[1]郭 灵 莫飞嵘 磨洁琳.经手术切除甲状腺和嗅球的大鼠有可能成为 一种难治性抑郁症的实验动物模型[J].大众科技,2013,15(12):124.
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经手术切除甲状腺和嗅球的大鼠有可能成为 一种难治性抑郁症的实验动物模型
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《大众科技》[ISSN:1008-1151/CN:45-1235/N]

卷:
第15卷
期数:
2013年12期
页码:
124
栏目:
医药与卫生
出版日期:
2013-12-31

文章信息/Info

Title:
Thyroidectomized-olfactory bulbectomized rat may be a potential animal model of treatment-resistant depression with hypothyroidism
文章编号:
1008-1151(2013)12-0124-04
作者:
郭 灵 莫飞嵘 磨洁琳
广西医科大学人体解剖学教研室，广西 南宁 530021
关键词:
甲状腺切除术; 嗅球切除术; 难治性抑郁症; 甲状腺功能低下; 实验动物模型
Keywords:
Thyroidectomy;  olfactory bulbectomy;  treatment-resistant depression;  hypothyroidism;  experimental animal model
分类号:
R749.42
文献标志码:
A
摘要:
目的：探讨建立伴有甲状腺功能低下的难治性抑郁症实验动物模型的可行性。方法：将 30 只雄性 SD大鼠随机 分成 3 组，每组 10 只：模型组、假手术组、正常对照组。模型组大鼠首先接受甲状腺切除术，7 天后再次接受双侧嗅球切除术； 对假手术组大鼠除了不切除甲状腺与双侧嗅球以外，其余操作均与模型组的完全相同；对正常对照组大鼠则不进行任何处理。 在最终手术后的第 2 周，采用旷场试验、强迫游泳试验与 Morris 水迷宫测试各组大鼠的行为变化。结果：与正常对照组或假手 术组大鼠相比较，模型组大鼠长生相对停滞、
Abstract:
Objective: To examine whether surgical paradigm (TX+OBX) of thyroidectomy (TX) and olfactory bulbectomy (OBX) performed on rats potentially becomes an animal model of treatment-resistant depression with hypothyroidism. Methods: Thirty Sprague-Dawley adult male rats were randomly divided into three groups with ten rats in each group: model, sham and intact. Both TX and OBX were subsequently performed on rats in model group. After two weeks of OBX operation, open field test, forced swimming test and Morris water maze were used to measure the behavioral changes shown by rats in the three groups. Results: Rats in model group had a lower body weight with a retardation of body growth, and displayed an anxiety-like or agitated depression-like behavior as well as poor ability of spatial learning and memory. These parameter changes in model group rats were statistically different from those in intact group rats or in sham group rats( P ＜0.01), but no statistical differences of the above parameters existed between intact group rats and sham group rats( P ＞0.05). Conclusion based on the above data, the pattern of TX+OBX rats largely mimics the etiology and the symptoms of treatment-resistant depression with hypothyroidism , and therefore it potentially becomes a possible animal model of agitated subtype in treatment-resistant depression with hypothyroidism, and may be used as a platform for subsequent intervention of combined thyroid hormone and antidepressant drugs and for exploring relative pharmacological mechanisms of antidepressant therapy.

参考文献/References:

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备注/Memo

备注/Memo:
【收稿日期】2013-11-17 【基金项目】广西自然科学基金项目（桂科自 0542069）；广西高校自然科学基金项目（201012MS035）。 【作者简介】郭灵（1960－），男，广西医科大学人体解剖学教研室教授，医学博士，从事发育神经精神内分泌学研究
更新日期/Last Update: 1900-01-01