chronomodulatedversus fixed-infusion-rate delivery of ambulatorychemotherapy with oxaliplatin, fluorouracil, and folinic acid(leucovorin) in patients with colorectal cancer metastases: arandomized multi-institutional trial[J].J Natl CancerInst,1994,86(21):1608-1617.[4] Wilson RH,Lehky T,Thomas RR,et al. Acute oxaliplatin- inducedperipheral nerve hyperexcitability[J].J Clin Oncol, 2002,20(7):1767-1774.[5] 李倩.奥沙利铂的神经毒性和防治进展[J].上海交通大学学报,2006,26(4):430-433.[6] 罗展雄,倪秉强.奥沙利铂神经毒性的预防和处理的研究进展[J].当代医学,2009,15(21):83-85.[7] 段小芳.护理干预对减缓奥沙利铂化疗后毒副作用的体会[J].湖南中医杂志,2005,21(3):107-108.[8] Park SB,Lin CS,Krishnan AV,et al.Long-term neuropathyafter oxaliplatin treatment: challenging the dictum ofreversibility[J].Oncologist,2011,16(5):708-716.[9] 陈礼颜.奥沙利铂化疗致病人神经毒性反应的护理[J].全科护理,2010,8(1):18-19.[10] 郑化灵.奥沙利铂化疗致外周神经毒性的护理干预[J].当代护士,2008,(5):68-69.[11] 周礼鲲,胡珊珊,乔磊,等.钙镁合剂预防奥沙利铂所致神经毒性的系统评价和Meta 分析[J].中国肿瘤临床,2012,39(23):1921-1925.[12] 杨武,喻永龙,王新帅,等.钙镁合剂和甲钴胺预防奥沙利铂所致神经毒性疗效比较[J].蚌埠医学院学报,2013,38(1):37-40.[13] Cascinu S1, Catalano V,Cordella L,et al. Neuroprotectiveeffect of reduced glutathione on oxaliplatinbased chemotherapyin advanced colorectal cancer: a randomized,double-blind, placebo-controlled trial[J].J Clin Oncol,2002,20(16):3478,83.[14] 曹顺金.黄芪桂枝五物汤加味防治奥沙利铂所致外周神经毒性疗效观察[J].光明中医,2013,28(1):88- 89.[15] 刘展华,吴玉生,谭开基.川芎嗪预防奥沙利铂致神经毒性反应14 例[J].实用中医药杂志,2003,11(19): 575.[16] 崔德利,王立新.温针灸治疗奥沙利铂神经毒性的临床观察[J].甘肃中医,2011,24(2):45-46.[17] 吴燕,陈梅,余悦.穴位贴敷防治奥沙利铂周围神经毒性的护理研究[J].护理研究,2012,26(8):2054-2055.[18] 王英,郑广.穴位按压及经络拍打结合循证护理缓解奥沙利铂神经毒性的疗效观察[J].中西医结合研究,2013,16(5):1556-1558.[19] 方灿途,孟金成,张华堂.双筋龙汤外用对奥沙利铂导致神经毒性的预防作用[J].中医临床研究,2012,3 (4):36-37.[20] 房敏,梁晓燕,张红弟,等.实施临床护理路径降低奥沙利铂神经毒性[J].护理学杂志,2013,28(11):27-28.

备注/Memo

备注/Memo:
【收稿日期】2014-10-13【基金项目】广西壮族自治区卫生厅计划课题(合同号z2014098)。【作者简介】梁飞红(1973-),女,广西中医药大学第一附属医院肿瘤科主管护师,研究方向为肿瘤临床护理。
更新日期/Last Update: 2016-10-28